Prof. Dr. Ivan Đikić

+49 (0) 69 6301-5652

Ivan Đikić is a leading expert in the fields of ubiquitin biology and cancer research. He is a professor at Goethe University Frankfurt and a fellow of Max Planck Society. He maintains the active research lab that enables multidisciplinary teams of scientists to study molecular principles of life and discovering pathological alterations that lead to the development of human diseases such as cancer, neurodegeneration and infection.

For his scientific work, Ivan received numerous awards, including the Ernst Jung Prize for Medicine and the Gottfried Wilhelm Leibniz Prize, the highest scientific honor in Germany. He is an elected member the EMBO, the German Academy Leopoldina and the European Academy, as well as an honorary member of the American Academy of Arts and Sciences. Ivan Đikić is committed to the education of the next generations of scientists globally. His efforts to popularize science in the public were recognized by the highest civilian state honors, The Order of Duke Branimir, bestowed by the President of Croatia.




Dr. Adriana Covarrubias

+49 (0) 69 6301-83815

Adriana was born in La Serena, Chile. She obtained her Agronomic sciences degree at the University of La Serena. Her thesis was focused on the tolerance strategies under abiotic stress in Chenopodium quinoa. Adriana then decided to study a PhD in Cellular and Molecular Biology at the University Austral of Chile, Valdivia (Chile). Her research was dedicated in the Vitamin C homeostasis at the Central Nervous System and first focused on how ascorbic acid regulates the trafficking of SVCT2 transporter and second how the failure in the ascorbic acid homeostasis impaired the glucose uptake modulation in Huntington disease under the supervision of Dr. Maite A. Castro. In November 2017, Adriana joined the group of Ivan Dikic as a Postdoctoral researcher investigating the role of linear ubiquitination in the remodeling heart during myocardial infarct. Also, Adriana is currently  studying novel mechanisms involved specifically in the regulation of ER-phagy.




Dr. Ah Jung Heo

Ah Jung was born in the Republic of Korea. She obtained her bachelor’s degree in 2014 and at Yonsei University, Seoul Korea. Then she obtained her combined MS/Ph.D degree in 2022 at Seoul National University, Seoul Korea. Her thesis was focused on cellular degradative biology in the Arg/N-degron pathway in the context of oxidative stress and hypoxia. In April 2023, she joined the laboratory of Ivan Dikic as a postdoctoral researcher to investigate the biochemical properties of membrane E3 ligases in the context of cancer pathogenesis.




Dr. Alexis Gonzalez

+49 (0) 69 6301-83815

Alexis obtained his PhD degree in faculty of sciences, Austral University, Valdivia, Chile. During his Ph.D. research, he studied the role of the proteasome system and autophagy in the degradation and proteolityc processing of amyloid precursor protein (APP). In November 2017, Alexis joined the group of Ivan Dikic as a Postdoctoral researcher investigating how phosphoribosyl-linked serine ubiquitination affects cellular functions as well as ER-phagy mechanism.




Dr. Anne-Claire Jacomin

+49 (0) 69 6301-83816

Anne-Claire did her PhD in the lab of Marie-Odile Fauvarque (Université Grenoble-Alpes – France). Her work focused on the importance of ubiquitination in immune signaling and autophagy, with a specific interest in deubiquitinating enzymes. In 2014, she joined Ioannis Nezis at the University of Warwick – UK, for a postdoc aiming at deciphering the molecular mechanisms of selective autophagy in Drosophila. Since 2020, she joined the group of Ivan Dikic and the Frankfurt Cancer Institute as a research assistant to work on the molecular mechanisms of tumor pathogenesis and the development of targeted therapies.




Antonia Hofmann

+49 (0) 69 6301-83816

Antonia obtained her Bachelor’s degree in Biology at Goethe University in Frankfurt am Main. After graduating in 2015 she started studying Marine Biology at the University of Rostock and received her Master’s degree. In May 2018, Antonia joined the Dikic group as a Technical Assistant to support the group.




Dr. Audrey Xavier

Audrey studied biochemistry at the university of Tuebingen (BSc) and Free university of Berlin (Msc). After completing her master’s thesis in the lab of Sun Hur (HMS) focusing on antiviral mechanisms of the pattern recognition receptor RIG-I, Audrey joined the lab of Oliver Daumke at MDC Berlin for Ph.D. During her PhD she investigated signaling pathways of the antibacterial GTPase GBP1. In line with her previous work, she joined the Dikic group in June 2021 as a postdoctoral fellow to explore mechanisms of host-viral interactions.




Borna Markušić

Borna was born and grew up in Zagreb, Croatia. He obtained his bachelor’s degree in Biochemistry at the University of the Sciences in Philadelphia in the spring of 2022. There, he investigated MAPK signaling pathway using MD simulations and biophysical methods, with experience in protein purification and interaction analysis. In the autumn of 2022, he joined the Dikic group as a MS/PhD student through the IMPRS program of the Max Planck Institute of Biophysics in Frankfurt. He is currently working on computational and biophysical analyses of ER remodeling.




Dr. Chun Kew

Chun did his PhD in genetics at University of Cologne and Max Planck Institute for Biology of Ageing, Germany. He studied the effects of splicing factors on lifespan and innate immunity, under the supervision of Professor Adam Antebi. Chun joined the Dikic group in 2020. Now he is investigating the communications between extracellular bacteria and intracellular organelles of the host cells.




Dr. Cristian Prieto-Garcia

+49 (0) 69 6301-83815

Cristian obtained his Veterinary medicine degree at the University of Cordoba and the University of Milan. During his degree he did a research internship at King's college London, where he investigated the role of GSK-3 in craniofacial development. After the internship, Cristian studied a Master's degree in Biochemistry, Molecular Biology and Biomedicine at the University Complutense of Madrid. He developed his Master's thesis at the CNIO, his thesis was focused on  the function of KRAS at pre-neoplastic stages of Pancreatic Cancer. Then, Cristian finished his Ph.D. at Wuerzburg University. Under the supervision of Markus Diefenbacher, he revealed that USP28 deubiquitinates and stabilizes ΔNP63 to promote Squamous tumour formation. In June 2020, Cristian joined the group of Ivan Dikic as a Postdoctoral researcher to study the role of ubiquitination in cancer using mouse model.




Dr. Giulio Giuliani

+49 (0) 69 6301-83816

Giulio was born in Rome, Italy. He obtained his master degree in 2017 at the University of Rome Tor Vergata, Italy. His thesis was focused on the role of DNA damage response in osteogenic differentiation of skeletal muscle mesoangioblasts (MABs). Then, in the same university, he performed his PhD in the laboratory of Molecular Genetics directed by Prof. Gianni Cesareni. His research concerned heterogeneity and signaling pathways regulating the fate of skeletal muscle fibro/adipogenic progenitors (FAPs) in a mouse model of Duchenne muscular dystrophy (DMD). After obtaining his PhD in 2021, he did a postdoc on FLT3-driven acute myeloid leukemia (AML) in the laboratory of Dr. Francesca Sacco and in July 2021 he joined the laboratory of Prof. Ivan Đikić as a postdoctoral researcher to study cancer pathogenesis using CRISPR/Cas9 and targeted protein degradation (TPD).




Dr. Henry Bailey

+49 (0) 69 798-42582

Henry studied biochemistry at the University of Bristol and completed his Ph.D. in Prof Wyatt Yue’s Lab at the Structural Genomics Consortium, University of Oxford. The focus of his Ph.D. was to use combinatorial structural approaches to characterise enzymatic complexes associated with rare inborn errors of metabolism. In 2021 he has joined the ‘ProxiDrugs’ consortium applying structure guided drug discovery methods to advance development of proximity inducing therapeutics.




MD, Ines Tomašković

+49 (0) 69 6301-83816

Originally from Zagreb, Croatia, Ines obtained her MD degree with Honours from the Faculty of Medicine, University of Zagreb in July 2015. After the national exam, she was working as a medical doctor at the Institute for Emergency Medicine of Zagreb County. During her studies and professional work, she was awarded several scholarships and completed internships in KABEG Klinikum - Austria, University Hospital Vall d’Hebron - Spain and Texas Medical Center – USA, focusing on both clinical and translational medicine. In June 2018, Ines joined the group of Ivan Dikic as a Ph.D. student, working in the field of translational medicine.




Dr. João Mello-Vieira

Joao Mello-Vieira obtained his Bachelor's (2010) and Master’s (2012) Degrees in Biochemistry from the Faculty of Sciences of the University of Lisbon, Portugal. Afterward, he moved to the Institute of Molecular Medicine João Lobo Antunes, at the Faculty of Medicine of the University of Lisbon, Portugal.  There, he worked on Plasmodium parasites, the causative agents of the tropical disease malaria, under the supervision of Prof. Maria Manuel Mota and Dr. Vanessa Zuzarte-Luís. His Ph.D. focused on the Plasmodium protein Exported Protein 2 (EXP2), and he showed that EXP2 is important for the parasites to infect hepatocytes, during the liver stage of malaria infection. He joined the Dikic group in May 2022, as a post-doctoral researcher. His focus in on targeting the bacterium Acinetobacter baumannii, of the leading causes of hospital infections.
 




Dr. Marina Hoffmann

+49 (0) 69 6301-6298

Marina obtained her Master in bioengineering and bioinformatics at Moscow State University in Russia. She joined Prof.Dr.Petra Beli laboratory for Ph.D. at Institute for Molecular Biology (IMB) in Mainz, Germany. Her thesis was focuseda on the p38-MK2 regulated pathway upon UV light. Since 2018 she joined the group of Ivan Dikic as a Postdoctoral Fellow. She is investigating now mechanisms of selective autophagy activation as well as supports the colleagues with mass-spectrometry expertise and CRISPR/Cas9 screen assays.




Miles Willoughby, Msc

Miles completed his bachelor's degree in biochemistry in 2019 at the Goethe University of Frankfurt, Germany, under the supervision of Prof. Pos, working on heavy metal transport systems in bacteria. Having completed his master's degree with a thesis on ER-organelle membrane contact sites in 2022 in the Stolz lab at the IBC2, Miles started his Ph.D. with Ivan Dikic the same year, studying the action of newly discovered and annotated microproteins in autophagy.




Dr. Mohit Misra

+49 (0) 69 798-42582

Mohit obtained his Master's in Biotechnology in New Delhi and a PG diploma in Bioinformatics ‘A’ level. He worked as a Junior Research Fellow at the International Center for Genetic Engineering and Biotechnology (ICGEB) in the Recombinant Gene Products lab led by Dr. Navin Khanna. He moved to Germany to pursue his PhD in the lab of Prof. Hermann Schindelin where he worked at the apex of the ubiquitylation pathway exploring the structure-function relationship of the ubiquitin-activating enzyme (Uba1) and its interactions with multiple E2 enzymes. In addition, he established the structural basis of the variable potency of adenosyl sulfamate inhibitors towards Uba1 which hold promise for cancer therapy. After a brief postdoc in Würzburg, Mohit moved to Frankfurt to join the Dikic lab to pursue his fascination for novel chemistry of ubiquitylation discovered in Legionella. In May 2020, Mohit started team leader position in conjunction with EUbOPEN IMI/ SGC Frankfurt to target the ubiquitin system with new probes in order to develop therapeutics for human diseases.




Petar Skrobo

Petar was born in Croatia, and he studied Molecular biology at the Faculty of Science, University of Zagreb. During his bachelor’s studies in the summer of 2022, he did an internship in the Dikic group, in which he studied the role of ER-phagy in lipid droplet biology. After his bachelor study in 2023, he started Master's program at the University of Zagreb and continues his research in the group of Ivan Dikic as a Master student.




Thorsten Mosler




Dr. Varun Jayeshkumar Shah

+49 (0) 69 6301-83816

Varun completed his master’s degree in biotechnology from Utkal University, Bhubaneswar, India. He then joined Dr. Maddika Subba Reddy’s laboratory for PhD at Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India. His dissertation was focused on the identification and characterization of CRL7SMU1 , a multi-subunit E3 ligase in the regulation of genomic stability. He has joined the Dikic group in November 2018 where he intends to investigate the roles of E3 ubiquitin ligases and deubiquitinases in lung cancer pathogenesis.




Vigor Matkovic

+49 (0) 69 798-42582

Vigor was born in Rijeka, Croatia. After he finished high school in Opatija, he moved to Zagreb where he obtained his bachelor's degree in Chemistry at the Faculty of Science, University of Zagreb in summer 2016. Two years later he also defended the master thesis in Inorganic and Structural Chemistry at the Department of Chemistry, Faculty of Science, University of Zagreb, obtained the master's degree and two months later, in autumn 2018. he joined the group of Ivan Dikic as a Ph.D. student. During his Ph.D. he is currently working on structural and biochemical identification of the effector proteins from Legionella pneumophila.




Yangxue Fu

+49 (0) 69 6301-83816

Yangxue was born and grew up in China. After high school Yangxue obtained her bachelor degree at the Bochum University, Germany and master degree with a focus on molecular biology at the Heidelberg University, Germany. She worked in MPI for Molecular Physiology in Dortmund, ZMBH and DKFZ in Heidelberg, and has good experience in protein purification and interaction investigation. She did her master thesis in the lab of Roberto Zoncu in the University of California, Berkeley, where She worked on of molecular mechanism for activation of the master growth regulator mTORC1. To expand her interest in molecular signaling, she joined the Dikic group as a Ph.D. student in October 2018. During her Ph.D. she is focusing on the mechanism of receptor and co-factors for ER-phagy.

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Past Members:




Dr. Alexandra Stolz

+49 (0) 69 798-42589

Alexandra Stolz studied Biochemistry in Regensburg, Germany followed by a PhD in yeast genetics and molecular biology in Stuttgart, Germany. After a postdoc (2012-2013) working on ER associated protein degradation (ERAD) – a proteasome dependent pathway, Alexandra joined the groups of Andreas Ernst and Ivan Dikic at IBC2 in Frankfurt, Germany (2013-2016) to work on autophagy. Besides contributing to the characterization of the first autophagy receptor for ER-phagy FAM134B and elaborating the role of the kinase TBK1 in mitophagy, she utilized phage display and protein engineering to develop fluorescent sensors for the central autophagy components LC3/GABARAPs. In January 2017, she joined Genentech in South San Francisco, USA as a visiting scientist where she studied the impact of oncogene-induced secretion during cancer pathogenesis. Since February 2018, Alexandra is heading the phenotypic screening platform at IBC2  and since January 2021 as well the ER quality control group located at the Buchman Institute for Molecular Life Sciences (BMLS) as an indipendent group leader. Alexandra is  associated with EUbOPEN, where her group aims to identify chemical inducers and inhibitors of selective autophagy pathways. 




Dr. Andrea Gubaš

Andrea obtained her Master’s degree in 2013 at the University of Zagreb, Croatia, during which she participated in an Erasmus programme, where she conducted her laboratory experience in the Dikic group. Following her Master’s degree, Andrea was awarded a Cancer Research UK/The Francis Crick Institute-funded studentship in 2014, to conduct a four-year PhD at the Francis Crick Institute and Imperial College London, in London, UK, under the supervision of Dr Sharon Tooze. During her PhD, Andrea focused on studying the regulation of a particular PI3P-effector protein during starvation induced autophagy. Andrea obtained her PhD from Imperial College London in 2018, and driven by the strong passion towards understanding the mechanisms of secretory pathways, Andrea re-joined Dikic group in order to identify novel regulators of various selective autophagy pathways using CRISPR/Cas9 technology. She moved on in 2022.




Dr. Anshu Bhattacharya

Anshu joined the Dikic group as a Ph.D. student in September 2017 and focuses on Quantitative profiling of lysosomal ubiquitylome in altered physiological scenarios. He obtained his Bachelor's degree from Narendrapur Ramkrishna Mission Residential College and his Master's degree from Jadavpur University. After briefly being exposed as a CSIR-Junior Research Fellow at the Indian Institute of Chemical Biology, Kolkata, he moved to Frankfurt, to Dikic group. His thesis was focused on lysophagy and TBC1D15 role in it. After successful defence in 2023, he joined Denali Therapeutics, San Francisco, as a Postdoctoral fellow.




Arora Srinka

Arora has finished her master's degree in Human genomics and Psychology in India. A genetic counselor by profession, she also has experience in genetic and molecular research at CCMB, Hyderabad, specifically Crispr-Cas 9 technology. She is well-versed in various lab techniques. Currently, she is a scholarship student in the group, working on quality control mechanisms of ERphagy receptors.




Daniel Kalina




Dr. Donghyuk Shin




Dr. Hadir Marei

+49 (0) 69 6301-83816

Hadir was born in Cairo, Egypt. She obtained her Bachelor’s degree in Biology with a minor in Chemistry at the American University in Cairo. Following her Bachelor’s, Hadir was awarded a Cancer Research UK studentship to conduct a four-year Ph.D. program at the Cancer Research UK Manchester Institute (CRUKMI) in the Cell Signalling group headed by Angeliki Malliri. During her Ph.D., Hadir focused on dissecting the molecular mechanisms dictating the biological outcomes mediated by the small GTPase Rac1, a key regulator of cytoskeletal rearrangements and cell migration. Stemming from her interest in small GTPases, Hadir joined the Dikic group as a postdoctoral fellow. She investigated the role of regulators of Rab GTPases in modulating autophagy. She also explored the interplay between cytoskeletal regulators and the trafficking machinery under normal and pathological conditions. She finished her work and moved on in 2018.




Dr. Javier Garcia Pardo

Javier obtained both a degree in Biology and a degree in Biochemistry at the Autonomous University of Barcelona (UAB). He completed his PhD in Biochemistry, Molecular Biology and Biomedicine in 2015 in the group of Protein Engineering and Proteomics headed by Prof. FX Avilés at the IBB-UAB. Afterward, he continued his career as a postdoctoral scientist in the group of Prof. Daniel Ruiz-Molina lab at the Catalan Institute of Nanoscience and Nanotechnology (ICN2). He performed different visits to other research groups, such as the laboratory of Prof. Lloyd D. Fricker (AECOM, New York, USA) or the laboratory of Prof. Sir Tom Blundell (University of Cambridge, UK). He joined the Dikic lab in September 2018 and he is currently working with Reticulons, a group of ER-resident proteins involved in membrane curving. He is also investigating the structure and mechanism of human DNA-dependent metalloproteases and working in the discovery of new pharmacological targets for the NF-kB pathway.




Dr. Lina Herhaus

+49 (0) 69 6301-83816

After high school, Lina obtained her first lab work experience in Mexico at the Research center ECOSUR. She then decided to study Applied Biology at the Hochschule Bonn-Rhein-Sieg (Germany) and Molecular Biology at the University of Dundee (UK). She obtained a double degree with Honors. Lina performed her Ph.D. studies at the MRC Protein Phosphorylation and Ubiquitylation Unit in Dundee under Gopal Sapkota. Her dissertation focused on deubiquitylating enzymes regulating the TGF-beta and BMP signaling pathways. Following her Ph.D. studies, Lina received an EMBO fellowship for her postdoctoral research in the lab of Ivan Dikic to work on linear ubiquitylation and autophagy. After her postdoctoral work, she joined the Frankfurt Cancer Institute as a cellular and biochemical analysis platform staff scientist. Lina is now a team leader of the Immune Signaling program, which aims to decipher TBK1-mediated signaling in different pathologies.




Dr. Marcel Hahn

Marcel studied biology at the University of Giessen, Germany, to obtain his Master's degree with a focus on immunology and genetics in 2015. He did his master thesis at the Institute of Immunology, Giessen, where he investigated the Interleukin-1 receptor signaling complex. After a research internship in the lab of Henning Walczak, Cancer Institute University College London, Marcel joined the group of Ivan Dikic as a Ph.D. student. During his Ph.D., he worked on cytokine signaling pathways and inflammation response and successfully defended in September 2022.




Paulina Kettel

Paulina obtained her Bachelor's degree in Biochemistry at the University of Frankfurt while doing her Bachelor's thesis at the Paul-Ehrlich-Institut. There, she investigating the biophysics of thrombocyte membrane curvature upon binding of coagulation factors in Dr. Gerrit Praefckes lab. During her Biochemistry Master's studies she joined the lab of Prof. Daniel Fletcher at UC Berkeley as an intern working on biophysics applied to immune cell - target interfaces. After returning to University of Frankfurt, she joined the Dikic lab in November 2019 pursuing her Master's thesis by the investigation of the influence of Ubiquitin phosphorylation on ER Calcium levels during Legionella infection.




Philip Brüning

After high school in Cologne, Germany, Philip moved to Frankfurt where he studies medicine at the Goethe University of Frankfurt from 2019. Having absolved his Physikum in 2021, he started the medical doctor thesis in the Dikic group with a focus on the Role of ER-Phagy in lipid droplet biology. He continued his medical study and moved on in 2023.




Philipp Busse

Philipp started studying  Molecular Biosciences at the Goethe University in Frankfurt. After he finished his Bachelor’s degree he proceeded studying Biochemistry at the same University. He successfully did an internship in Lisbon focusing on biophysics and molecular interactions before he worked as a technician in the Paul-Ehrlich-Institute in the research group of Professor Hildt. In 2019 Philipp started working in the group of Ivan Dikic as an intern, before he officially started his Ph.D. project. He moved on in 2020.




Rajeshwari Rathore

Rajeshwari studied Microbiology at Bikaner University, India, and completed her Ph.D. at the National Chemical Laboratory, Pune. During her Ph.D. she focused on Biomarker discovery in Prediabetic clinical subjects and the mechanism of Insulin resistance, and to perform this, she used different mass spectrometry platforms. Rajeshwari joined the Dikic group in March 2021 and worked in the field of Targeted Protein Degradation (TPD). She is working on various Proxidrugs projects where she performs characterization of Target protein degraders like Molecular Glue and PROTACs using Proteomics. She left the group and returned to India at the end of 2022.




Dr. Rukmini Mukherjee

Rukmini worked as a PhD student in the lab of Dr Oishee Chakrabarti at the Saha Institute of Nuclear Physics, Kolkata. She submitted her Ph.D. thesis on E3 ligases and their importance in mitochondrial homeostasis in December 2016. Following this, she worked in the lab of Dr Tony Hunter at the Salk Institute, California. She has joined the Dikic group in October 2017 and worked on ADP-ribosylation of ubiquitin in mammalian cells. She finished her projects and moved on in 2023.




Dr. Santosh Kumar Kuncha

Santosh has completed his PhD from Center for Cellular and Molecular Biology (CCMB), Hyderabad, India under the supervision of Dr. Rajan Sankaranarayanan and which was funded by DST-INSPIRE (Dept. of Science and Technology, India) fellowship. His Ph.D. thesis was mainly focused in deciphering the “Mechanism and Physiological Role of Chiral Proofreading Modules Involved in Translation of the Genetic Code”. In the process of his Ph.D. training, he has acquired expertise in the field of structural and molecular cell biology. After a brief postdoc in India, Santosh moved to Germany to join the Dikic group to pursue the structural and physiological consequences of phosphoribosyl-ubiquitination. He move on in 2023.




MD, Stefan Prgomet

Stefan studied medicine at the University of Zagreb, Croatia, where he obtained his MD studying the role of BMP 1-3 signaling in bone fracture healing. He continued his scientific interest by joining the Dikic group in 2014 for 2 years, while he was focused on the characterization of the newly identified protein SPRTN and identified its essential role in DNA damage repair as a protease that cleaves DNA-protein-crosslinks. Subsequently he started his clinical and neurologic career first as a resident at the Clinic for Neurosurgery for 2 years and since 2019 at the Clinic for Neurology at the Goethe-University. He is in parallel continuing his scientific work at the Dr. Senckenberg Institute for Neurooncology and after achieving a fellowship from the Goethe-University Patenschaftsmodell he rejoined the Dikic group for 2020 to study the role of SPRTN and DNA-protein-crosslinks in brain tumors.




Dr. Timurs Maculins

Timurs pursued his interests in fundamental research by joining the laboratory of Karim Labib at the Manchester Cancer Research Centre in the United Kingdom after receiving a doctoral studentship from Cancer Research UK. Using the budding yeast as a model organism in his doctoral work, Timurs studied a role of a novel enzyme, known as SCFDia2 ubiquitin ligase, during DNA replication in the S phase of the cell cycle. Timurs continued his career as a postdoctoral scientist in the pharmaceutical industry in a collaborative project between the AstraZeneca High-Throughput Screening Centre and the academic laboratory headed by Ronald Hay. In late 2015 Timurs joined a collaborative project between the group of Ivan Dikic and Fraunhofer IME. Timurs has received the Human Frontier Science Program postdoctoral fellowship to study the role of ubiquitin ligase-like effectors during infection by lethal bacterial pathogens. He finished his work and moved on in 2018.




Dr. Véronique Schaeffer

Véronique did her Ph.D. in joint supervision between the University of Basel (Switzerland) and the University of Strasbourg (France), investigating the role of endogenous neurosteroids in regulating neurodegenerative processes. Afterward, Véronique worked in the group of Michel Goedert (MRC - Laboratory of Molecular Biology, Cambridge, UK), where she developed and characterized a transgenic mouse model of TDP-43 proteinopathy. She also conducted another project investigating the effect of autophagy stimulation on neurodegeneration in a mouse model of tauopathy. Véronique joined the group of Ivan Dikic, where she investigated autophagic pathways in the context of neurodiseases. She left the group in 2018.




Dr. Wenbo Chen

In July 2016 Wenbo obtained his master degree in Institute of Biophysics, Chinese Academy of Sciences, where he received preliminary training in the field of cryo-electron microscopy(cryo-EM). Afterwards Wenbo initiated his PhD study in Max-Planck-Institute of Biophysics and researched the structures of rabbit ryanodine receptor 1 (RyR1) in native membrane by cryo-EM, he will finish his PhD study in August 2020 and join the Dikic lab as postdoc researcher since September 2020. Wenbo will carry out structural studies of important proteins involved in autophagy and ubiquitylation by cryo-EM.




Dr. Yaobin Liu

Yaobin obtained his master degree in Pharmacology at Soochow University, China. Under the mentorship of Guoqiang Xu, he studied the mechanism by which Lenalidomide treats the blood cancer multiple myeloma. He joined the lab of Ivan Dikic as a PhD student in May 2016. During his PhD he is now working on the indentification of the activity and substrates of Legionella effector.




Dr. Yi-Lin Cheng

Yi-Lin obtained her Bachelor and Master degree in Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Taiwan. Afterwards, she received her PhD degree in Institute of Basic Medical Sciences, National Cheng Kung University, Taiwan in 2016. Following this, she studied on the mechanism of defective xenophagy of group A streptococcus in endothelial cells supervised by Dr. Jiunn-Jung Wu and Dr. Yee-Shin Lin as a postdoctoral fellow in Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taiwan. With great interest in the autophagy field, Yi-Lin joined the Dikic group as a postdoctoral researcher investigating the role of ER-phagy in Salmonella infection in September 2019. In August 2022, she moved to Institute of Basic Medical Sciences, National Cheng Kung University, Taiwan as an assistant professor and study the role of exosomes in bacterial infection and sepsis.

Patil PR, Burroughs AM, Misra M, Cerullo F, Insua CC, Hung HC, Dikic I, Aravind L, Joazeiro CAP Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10. Cell Rep 2023. 42 (9) 113100 Link

Mello-Vieira J, Bopp T, Dikic I Ubiquitination and cell-autonomous immunity. Curr Opin Immunol 2023. 84 102368 Link

Schierwagen R, Gu W, Brieger A, Brüne B, Ciesek S, Đikić I, Dimmeler S, Geisslinger G, Greten FR, Hermann E, Hildt E, Kempf VAJ, Klein S, Koch I, Mühl H, Müller V, Peiffer KH, Kestner RI, Piiper A, Rohde G, Scholich K, Schulz MH, Storf H, Toptan T, Vasa-Nicotera M, et al. Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure. Am J Physiol Cell Physiol 2023. 325 (1) C129-C140 Link

Pérez Berrocal DA, Vishwanatha TM, Horn-Ghetko D, Botsch JJ, Hehl LA, Kostrhon S, Misra M, Ðikić I, Geurink PP, van Dam H, Schulman BA, Mulder MPC A Pro-Fluorescent Ubiquitin-Based Probe to Monitor Cysteine-Based E3 Ligase Activity. Angew Chem Int Ed Engl 2023. 62 (32) e202303319 Link

Lamond AI, Dikic I, Nussenzweig A, Müller CW, Thornton JM, Yaffe MB The mission to ensure continued funding for excellent basic research. EMBO Rep 2023. 24 (7) e57498 Link

González A, Covarrubias-Pinto A, Bhaskara RM, Glogger M, Kuncha SK, Xavier A, Seemann E, Misra M, Hoffmann ME, Bräuning B, Balakrishnan A, Qualmann B, Dötsch V, Schulman BA, Kessels MM, Hübner CA, Heilemann M, Hummer G, Dikić I Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum. Nature 2023. 618 (7964) 394-401 Link

Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, González A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Dikić I, Hübner CA Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature 2023. 618 (7964) 402-410 Link

Patil PR, Burroughs AM, Misra M, Cerullo F, Dikic I, Aravind L, Joazeiro CAP Mechanism and evolutionary origins of Alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10. bioRxiv 2023. Link

Bhattacharya A, Mukherjee R, Kuncha SK, Brunstein ME, Rathore R, Junek S, Münch C, Dikic I A lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins. Nat Cell Biol 2023. 25 (5) 685-698 Link

Krause DS, Dikic I Mycobacterium tuberculosis hijacks ubiquitin to inhibit pyroptosis. Mol Cell 2022. 82 (24) 4588-4590 Link

Hertel A, Alves LM, Dutz H, Tascher G, Bonn F, Kaulich M, Dikic I, Eimer S, Steinberg F, Bremm A USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell Rep 2022. 41 (10) 111653 Link

Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, Schaefer L A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy. Am J Physiol Cell Physiol 2023. 324 (2) C339-C352 Link

Oo JA, Pálfi K, Warwick T, Wittig I, Prieto-Garcia C, Matkovic V, Tomašković I, Boos F, Izquierdo Ponce J, Teichmann T, Petriukov K, Haydar S, Maegdefessel L, Wu Z, Pham MD, Krishnan J, Baker AH, Günther S, Ulrich HD, Dikic I, Leisegang MS, Brandes RP Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Cell Rep 2022. 41 (7) 111670 Link

Voorneveld J, Kloet MS, Wijngaarden S, Kim RQ, Moutsiopoulou A, Verdegaal M, Misra M, Đikić I, van der Marel GA, Overkleeft HS, Filippov DV, van der Heden van Noort GJ Arginine ADP-Ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins. J Am Chem Soc 2022. 144 (45) 20582-20589 Link

Dikic I, Schulman BA An expanded lexicon for the ubiquitin code. Nat Rev Mol Cell Biol 2023. 24 (4) 273-287 Link

Shah VJ, Đikić I Localization matters in targeted protein degradation. Cell Chem Biol 2022. 29 (10) 1465-1466 Link

Mukherjee R, Dikic I Regulation of Host-Pathogen Interactions via the Ubiquitin System. Annu Rev Microbiol 2022. 76 211-233 Link

Karantanou C, Minciacchi VR, Kumar R, Zanetti C, Bravo J, Pereira RS, Tascher G, Tertel T, Covarrubias-Pinto A, Bankov K, Pfeffermann LM, Bonig H, Divieti-Pajevic P, McEwan DG, Giebel B, Münch C, Dikic I, Krause DS Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression. Blood Adv 2023. 7 (7) 1190-1203 Link

Amstein LK, Ackermann J, Hannig J, Đikić I, Fulda S, Koch I Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis. PLoS Comput Biol 2022. 18 (8) e1010383 Link

Tiku V, Kew C, Kofoed EM, Peng Y, Dikic I, Tan MW Secretes a Bioactive Lipid That Triggers Inflammatory Signaling and Cell Death. Front Microbiol 2022. 13 870101 Link

Gubas A, Dikic I ER remodeling via ER-phagy. Mol Cell 2022. 82 (8) 1492-1500 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Bozkurt S, Pahor N, Fuss C, Schirbel A, Schülein-Völk C, Buchberger A, Calzado Canale MA, Rosenfeldt M, Dikic I, Münch C, Diefenbacher ME USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K. Mol Oncol 2022. 16 (17) 3082-3106 Link

Tomaskovic I, Gonzalez A, Dikic I Ubiquitin and Legionella: From bench to bedside. Semin Cell Dev Biol 2022. 132 230-241 Link

Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J, et al. Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Ann N Y Acad Sci 2022. 1510 (1) 79-99 Link

Zhou J, Dabiri Y, Gama-Brambila RA, Ghafoory S, Altinbay M, Mehrabi A, Golriz M, Blagojevic B, Reuter S, Han K, Seidel A, Đikić I, Wölfl S, Cheng X pVHL-mediated SMAD3 degradation suppresses TGF-β signaling. J Cell Biol 2022. 221 (1) Link

Prieto-Garcia C, Tomašković I, Shah VJ, Dikic I, Diefenbacher M USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma. Cells 2021. 10 (10) Link

Schünke H, Göbel U, Dikic I, Pasparakis M OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun 2021. 12 (1) 5912 Link

Prieto-Garcia C, Hartmann O, Reissland M, Fischer T, Maier CR, Rosenfeldt M, Schülein-Völk C, Klann K, Kalb R, Dikic I, Münch C, Diefenbacher ME Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. Cell Death Differ 2022. 29 (3) 568-584 Link

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, et al. Autophagy in major human diseases. EMBO J 2021. 40 (19) e108863 Link

Maculins T, Dikic I Gasdermin B in the host-pathogen tug-of-war. Cell Res 2021. 31 (10) 1043-1044 Link

Gerstmeier J, Possmayer AL, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D, Linder B Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel) 2021. 13 (14) Link

Valečka J, Camosseto V, McEwan DG, Terawaki S, Liu Z, Strock E, Almeida CR, Su B, Dikic I, Liang Y, Gatti E, Pierre P RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages. R Soc Open Sci 2021. 8 (7) 202333 Link

Liu Y, Mukherjee R, Bonn F, Colby T, Matic I, Glogger M, Heilemann M, Dikic I Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection. Cell Death Differ 2021. 28 (10) 2957-2969 Link

Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P, Kulathu Y Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLoS One 2021. 16 (7) e0253364 Link

Schaefer L, Dikic I Autophagy: Instructions from the extracellular matrix. Matrix Biol 2021. 100-101 1-8 Link

Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour AR, Shin D, Khan KS, Hei-Yin Cheung H, Wong KB, Ng WL, Cinatl J, Geurink PP, van der Heden van Noort GJ, Rajalingam K, Ciesek S, Hummer G, Dikic I Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection. J Biol Chem 2021. 297 (2) 100925 Link

Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I, Kögel D BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells. J Cell Biochem 2022. 123 (1) 77-90 Link

Maculins T, Verschueren E, Hinkle T, Choi M, Chang P, Chalouni C, Rao S, Kwon Y, Lim J, Katakam AK, Kunz RC, Erickson BK, Huang T, Tsai TH, Vitek O, Reichelt M, Senbabaoglu Y, Mckenzie B, Rohde JR, Dikic I, Kirkpatrick DS, Murthy A Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response. Elife 2021. 10 Link

Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, et al. Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci 2021. 7 (5) 792-802 Link

Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, Kaulich M Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res 2021. 49 (10) 5684-5704 Link

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C, Dikic I SIK2 orchestrates actin-dependent host response upon infection. Proc Natl Acad Sci U S A 2021. 118 (19) Link

Kannt A, Đikić I Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation. Cell Chem Biol 2021. 28 (7) 1014-1031 Link

Gubas A, Dikic I A guide to the regulation of selective autophagy receptors. FEBS J 2022. 289 (1) 75-89 Link

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021. 17 (1) 1-382 Link

Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS, McEwan DG The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Lett 2021. 595 (7) 864-880 Link

Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I, Tan MW Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Sci Rep 2021. 11 (1) 618 Link

Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, et al. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci 2021. 22 (2) Link

Shin D, Bhattacharya A, Cheng YL, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G, Dikic I Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. Elife 2020. 9 Link

Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S Correction: Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J Biol Chem 2020. 295 (43) 14792 Link

Kim RQ, Misra M, Gonzalez A, Tomašković I, Shin D, Schindelin H, Filippov DV, Ovaa H, Đikić I, van der Heden van Noort GJ Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection. Chemistry 2021. 27 (7) 2506-2512 Link

Waidmann O, Pleli T, Weigert A, Imelmann E, Kakoschky B, Schmithals C, Döring C, Frank M, Longerich T, Köberle V, Hansmann ML, Brüne B, Zeuzem S, Piiper A, Dikic I Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis. Sci Rep 2020. 10 (1) 16264 Link

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 2020. 587 (7835) 657-662 Link

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chem Biol 2020. 27 (11) 1441-1451.e7 Link

Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh LG, Huebner AK, Cesana M, Bonn F, Polishchuk E, Hübner CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. EMBO J 2020. 39 (17) e105696 Link

Tiku V, Tan MW, Dikic I Mitochondrial Functions in Infection and Immunity: (Trends in Cell Biology 30, 263-275, 2020). Trends Cell Biol 2020. 30 (9) 748 Link

Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codée JDC, Filippov DV, van der Heden van Noort GJ Synthesis of Stable NAD Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC. Chembiochem 2020. 21 (20) 2903-2907 Link

Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I, Ernst A Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine. Front Cell Dev Biol 2020. 8 208 Link

Tiku V, Tan MW, Dikic I Mitochondrial Functions in Infection and Immunity. Trends Cell Biol 2020. 30 (4) 263-275 Link

Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J, Dikic I Wss1 Promotes Replication Stress Tolerance by Degrading Histones. Cell Rep 2020. 30 (9) 3117-3126.e4 Link

Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I, Heilemann M Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells. Sci Signal 2020. 13 (614) Link

Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Mol Cell 2020. 77 (1) 164-179.e6 Link

Pohl C, Dikic I Cellular quality control by the ubiquitin-proteasome system and autophagy. Science 2019. 366 (6467) 818-822 Link

Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease. EMBO Rep 2020. 21 (1) e48317 Link

Hübner CA, Dikic I ER-phagy and human diseases. Cell Death Differ 2020. 27 (3) 833-842 Link

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. Nature 2019. 572 (7769) 382-386 Link

Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nat Microbiol 2019. 4 (9) 1516-1531 Link

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J Mol Biol 2019. 431 (17) 3146-3156 Link

Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy. Nat Commun 2019. 10 (1) 2370 Link

Mukherjee R, Dikic I NIPSNAP Beacons in Mitophagy. Dev Cell 2019. 49 (4) 503-505 Link

Misra M, Dikic I RNA binding to p62 impacts selective autophagy. Cell Res 2019. 29 (7) 512-513 Link

Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5. Autophagy 2020. 16 (2) 256-270 Link

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science 2019. 364 (6436) 188-193 Link

Tiku V, Dikic I Autophagy without conjugation. Nat Struct Mol Biol 2019. 26 (4) 249-250 Link

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling. Cancers (Basel) 2019. 11 (3) Link

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife 2019. 8 Link

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int 2019. 95 (3) 540-562 Link

van Wijk SJ, Fulda S, Dikic I, Heilemann M Visualizing ubiquitination in mammalian cells. EMBO Rep 2019. 20 (2) Link

Juretschke T, Beli P, Dikic I Quantitative Phosphoproteomics of Selective Autophagy Receptors. Methods Mol Biol 2019. 1880 691-701 Link

Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M The next decade of metabolism. Nat Metab 2019. 1 (1) 2-4 Link

Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J 2019. 38 (2) Link

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep 2018. 19 (12) Link

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood 2019. 133 (2) 168-179 Link

Dikic I Open questions: why should we care about ER-phagy and ER remodelling? BMC Biol 2018. 16 (1) 131 Link

Herhaus L, Dikic I Dimerization quality control via ubiquitylation. Science 2018. 362 (6411) 151-152 Link

Stolz A, Dikic I Elusive mitochondrial connection to inflammation uncovered. Nature 2018. 561 (7722) 185-186 Link

Grumati P, Dikic I, Stolz A ER-phagy at a glance. J Cell Sci 2018. 131 (17) Link

Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Nature 2018. 557 (7707) 734-738 Link

Münch C, Dikic I Publisher Correction: Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (8) 990 Link

Dikic I, Elazar Z Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol 2018. 19 (6) 349-364 Link

Herhaus L, Dikic I Ubiquitin-induced phase separation of p62/SQSTM1. Cell Res 2018. 28 (4) 389-390 Link

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells. Neoplasia 2018. 20 (3) 263-279 Link

Münch C, Dikic I Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (2) 122-124 Link

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Structure 2018. 26 (2) 249-258.e4 Link

Ramadan K, Dikic I Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response. Front Genet 2017. 8 188 Link

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angew Chem Int Ed Engl 2018. 57 (6) 1659-1662 Link

Stolz A, Dikic I Heterotypic Ubiquitin Chains: Seeing is Believing. Trends Cell Biol 2018. 28 (1) 1-3 Link

Grumati P, Dikic I Ubiquitin signaling and autophagy. J Biol Chem 2018. 293 (15) 5404-5413 Link

Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring. Proc Natl Acad Sci U S A 2017. 114 (49) 13042-13047 Link

Herhaus L, Dikic I Regulation of Salmonella-host cell interactions via the ubiquitin system. Int J Med Microbiol 2018. 308 (1) 176-184 Link

Amstein L, Ackermann J, Scheidel J, Fulda S, Dikic I, Koch I Manatee invariants reveal functional pathways in signaling networks. BMC Syst Biol 2017. 11 (1) 72 Link

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep 2017. 18 (8) 1382-1396 Link

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. Elife 2017. 6 Link

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, et al. Molecular definitions of autophagy and related processes. EMBO J 2017. 36 (13) 1811-1836 Link

Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell 2017. 66 (4) 517-532.e9 Link

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation. Nat Microbiol 2017. 2 17066 Link

Dikic I Proteasomal and Autophagic Degradation Systems. Annu Rev Biochem 2017. 86 193-224 Link

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. Sci Rep 2017. 7 (1) 1131 Link

Šprung M, Dikic I, Novak I Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy. Methods Mol Biol 2018. 1759 105-110 Link

Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R, et al. Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Res 2017. 27 (5) 657-674 Link

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife 2017. 6 Link

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Nat Commun 2017. 8 14004 Link

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 2017. 214 (2) 423-437 Link

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO J 2017. 36 (4) 549-564 Link

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Cell 2016. 167 (6) 1636-1649.e13 Link

Tooze SA, Dikic I Autophagy Captures the Nobel Prize. Cell 2016. 167 (6) 1433-1435 Link

Scheidel J, Amstein L, Ackermann J, Dikic I, Koch I In Silico Knockout Studies of Xenophagic Capturing of Salmonella. PLoS Comput Biol 2016. 12 (12) e1005200 Link

Seczynska M, Dikic I Removing the waste bags: how p97 drives autophagy of lysosomes. EMBO J 2017. 36 (2) 129-131 Link

Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Elife 2016. 5 Link

Hoeller D, Dikic I How the proteasome is degraded. Proc Natl Acad Sci U S A 2016. 113 (47) 13266-13268 Link

Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. Diabetes 2016. 65 (12) 3667-3679 Link

Weishaupt JH, Hyman T, Dikic I Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Trends Mol Med 2016. 22 (9) 769-783 Link

Fiskin E, Bionda T, Dikic I, Behrends C Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Mol Cell 2016. 62 (6) 967-981 Link

Bhogaraju S, Dikic I Cell biology: Ubiquitination without E1 and E2 enzymes. Nature 2016. 533 (7601) 43-4 Link

Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. FEBS J 2016. 283 (11) 2004-17 Link

Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A 2016. 113 (15) 4039-44 Link

Baccarini M, Dikic I Editorial overview: Cell regulation. Curr Opin Cell Biol 2016. 39 iv-vi Link

Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, Schaefer L An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. Am J Pathol 2016. 186 (5) 1206-20 Link

Maculins T, Fiskin E, Bhogaraju S, Dikic I Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res 2016. 26 (4) 499-510 Link

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget 2016. 7 (15) 20016-32 Link

Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. J Biol Chem 2016. 291 (17) 9025-41 Link

Rajalingam K, Dikic I SnapShot: Expanding the Ubiquitin Code. Cell 2016. 164 (5) 1074-1074.e1 Link

Akutsu M, Dikic I, Bremm A Ubiquitin chain diversity at a glance. J Cell Sci 2016. 129 (5) 875-80 Link

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016. 12 (1) 1-222 Link

Gomes LC, Odedra D, Dikic I, Pohl C Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans. Autophagy 2016. 12 (3) 529-46 Link

Kern A, Dikic I, Behl C The integration of autophagy and cellular trafficking pathways via RAB GAPs. Autophagy 2015. 11 (12) 2393-7 Link

Khaminets A, Behl C, Dikic I Ubiquitin-Dependent And Independent Signals In Selective Autophagy. Trends Cell Biol 2016. 26 (1) 6-16 Link

Herhaus L, Dikic I Expanding the ubiquitin code through post-translational modification. EMBO Rep 2015. 16 (9) 1071-83 Link

Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S Binding of SGTA to Rpn13 selectively modulates protein quality control. J Cell Sci 2015. 128 (17) 3187-96 Link

Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 2015. 522 (7556) 354-8 Link

McEwan DG, Dikic I PLEKHM1: Adapting to life at the lysosome. Autophagy 2015. 11 (4) 720-2 Link

Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, et al. Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci 2015. 18 (5) 631-6 Link

McEwan DG, Dikic I Cullins keep autophagy under control. Dev Cell 2014. 31 (6) 675-6 Link

Stolz A, Dikic I PINK1-PARKIN interplay: down to ubiquitin phosphorylation. Mol Cell 2014. 56 (3) 341-342 Link

McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection. Cell Host Microbe 2015. 17 (1) 58-71 Link

McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol Cell 2015. 57 (1) 39-54 Link

Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy 2014. 10 (12) 2297-309 Link

Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife 2014. 3 Link

Popovic D, Vucic D, Dikic I Ubiquitination in disease pathogenesis and treatment. Nat Med 2014. 20 (11) 1242-53 Link

Dikic I, Bremm A DUBs counteract parkin for efficient mitophagy. EMBO J 2014. 33 (21) 2442-3 Link

Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, et al. Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet 2014. 46 (11) 1239-44 Link

Bhogaraju S, Dikic I A peek into the atomic details of thalidomide's clinical effects. Nat Struct Mol Biol 2014. 21 (9) 739-40 Link

Stolz A, Ernst A, Dikic I Cargo recognition and trafficking in selective autophagy. Nat Cell Biol 2014. 16 (6) 495-501 Link

López-Mosqueda J, Dikic I Deciphering functions of branched ubiquitin chains. Cell 2014. 157 (4) 767-9 Link

Gomes LC, Dikic I Autophagy in antimicrobial immunity. Mol Cell 2014. 54 (2) 224-33 Link

Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling. Mol Cell 2014. 54 (3) 349-61 Link

Grumati P, Dikic I Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling. Cancer Discov 2014. 4 (4) 394-6 Link

Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chem Biol 2014. 21 (4) 552-562 Link

Popovic D, Dikic I TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO Rep 2014. 15 (4) 392-401 Link

Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente. EMBO Rep 2014. 15 (1) 7-11 Link

Piper RC, Dikic I, Lukacs GL Ubiquitin-dependent sorting in endocytosis. Cold Spring Harb Perspect Biol 2014. 6 (1) Link

Wild P, McEwan DG, Dikic I The LC3 interactome at a glance. J Cell Sci 2014. 127 (Pt 1) 3-9 Link

Putyrski M, Dikic I Breaking the limits of artificial ubiquitination. Proc Natl Acad Sci U S A 2013. 110 (44) 17606-7 Link

Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature 2013. 503 (7476) 422-426 Link

van Wijk SJ, Fiškin E, Dikic I Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors. Nat Protoc 2013. 8 (7) 1449-58 Link

Rogov VV, Suzuki H, Fiskin E, Wild P, Kniss A, Rozenknop A, Kato R, Kawasaki M, McEwan DG, Löhr F, Güntert P, Dikic I, Wakatsuki S, Dötsch V Structural basis for phosphorylation-triggered autophagic clearance of Salmonella. Biochem J 2013. 454 (3) 459-66 Link

Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. Dev Cell 2013. 25 (1) 15-28 Link

Olma MH, Dikic I Cullins getting undressed by the protein exchange factor Cand1. Cell 2013. 153 (1) 14-6 Link

Fiškin E, Dikic I Parkin promotes cell survival via linear ubiquitination. EMBO J 2013. 32 (8) 1072-4 Link

Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods 2013. 10 (4) 361-5 Link

Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem 2013. 288 (2) 1099-113 Link

Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J Cell Sci 2013. 126 (Pt 2) 580-92 Link

Verhelst K, Carpentier I, Kreike M, Meloni L, Verstrepen L, Kensche T, Dikic I, Beyaert R A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J 2012. 31 (19) 3845-55 Link

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012. 8 (4) 445-544 Link

Rizvi H, Paterson JC, Tedoldi S, Ramsay A, Calaminici M, Natkunam Y, Lonardi S, Tan SY, Campbell L, Hansmann ML, Jones D, Dikic I, Shaw AS, Pileri SA, Stein H, Mason DY, Facchetti F, Marafioti T Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue. Pathologica 2012. 104 (2) 56-64 Link

Pohl C, Dikic I Fighting mycobacteria through ISGylation. EMBO Rep 2012. 13 (10) 872-3 Link

Belgnaoui SM, Paz S, Samuel S, Goulet ML, Sun Q, Kikkert M, Iwai K, Dikic I, Hiscott J, Lin R Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe 2012. 12 (2) 211-22 Link

van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol Cell 2012. 47 (5) 797-809 Link

Fulda S, Rajalingam K, Dikic I Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications. EMBO Mol Med 2012. 4 (7) 545-56 Link

Shaid S, Brandts CH, Serve H, Dikic I Ubiquitination and selective autophagy. Cell Death Differ 2013. 20 (1) 21-30 Link

Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. J Biol Chem 2012. 287 (28) 23626-34 Link

Rahighi S, Dikic I Selectivity of the ubiquitin-binding modules. FEBS Lett 2012. 586 (17) 2705-10 Link

Stieglitz B, Haire LF, Dikic I, Rittinger K Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold. J Biol Chem 2012. 287 (25) 20823-9 Link

Husnjak K, Dikic I Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem 2012. 81 291-322 Link

Rogov VV, Rozenknop A, Rogova NY, Löhr F, Tikole S, Jaravine V, Güntert P, Dikic I, Dötsch V A universal expression tag for structural and functional studies of proteins. Chembiochem 2012. 13 (7) 959-63 Link

Walczak H, Iwai K, Dikic I Generation and physiological roles of linear ubiquitin chains. BMC Biol 2012. 10 23 Link

Dikic I, Robertson M Ubiquitin ligases and beyond. BMC Biol 2012. 10 22 Link

Dikic I Ivan Dikic was trained as a medical doctor at the University of Zagreb, Croatia. Curr Biol 2012. 22 (3) R76-7 Link

Haglund K, Dikic I The role of ubiquitylation in receptor endocytosis and endosomal sorting. J Cell Sci 2012. 125 (Pt 2) 265-75 Link

Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol 2012. 32 (9) 1733-44 Link

Dikic I, Daly RJ Signalling through the grapevine. EMBO Rep 2012. 13 (3) 178-80 Link

van Wijk SJ, Bienko M, Dikic I Role of UbL family modifiers and their binding proteins in cell signaling. Methods Mol Biol 2012. 832 163-71 Link

Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S Structure of a compact conformation of linear diubiquitin. Acta Crystallogr D Biol Crystallogr 2012. 68 (Pt 2) 102-8 Link

Pareja F, Ferraro DA, Rubin C, Cohen-Dvashi H, Zhang F, Aulmann S, Ben-Chetrit N, Pines G, Navon R, Crosetto N, Köstler W, Carvalho S, Lavi S, Schmitt F, Dikic I, Yakhini Z, Sinn P, Mills GB, Yarden Y Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. Oncogene 2012. 31 (43) 4599-608 Link

Sandilands E, Serrels B, McEwan DG, Morton JP, Macagno JP, McLeod K, Stevens C, Brunton VG, Langdon WY, Vidal M, Sansom OJ, Dikic I, Wilkinson S, Frame MC Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol 2011. 14 (1) 51-60 Link

van Wijk SJ, Müller S, Dikic I Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair. Genes Dev 2011. 25 (17) 1763-9 Link

Rahighi S, Dikic I Conformational flexibility and rotation of the RING domain in activation of cullin-RING ligases. Nat Struct Mol Biol 2011. 18 (8) 863-5 Link

Rajalingam K, Dikic I Healthy ageing through regulated proteostasis. EMBO J 2011. 30 (15) 2983-5 Link

Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1. J Mol Biol 2011. 410 (3) 477-87 Link

Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 2011. 333 (6039) 228-33 Link

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 2011. 471 (7340) 637-41 Link

Grabbe C, Husnjak K, Dikic I The spatial and temporal organization of ubiquitin networks. Nat Rev Mol Cell Biol 2011. 12 (5) 295-307 Link

Mendl N, Occhipinti A, Müller M, Wild P, Dikic I, Reichert AS Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2. J Cell Sci 2011. 124 (Pt 8) 1339-50 Link

McEwan DG, Dikic I The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol 2011. 21 (4) 195-201 Link

Hoeller D, Dikic I Regulation of ubiquitin receptors by coupled monoubiquitination. Subcell Biochem 2010. 54 31-40 Link

Novak I, Dikic I Autophagy receptors in developmental clearance of mitochondria. Autophagy 2011. 7 (3) 301-3 Link

Ikeda F, Rahighi S, Wakatsuki S, Dikic I Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation. Adv Exp Med Biol 2011. 691 107-14 Link

Ikeda F, Crosetto N, Dikic I What determines the specificity and outcomes of ubiquitin signaling? Cell 2010. 143 (5) 677-81 Link

Kirkin V, Dikic I Ubiquitin networks in cancer. Curr Opin Genet Dev 2011. 21 (1) 21-8 Link

Suzuki N, Hiraki M, Yamada Y, Matsugaki N, Igarashi N, Kato R, Dikic I, Drew D, Iwata S, Wakatsuki S, Kawasaki M Crystallization of small proteins assisted by green fluorescent protein. Acta Crystallogr D Biol Crystallogr 2010. 66 (Pt 10) 1059-66 Link

Bethani I, Skånland SS, Dikic I, Acker-Palmer A Spatial organization of transmembrane receptor signalling. EMBO J 2010. 29 (16) 2677-88 Link

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, et al. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J 2010. 29 (14) 2421-32 Link

Deribe YL, Pawson T, Dikic I Post-translational modifications in signal integration. Nat Struct Mol Biol 2010. 17 (6) 666-72 Link

Dikic I, Schmidt MHH Notch: Implications of endogenous inhibitors for therapy. Bioessays 2010. 32 (6) 481-487 Link

McEwan DG, Dikic I Not all autophagy membranes are created equal. Cell 2010. 141 (4) 564-6 Link

Haglund K, Nezis IP, Lemus D, Grabbe C, Wesche J, Liestøl K, Dikic I, Palmer R, Stenmark H Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. Curr Biol 2010. 20 (10) 944-50 Link

Dikic I, Johansen T, Kirkin V Selective autophagy in cancer development and therapy. Cancer Res 2010. 70 (9) 3431-4 Link

Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proc Natl Acad Sci U S A 2010. 107 (14) 6459-64 Link

Bomar MG, D'Souza S, Bienko M, Dikic I, Walker GC, Zhou P Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. Mol Cell 2010. 37 (3) 408-17 Link

Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell 2010. 37 (3) 396-407 Link

Wild P, Dikic I Mitochondria get a Parkin' ticket. Nat Cell Biol 2010. 12 (2) 104-6 Link

Nagy V, Dikic I Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity. Biol Chem 2010. 391 (2-3) 163-169 Link

Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MHH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal 2009. 2 (102) ra84 Link

Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichert AS, Terzic J, Dötsch V, Ney PA, Dikic I Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep 2010. 11 (1) 45-51 Link

Dikic I, Dötsch V Ubiquitin linkages make a difference. Nat Struct Mol Biol 2009. 16 (12) 1209-10 Link

Dikic I, Wakatsuki S, Walters KJ Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol 2009. 10 (10) 659-71 Link

Lappe-Siefke C, Loebrich S, Hevers W, Waidmann OB, Schweizer M, Fehr S, Fritschy JM, Dikic I, Eilers J, Wilson SM, Kneussel M The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLoS Genet 2009. 5 (9) e1000631 Link

Schmidt MHH, Bicker F, Nikolic I, Meister J, Babuke T, Picuric S, Müller-Esterl W, Plate KH, Dikic I Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol 2009. 11 (7) 873-80 Link

Lamark T, Kirkin V, Dikic I, Johansen T NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 2009. 8 (13) 1986-90 Link

Kirkin V, McEwan DG, Novak I, Dikic I A role for ubiquitin in selective autophagy. Mol Cell 2009. 34 (3) 259-69 Link

Kirkin V, Lamark T, Johansen T, Dikic I NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009. 5 (5) 732-3 Link

Dikic I Journal club. A new ubiquitin chain, a new signal. Nat Rev Mol Cell Biol 2009. 10 (5) 306 Link

Hoeller D, Dikic I Targeting the ubiquitin system in cancer therapy. Nature 2009. 458 (7237) 438-44 Link

Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 2009. 136 (6) 1098-109 Link

Grabbe C, Dikic I Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins. Chem Rev 2009. 109 (4) 1481-94 Link

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009. 33 (4) 505-16 Link

Sabbioneda S, Green CM, Bienko M, Kannouche P, Dikic I, Lehmann AR Ubiquitin-binding motif of human DNA polymerase eta is required for correct localization. Proc Natl Acad Sci U S A 2009. 106 (8) E20; author reply E21 Link

Scharner D, Rössig L, Carmona G, Chavakis E, Urbich C, Fischer A, Kang TB, Wallach D, Chiang YJ, Deribe YL, Dikic I, Zeiher AM, Dimmeler S Caspase-8 is involved in neovascularization-promoting progenitor cell functions. Arterioscler Thromb Vasc Biol 2009. 29 (4) 571-8 Link

Rajalingam K, Dikic I Inhibitors of apoptosis catch ubiquitin. Biochem J 2009. 417 (1) e1-3 Link

Grabbe C, Dikic I Cell biology. Going global on ubiquitin. Science 2008. 322 (5903) 872-3 Link

Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem 2008. 283 (50) 35173-85 Link

Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J Reply to "The binding stoichiometry of CIN85 SH3 domain A and Cbl-b". Nat Struct Mol Biol 2008. 15 (9) 891-2 Link

Nonis D, Schmidt MHH, van de Loo S, Eich F, Dikic I, Nowock J, Auburger G Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. Cell Signal 2008. 20 (10) 1725-39 Link

Ikeda F, Dikic I Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep 2008. 9 (6) 536-42 Link

Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature 2008. 453 (7194) 548-52 Link

Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 2008. 453 (7194) 481-8 Link

Schmidt-Glenewinkel H, Vacheva I, Hoeller D, Dikic I, Eils R An ultrasensitive sorting mechanism for EGF receptor endocytosis. BMC Syst Biol 2008. 2 32 Link

Zagrovic B, Dikic I Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe. Nat Rev Mol Cell Biol 2008. 9 (4) 333-6 Link

Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J 2008. 27 (4) 629-41 Link

Marafioti T, Paterson JC, Ballabio E, Reichard KK, Tedoldi S, Hollowood K, Dictor M, Hansmann ML, Pileri SA, Dyer MJ, Sozzani S, Dikic I, Shaw AS, Petrella T, Stein H, Isaacson PG, Facchetti F, Mason DY Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood 2008. 111 (7) 3778-92 Link

Bloor S, Ryzhakov G, Wagner S, Butler PJ, Smith DL, Krumbach R, Dikic I, Randow F Signal processing by its coil zipper domain activates IKK gamma. Proc Natl Acad Sci U S A 2008. 105 (4) 1279-84 Link

Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 2008. 27 (26) 3739-45 Link

Guo C, Tang TS, Bienko M, Dikic I, Friedberg EC Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance. J Biol Chem 2008. 283 (8) 4658-64 Link

Terzic J, Marinovic-Terzic I, Ikeda F, Dikic I Ubiquitin signals in the NF-kappaB pathway. Biochem Soc Trans 2007. 35 (Pt 5) 942-5 Link

Raguz J, Wagner S, Dikic I, Hoeller D Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. FEBS Lett 2007. 581 (24) 4767-72 Link

Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 2007. 26 (14) 3451-62 Link

Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell 2007. 26 (6) 891-8 Link

Dikic I, Schmidt MHH Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. Eur J Cell Biol 2007. 86 (9) 505-12 Link

Sargin B, Choudhary C, Crosetto N, Schmidt MHH, Grundler R, Rensinghoff M, Thiessen C, Tickenbrock L, Schwäble J, Brandts C, August B, Koschmieder S, Bandi SR, Duyster J, Berdel WE, Müller-Tidow C, Dikic I, Serve H Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood 2007. 110 (3) 1004-12 Link

Kirkin V, Dikic I Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr Opin Cell Biol 2007. 19 (2) 199-205 Link

Parker JL, Bielen AB, Dikic I, Ulrich HD Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res 2007. 35 (3) 881-9 Link

Tossidou I, Kardinal C, Peters I, Kriz W, Shaw A, Dikic I, Tkachuk S, Dumler I, Haller H, Schiffer M CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes. J Biol Chem 2007. 282 (10) 7457-64 Link

Crosetto N, Bienko M, Dikic I Ubiquitin hubs in oncogenic networks. Mol Cancer Res 2006. 4 (12) 899-904 Link

Schmidt MHH, Dikic I Ubiquitin and NEDD8: brothers in arms. Sci STKE 2006. 2006 (362) .pe50 Link

Dikic I, Crosetto N, Calatroni S, Bernasconi P Targeting ubiquitin in cancers. Eur J Cancer 2006. 42 (18) 3095-102 Link

Moncalián G, Cárdenes N, Deribe YL, Spínola-Amilibia M, Dikic I, Bravo J Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem 2006. 281 (50) 38845-53 Link

Hoeller D, Hecker CM, Dikic I Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 2006. 6 (10) 776-88 Link

Guo C, Tang TS, Bienko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol 2006. 26 (23) 8892-900 Link

Husnjak K, Dikic I EGFR trafficking: parkin' in a jam. Nat Cell Biol 2006. 8 (8) 787-8 Link

Seet BT, Dikic I, Zhou MM, Pawson T Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol 2006. 7 (7) 473-83 Link

Schmidt MHH, Dikic I Assays to monitor degradation of the EGF receptor. Methods Mol Biol 2006. 327 131-8 Link

Ikeda F, Dikic I CYLD in ubiquitin signaling and tumor pathogenesis. Cell 2006. 125 (4) 643-5 Link

Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem 2006. 281 (23) 16117-27 Link

Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol 2006. 8 (2) 163-9 Link

Schmidt MHH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix. Oncogene 2006. 25 (21) 3071-8 Link

Katic M, Bosnjak B, Gall-Troselj K, Dikic I, Pavelic K A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro. Front Biosci 2006. 11 1722-32 Link

Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005. 310 (5755) 1821-4 Link

Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. Biochem Biophys Res Commun 2005. 338 (2) 808-14 Link

Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J Cbl promotes clustering of endocytic adaptor proteins. Nat Struct Mol Biol 2005. 12 (11) 972-9 Link

Schmidt MHH, Dikic I The Cbl interactome and its functions. Nat Rev Mol Cell Biol 2005. 6 (12) 907-18 Link

Molfetta R, Belleudi F, Peruzzi G, Morrone S, Leone L, Dikic I, Piccoli M, Frati L, Torrisi MR, Santoni A, Paolini R CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function. J Immunol 2005. 175 (7) 4208-16 Link

Haglund K, Dikic I Ubiquitylation and cell signaling. EMBO J 2005. 24 (19) 3353-9 Link

Eckerdt F, Yuan J, Saxena K, Martin B, Kappel S, Lindenau C, Kramer A, Naumann S, Daum S, Fischer G, Dikic I, Kaufmann M, Strebhardt K Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells. J Biol Chem 2005. 280 (44) 36575-83 Link

Sulić S, Panić L, Dikić I, Volarević S Deregulation of cell growth and malignant transformation. Croat Med J 2005. 46 (4) 622-38 Link

Haglund K, Schmidt MHH, Wong ES, Guy GR, Dikic I Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep 2005. 6 (7) 635-41 Link

Crosetto N, Tikkanen R, Dikic I Oncogenic breakdowns in endocytic adaptor proteins. FEBS Lett 2005. 579 (15) 3231-8 Link

Hoeller D, Volarevic S, Dikic I Compartmentalization of growth factor receptor signalling. Curr Opin Cell Biol 2005. 17 (2) 107-11 Link

Shimokawa N, Dikic I, Sugama S, Koibuchi N Molecular responses to acidosis of central chemosensitive neurons in brain. Cell Signal 2005. 17 (7) 799-808 Link

Banno Y, Ohguchi K, Matsumoto N, Koda M, Ueda M, Hara A, Dikic I, Nozawa Y Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells. J Biol Chem 2005. 280 (16) 16319-24 Link

Schmidt MHH, Dikic I, Bögler O Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. J Biol Chem 2005. 280 (5) 3414-25 Link

Schmidt MHH, Hoeller D, Yu J, Furnari FB, Cavenee WK, Dikic I, Bögler O Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol 2004. 24 (20) 8981-93 Link

Szymkiewicz I, Shupliakov O, Dikic I Cargo- and compartment-selective endocytic scaffold proteins. Biochem J 2004. 383 (Pt 1) 1-11 Link

Dikic I ALIX-ing phospholipids with endosome biogenesis. Bioessays 2004. 26 (6) 604-7 Link

Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem 2004. 279 (31) 32786-95 Link

Szymkiewicz I, Destaing O, Jurdic P, Dikic I SH3P2 in complex with Cbl and Src. FEBS Lett 2004. 565 (1-3) 33-8 Link

Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci 2004. 117 (Pt 12) 2557-68 Link

Shimokawa N, Qiu CH, Seki T, Dikic I, Koibuchi N Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression. Cell Signal 2004. 16 (6) 723-9 Link

Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA, Dikic I CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell 2004. 15 (7) 3155-66 Link

Höller D, Dikic I Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem Pharmacol 2004. 67 (6) 1013-7 Link

Dikic I Mechanisms controlling EGF receptor endocytosis and degradation. Biochem Soc Trans 2003. 31 (Pt 6) 1178-81 Link

Haglund K, Di Fiore PP, Dikic I Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci 2003. 28 (11) 598-603 Link

Kowanetz K, Terzic J, Dikic I Dab2 links CIN85 with clathrin-mediated receptor internalization. FEBS Lett 2003. 554 (1-2) 81-7 Link

Dikic I, Szymkiewicz I, Soubeyran P Cbl signaling networks in the regulation of cell function. Cell Mol Life Sci 2003. 60 (9) 1805-27 Link

Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem 2003. 278 (41) 39735-46 Link

Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore PP, Dikic I Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol 2003. 5 (5) 461-6 Link

Dikic I, Giordano S Negative receptor signalling. Curr Opin Cell Biol 2003. 15 (2) 128-35 Link

Piiper A, Lutz MP, Cramer H, Elez R, Kronenberger B, Dikic I, Müller-Esterl W, Zeuzem S Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor. Biochem Biophys Res Commun 2003. 301 (4) 848-54 Link

Soubeyran P, Barac A, Szymkiewicz I, Dikic I Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. Biochem J 2003. 370 (Pt 1) 29-34 Link

Shimokawa N, Okada J, Haglund K, Dikic I, Koibuchi N, Miura M Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain. J Neurosci 2002. 22 (21) 9160-5 Link

Dikic I CIN85/CMS family of adaptor molecules. FEBS Lett 2002. 529 (1) 110-5 Link

Haglund K, Shimokawa N, Szymkiewicz I, Dikic I Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Proc Natl Acad Sci U S A 2002. 99 (19) 12191-6 Link

Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J Biol Chem 2002. 277 (46) 43623-30 Link

Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. J Biol Chem 2002. 277 (42) 39666-72 Link

Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 2002. 416 (6877) 183-7 Link

Sajan MP, Bandyopadhyay G, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D. Biochem J 2002. 362 (Pt 3) 665-74 Link

Picascia A, Stanzione R, Chieffi P, Kisslinger A, Dikic I, Tramontano D Proline-rich tyrosine kinase 2 regulates proliferation and differentiation of prostate cells. Mol Cell Endocrinol 2002. 186 (1) 81-7 Link

Pizard A, Blaukat A, Michineau S, Dikic I, Müller-Esterl W, Alhenc-Gelas F, Rajerison RM Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy. Biochemistry 2001. 40 (51) 15743-51 Link

Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. J Biol Chem 2001. 276 (44) 40431-40 Link

Soubeyran P, Haglund K, Garcia S, Barth BU, Iovanna J, Dikic I Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells. Oncogene 2001. 20 (31) 4180-7 Link

Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. J Biol Chem 2001. 276 (38) 35537-45 Link

Pavelić K, Hadzija M, Bedrica L, Pavelić J, Dikić I, Katić M, Kralj M, Bosnar MH, Kapitanović S, Poljak-Blazi M, Krizanac S, Stojković R, Jurin M, Subotić B, Colić M Natural zeolite clinoptilolite: new adjuvant in anticancer therapy. J Mol Med (Berl) 2001. 78 (12) 708-20 Link

Blaukat A, Dikic I Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. Biol Chem 2001. 382 (1) 135-9 Link

Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Burke TR, Quon MJ, Reed BC, Dikic I, Noel LE, Newgard CB, Farese R Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. J Biol Chem 2000. 275 (52) 40817-26 Link

Ivankovic-Dikic I, Grönroos E, Blaukat A, Barth BU, Dikic I Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nat Cell Biol 2000. 2 (9) 574-81 Link

Blaukat A, Barac A, Cross MJ, Offermanns S, Dikic I G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals. Mol Cell Biol 2000. 20 (18) 6837-48 Link

Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem 2000. 275 (38) 29338-47 Link

Soubeyran P, André F, Lissitzky JC, Mallo GV, Moucadel V, Roccabianca M, Rechreche H, Marvaldi J, Dikic I, Dagorn JC, Iovanna JL Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology 1999. 117 (6) 1326-38 Link

Dikić I, Pavelić K Dubrovnik Conference on Signal Transduction: an opportunity for education of young scientists. Acta Med Croatica 1999. 53 (1) 1-4 Link

Dikic I, Blaukat A Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling. Cell Biochem Biophys 1999. 30 (3) 369-87 Link

Blaukat A, Pizard A, Rajerison RM, Alhenc-Gelas F, Müller-Esterl W, Dikic I Activation of mitogen-activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization. FEBS Lett 1999. 451 (3) 337-41 Link

Yamashita H, Avraham S, Jiang S, Dikic I, Avraham H The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. J Biol Chem 1999. 274 (21) 15059-65 Link

Blaukat A, Ivankovic-Dikic I, Grönroos E, Dolfi F, Tokiwa G, Vuori K, Dikic I Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J Biol Chem 1999. 274 (21) 14893-901 Link

Dikic I, Dikic I, Schlessinger J Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling. J Biol Chem 1998. 273 (23) 14301-8 Link

Miyazaki T, Takaoka A, Nogueira L, Dikic I, Fujii H, Tsujino S, Mitani Y, Maeda M, Schlessinger J, Taniguchi T Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway. Genes Dev 1998. 12 (6) 770-5 Link

Davis CB, Dikic I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med 1997. 186 (10) 1793-8 Link

Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J Exp Med 1997. 185 (7) 1253-9 Link

Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996. 383 (6600) 547-50 Link

Tokiwa G, Dikic I, Lev S, Schlessinger J Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 1996. 273 (5276) 792-4 Link

Mohammadi M, Dikic I, Sorokin A, Burgess WH, Jaye M, Schlessinger J Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol Cell Biol 1996. 16 (3) 977-89 Link

Dikić I Regulation of HIV-1 infection by chemokine receptors. Acta Med Croatica 1996. 50 (4-5) 163-8 Link

Galisteo ML, Dikic I, Batzer AG, Langdon WY, Schlessinger J Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J Biol Chem 1995. 270 (35) 20242-5 Link

Dikic I, Batzer AG, Blaikie P, Obermeier A, Ullrich A, Schlessinger J, Margolis B Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain. J Biol Chem 1995. 270 (25) 15125-9 Link

Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell 1994. 79 (6) 1015-24 Link

Dikic I, Schlessinger J, Lax I PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr Biol 1994. 4 (8) 702-8 Link

Marusić A, Dikić I, Vukicević S, Marusić M New bone induction by demineralized bone matrix in immunosuppressed rats. Experientia 1992. 48 (8) 783-5 Link

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