Publications from PubMed: 314
Gerstmeier J, Possmayer AL, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D, Linder B
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide.
Cancers (Basel)
2021.
13
(14)
Link
Valečka J, Camosseto V, McEwan DG, Terawaki S, Liu Z, Strock E, Almeida CR, Su B, Dikic I, Liang Y, Gatti E, Pierre P
RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.
R Soc Open Sci
2021.
8
(7)
202333
Link
Liu Y, Mukherjee R, Bonn F, Colby T, Matic I, Glogger M, Heilemann M, Dikic I
Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection.
Cell Death Differ
2021.
Link
Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P, Kulathu Y
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
PLoS One
2021.
16
(7)
e0253364
Link
Schaefer L, Dikic I
Autophagy: Instructions from the extracellular matrix.
Matrix Biol
2021.
Link
Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour AR, Shin D, Khan KS, Hei-Yin Cheung H, Wong KB, Ng WL, Cinatl J, Geurink PP, van der Heden van Noort GJ, Rajalingam K, Ciesek S, Hummer G, Dikic I
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection.
J Biol Chem
2021.
297
(2)
100925
Link
Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I, Kögel D
BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells.
J Cell Biochem
2021.
Link
Maculins T, Verschueren E, Hinkle T, Choi M, Chang P, Chalouni C, Rao S, Kwon Y, Lim J, Katakam AK, Kunz RC, Erickson BK, Huang T, Tsai TH, Vitek O, Reichelt M, Senbabaoglu Y, Mckenzie B, Rohde JR, Dikic I, Kirkpatrick DS, Murthy A
Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response.
Elife
2021.
10
Link
Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, et al.
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
ACS Cent Sci
2021.
7
(5)
792-802
Link
Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, Kaulich M
Minimized combinatorial CRISPR screens identify genetic interactions in autophagy.
Nucleic Acids Res
2021.
49
(10)
5684-5704
Link
Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C, Dikic I
SIK2 orchestrates actin-dependent host response upon infection.
Proc Natl Acad Sci U S A
2021.
118
(19)
Link
Kannt A, Đikić I
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation.
Cell Chem Biol
2021.
28
(7)
1014-1031
Link
Gubas A, Dikic I
A guide to the regulation of selective autophagy receptors.
FEBS J
2021.
Link
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
2021.
17
(1)
1-382
Link
Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS, McEwan DG
The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.
FEBS Lett
2021.
595
(7)
864-880
Link
Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I, Tan MW
Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii.
Sci Rep
2021.
11
(1)
618
Link
Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, et al.
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Int J Mol Sci
2021.
22
(2)
Link
Shin D, Bhattacharya A, Cheng YL, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G, Dikic I
Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection.
Elife
2020.
9
Link
Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S
Correction: Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells.
J Biol Chem
2020.
295
(43)
14792
Link
Kim RQ, Misra M, Gonzalez A, Tomašković I, Shin D, Schindelin H, Filippov DV, Ovaa H, Đikić I, van der Heden van Noort GJ
Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection.
Chemistry
2021.
27
(7)
2506-2512
Link
Waidmann O, Pleli T, Weigert A, Imelmann E, Kakoschky B, Schmithals C, Döring C, Frank M, Longerich T, Köberle V, Hansmann ML, Brüne B, Zeuzem S, Piiper A, Dikic I
Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
Sci Rep
2020.
10
(1)
16264
Link
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Nature
2020.
587
(7835)
657-662
Link
Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I
Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol
2020.
27
(11)
1441-1451.e7
Link
Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh LG, Huebner AK, Cesana M, Bonn F, Polishchuk E, Hübner CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
EMBO J
2020.
39
(17)
e105696
Link
Tiku V, Tan MW, Dikic I
Mitochondrial Functions in Infection and Immunity: (Trends in Cell Biology 30, 263-275, 2020).
Trends Cell Biol
2020.
30
(9)
748
Link
Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codée JDC, Filippov DV, van der Heden van Noort GJ
Synthesis of Stable NAD Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC.
Chembiochem
2020.
21
(20)
2903-2907
Link
Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I, Ernst A
Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine.
Front Cell Dev Biol
2020.
8
208
Link
Tiku V, Tan MW, Dikic I
Mitochondrial Functions in Infection and Immunity.
Trends Cell Biol
2020.
30
(4)
263-275
Link
Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J, Dikic I
Wss1 Promotes Replication Stress Tolerance by Degrading Histones.
Cell Rep
2020.
30
(9)
3117-3126.e4
Link
Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I, Heilemann M
Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells.
Sci Signal
2020.
13
(614)
Link
Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I
Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB.
Mol Cell
2020.
77
(1)
164-179.e6
Link
Pohl C, Dikic I
Cellular quality control by the ubiquitin-proteasome system and autophagy.
Science
2019.
366
(6467)
818-822
Link
Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I
TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease.
EMBO Rep
2020.
21
(1)
e48317
Link
Hübner CA, Dikic I
ER-phagy and human diseases.
Cell Death Differ
2020.
27
(3)
833-842
Link
Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation.
Nature
2019.
572
(7769)
382-386
Link
Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I
CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.
Nat Microbiol
2019.
4
(9)
1516-1531
Link
Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S
Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J Mol Biol
2019.
431
(17)
3146-3156
Link
Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G
Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy.
Nat Commun
2019.
10
(1)
2370
Link
Mukherjee R, Dikic I
NIPSNAP Beacons in Mitophagy.
Dev Cell
2019.
49
(4)
503-505
Link
Misra M, Dikic I
RNA binding to p62 impacts selective autophagy.
Cell Res
2019.
29
(7)
512-513
Link
Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Autophagy
2020.
16
(2)
256-270
Link
Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M
Deubiquitinase USP10 regulates Notch signaling in the endothelium.
Science
2019.
364
(6436)
188-193
Link
Tiku V, Dikic I
Autophagy without conjugation.
Nat Struct Mol Biol
2019.
26
(4)
249-250
Link
Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D
Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.
Cancers (Basel)
2019.
11
(3)
Link
Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome.
Elife
2019.
8
Link
Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L
Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.
Kidney Int
2019.
95
(3)
540-562
Link
van Wijk SJ, Fulda S, Dikic I, Heilemann M
Visualizing ubiquitination in mammalian cells.
EMBO Rep
2019.
20
(2)
Link
Juretschke T, Beli P, Dikic I
Quantitative Phosphoproteomics of Selective Autophagy Receptors.
Methods Mol Biol
2019.
1880
691-701
Link
Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M
The next decade of metabolism.
Nat Metab
2019.
1
(1)
2-4
Link
Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C
A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.
EMBO J
2019.
38
(2)
Link
Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG
Structural and functional analysis of the GABARAP interaction motif (GIM).
EMBO Rep
2018.
19
(12)
Link
Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH
Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.
Blood
2019.
133
(2)
168-179
Link
Dikic I
Open questions: why should we care about ER-phagy and ER remodelling?
BMC Biol
2018.
16
(1)
131
Link
Herhaus L, Dikic I
Dimerization quality control via ubiquitylation.
Science
2018.
362
(6411)
151-152
Link
Stolz A, Dikic I
Elusive mitochondrial connection to inflammation uncovered.
Nature
2018.
561
(7722)
185-186
Link
Grumati P, Dikic I, Stolz A
ER-phagy at a glance.
J Cell Sci
2018.
131
(17)
Link
Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I
Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination.
Nature
2018.
557
(7707)
734-738
Link
Münch C, Dikic I
Publisher Correction: Hitchhiking on selective autophagy.
Nat Cell Biol
2018.
20
(8)
990
Link
Dikic I, Elazar Z
Mechanism and medical implications of mammalian autophagy.
Nat Rev Mol Cell Biol
2018.
19
(6)
349-364
Link
Herhaus L, Dikic I
Ubiquitin-induced phase separation of p62/SQSTM1.
Cell Res
2018.
28
(4)
389-390
Link
Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D
BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells.
Neoplasia
2018.
20
(3)
263-279
Link
Münch C, Dikic I
Hitchhiking on selective autophagy.
Nat Cell Biol
2018.
20
(2)
122-124
Link
Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V
Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains.
Structure
2018.
26
(2)
249-258.e4
Link
Ramadan K, Dikic I
Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response.
Front Genet
2017.
8
188
Link
Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV
A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.
Angew Chem Int Ed Engl
2018.
57
(6)
1659-1662
Link
Stolz A, Dikic I
Heterotypic Ubiquitin Chains: Seeing is Believing.
Trends Cell Biol
2018.
28
(1)
1-3
Link
Grumati P, Dikic I
Ubiquitin signaling and autophagy.
J Biol Chem
2018.
293
(15)
5404-5413
Link
Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N
Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring.
Proc Natl Acad Sci U S A
2017.
114
(49)
13042-13047
Link
Herhaus L, Dikic I
Regulation of Salmonella-host cell interactions via the ubiquitin system.
Int J Med Microbiol
2018.
308
(1)
176-184
Link
Amstein L, Ackermann J, Scheidel J, Fulda S, Dikic I, Koch I
Manatee invariants reveal functional pathways in signaling networks.
BMC Syst Biol
2017.
11
(1)
72
Link
Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG
Structural and functional analysis of the GABARAP interaction motif (GIM).
EMBO Rep
2017.
18
(8)
1382-1396
Link
Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy.
Elife
2017.
6
Link
Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, et al.
Molecular definitions of autophagy and related processes.
EMBO J
2017.
36
(13)
1811-1836
Link
Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Mol Cell
2017.
66
(4)
517-532.e9
Link
van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.
Nat Microbiol
2017.
2
17066
Link
Dikic I
Proteasomal and Autophagic Degradation Systems.
Annu Rev Biochem
2017.
86
193-224
Link
Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I
Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins.
Sci Rep
2017.
7
(1)
1131
Link
Šprung M, Dikic I, Novak I
Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy.
Methods Mol Biol
2018.
1759
105-110
Link
Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R, et al.
Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.
Cell Res
2017.
27
(5)
657-674
Link
Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
Elife
2017.
6
Link
Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I
Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.
Nat Commun
2017.
8
14004
Link
Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR
IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
J Exp Med
2017.
214
(2)
423-437
Link
Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I
Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.
EMBO J
2017.
36
(4)
549-564
Link
Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I
Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.
Cell
2016.
167
(6)
1636-1649.e13
Link
Tooze SA, Dikic I
Autophagy Captures the Nobel Prize.
Cell
2016.
167
(6)
1433-1435
Link
Scheidel J, Amstein L, Ackermann J, Dikic I, Koch I
In Silico Knockout Studies of Xenophagic Capturing of Salmonella.
PLoS Comput Biol
2016.
12
(12)
e1005200
Link
Seczynska M, Dikic I
Removing the waste bags: how p97 drives autophagy of lysosomes.
EMBO J
2017.
36
(2)
129-131
Link
Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I
SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.
Elife
2016.
5
Link
Hoeller D, Dikic I
How the proteasome is degraded.
Proc Natl Acad Sci U S A
2016.
113
(47)
13266-13268
Link
Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M
CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.
Diabetes
2016.
65
(12)
3667-3679
Link
Weishaupt JH, Hyman T, Dikic I
Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Trends Mol Med
2016.
22
(9)
769-783
Link
Fiskin E, Bionda T, Dikic I, Behrends C
Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection.
Mol Cell
2016.
62
(6)
967-981
Link
Bhogaraju S, Dikic I
Cell biology: Ubiquitination without E1 and E2 enzymes.
Nature
2016.
533
(7601)
43-4
Link
Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M
A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
FEBS J
2016.
283
(11)
2004-17
Link
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
Proc Natl Acad Sci U S A
2016.
113
(15)
4039-44
Link
Baccarini M, Dikic I
Editorial overview: Cell regulation.
Curr Opin Cell Biol
2016.
39
iv-vi
Link
Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, Schaefer L
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
Am J Pathol
2016.
186
(5)
1206-20
Link
Maculins T, Fiskin E, Bhogaraju S, Dikic I
Bacteria-host relationship: ubiquitin ligases as weapons of invasion.
Cell Res
2016.
26
(4)
499-510
Link
Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M
Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Oncotarget
2016.
7
(15)
20016-32
Link
Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V
Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation.
J Biol Chem
2016.
291
(17)
9025-41
Link
Rajalingam K, Dikic I
SnapShot: Expanding the Ubiquitin Code.
Cell
2016.
164
(5)
1074-1074.e1
Link
Akutsu M, Dikic I, Bremm A
Ubiquitin chain diversity at a glance.
J Cell Sci
2016.
129
(5)
875-80
Link
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, et al.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy
2016.
12
(1)
1-222
Link
Gomes LC, Odedra D, Dikic I, Pohl C
Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans.
Autophagy
2016.
12
(3)
529-46
Link
Kern A, Dikic I, Behl C
The integration of autophagy and cellular trafficking pathways via RAB GAPs.
Autophagy
2015.
11
(12)
2393-7
Link
Khaminets A, Behl C, Dikic I
Ubiquitin-Dependent And Independent Signals In Selective Autophagy.
Trends Cell Biol
2016.
26
(1)
6-16
Link
Herhaus L, Dikic I
Expanding the ubiquitin code through post-translational modification.
EMBO Rep
2015.
16
(9)
1071-83
Link
Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S
Binding of SGTA to Rpn13 selectively modulates protein quality control.
J Cell Sci
2015.
128
(17)
3187-96
Link
Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I
Regulation of endoplasmic reticulum turnover by selective autophagy.
Nature
2015.
522
(7556)
354-8
Link
McEwan DG, Dikic I
PLEKHM1: Adapting to life at the lysosome.
Autophagy
2015.
11
(4)
720-2
Link
Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, et al.
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
Nat Neurosci
2015.
18
(5)
631-6
Link
McEwan DG, Dikic I
Cullins keep autophagy under control.
Dev Cell
2014.
31
(6)
675-6
Link
Stolz A, Dikic I
PINK1-PARKIN interplay: down to ubiquitin phosphorylation.
Mol Cell
2014.
56
(3)
341-342
Link
McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I
PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
Cell Host Microbe
2015.
17
(1)
58-71
Link
McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I
PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
Mol Cell
2015.
57
(1)
39-54
Link
Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy.
Autophagy
2014.
10
(12)
2297-309
Link
Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.
Elife
2014.
3
Link
Popovic D, Vucic D, Dikic I
Ubiquitination in disease pathogenesis and treatment.
Nat Med
2014.
20
(11)
1242-53
Link
Dikic I, Bremm A
DUBs counteract parkin for efficient mitophagy.
EMBO J
2014.
33
(21)
2442-3
Link
Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, et al.
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
Nat Genet
2014.
46
(11)
1239-44
Link
Bhogaraju S, Dikic I
A peek into the atomic details of thalidomide's clinical effects.
Nat Struct Mol Biol
2014.
21
(9)
739-40
Link
Stolz A, Ernst A, Dikic I
Cargo recognition and trafficking in selective autophagy.
Nat Cell Biol
2014.
16
(6)
495-501
Link
López-Mosqueda J, Dikic I
Deciphering functions of branched ubiquitin chains.
Cell
2014.
157
(4)
767-9
Link
Gomes LC, Dikic I
Autophagy in antimicrobial immunity.
Mol Cell
2014.
54
(2)
224-33
Link
Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Mol Cell
2014.
54
(3)
349-61
Link
Grumati P, Dikic I
Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling.
Cancer Discov
2014.
4
(4)
394-6
Link
Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V
Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification.
Chem Biol
2014.
21
(4)
552-562
Link
Popovic D, Dikic I
TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy.
EMBO Rep
2014.
15
(4)
392-401
Link
Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H
The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente.
EMBO Rep
2014.
15
(1)
7-11
Link
Piper RC, Dikic I, Lukacs GL
Ubiquitin-dependent sorting in endocytosis.
Cold Spring Harb Perspect Biol
2014.
6
(1)
Link
Wild P, McEwan DG, Dikic I
The LC3 interactome at a glance.
J Cell Sci
2014.
127
(Pt 1)
3-9
Link
Putyrski M, Dikic I
Breaking the limits of artificial ubiquitination.
Proc Natl Acad Sci U S A
2013.
110
(44)
17606-7
Link
Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K
Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature
2013.
503
(7476)
422-426
Link
van Wijk SJ, Fiškin E, Dikic I
Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors.
Nat Protoc
2013.
8
(7)
1449-58
Link
Rogov VV, Suzuki H, Fiskin E, Wild P, Kniss A, Rozenknop A, Kato R, Kawasaki M, McEwan DG, Löhr F, Güntert P, Dikic I, Wakatsuki S, Dötsch V
Structural basis for phosphorylation-triggered autophagic clearance of Salmonella.
Biochem J
2013.
454
(3)
459-66
Link
Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM
The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.
Dev Cell
2013.
25
(1)
15-28
Link
Olma MH, Dikic I
Cullins getting undressed by the protein exchange factor Cand1.
Cell
2013.
153
(1)
14-6
Link
Fiškin E, Dikic I
Parkin promotes cell survival via linear ubiquitination.
EMBO J
2013.
32
(8)
1072-4
Link
Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing.
Nat Methods
2013.
10
(4)
361-5
Link
Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR
Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis.
J Biol Chem
2013.
288
(2)
1099-113
Link
Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I
Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates.
J Cell Sci
2013.
126
(Pt 2)
580-92
Link
Verhelst K, Carpentier I, Kreike M, Meloni L, Verstrepen L, Kensche T, Dikic I, Beyaert R
A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7.
EMBO J
2012.
31
(19)
3845-55
Link
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, et al.
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy
2012.
8
(4)
445-544
Link
Rizvi H, Paterson JC, Tedoldi S, Ramsay A, Calaminici M, Natkunam Y, Lonardi S, Tan SY, Campbell L, Hansmann ML, Jones D, Dikic I, Shaw AS, Pileri SA, Stein H, Mason DY, Facchetti F, Marafioti T
Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue.
Pathologica
2012.
104
(2)
56-64
Link
Pohl C, Dikic I
Fighting mycobacteria through ISGylation.
EMBO Rep
2012.
13
(10)
872-3
Link
Belgnaoui SM, Paz S, Samuel S, Goulet ML, Sun Q, Kikkert M, Iwai K, Dikic I, Hiscott J, Lin R
Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.
Cell Host Microbe
2012.
12
(2)
211-22
Link
van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I
Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells.
Mol Cell
2012.
47
(5)
797-809
Link
Fulda S, Rajalingam K, Dikic I
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications.
EMBO Mol Med
2012.
4
(7)
545-56
Link
Shaid S, Brandts CH, Serve H, Dikic I
Ubiquitination and selective autophagy.
Cell Death Differ
2013.
20
(1)
21-30
Link
Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I
Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
J Biol Chem
2012.
287
(28)
23626-34
Link
Rahighi S, Dikic I
Selectivity of the ubiquitin-binding modules.
FEBS Lett
2012.
586
(17)
2705-10
Link
Stieglitz B, Haire LF, Dikic I, Rittinger K
Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.
J Biol Chem
2012.
287
(25)
20823-9
Link
Husnjak K, Dikic I
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions.
Annu Rev Biochem
2012.
81
291-322
Link
Rogov VV, Rozenknop A, Rogova NY, Löhr F, Tikole S, Jaravine V, Güntert P, Dikic I, Dötsch V
A universal expression tag for structural and functional studies of proteins.
Chembiochem
2012.
13
(7)
959-63
Link
Walczak H, Iwai K, Dikic I
Generation and physiological roles of linear ubiquitin chains.
BMC Biol
2012.
10
23
Link
Dikic I, Robertson M
Ubiquitin ligases and beyond.
BMC Biol
2012.
10
22
Link
Dikic I
Ivan Dikic was trained as a medical doctor at the University of Zagreb, Croatia.
Curr Biol
2012.
22
(3)
R76-7
Link
Haglund K, Dikic I
The role of ubiquitylation in receptor endocytosis and endosomal sorting.
J Cell Sci
2012.
125
(Pt 2)
265-75
Link
Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I
Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
Mol Cell Biol
2012.
32
(9)
1733-44
Link
Dikic I, Daly RJ
Signalling through the grapevine.
EMBO Rep
2012.
13
(3)
178-80
Link
van Wijk SJ, Bienko M, Dikic I
Role of UbL family modifiers and their binding proteins in cell signaling.
Methods Mol Biol
2012.
832
163-71
Link
Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S
Structure of a compact conformation of linear diubiquitin.
Acta Crystallogr D Biol Crystallogr
2012.
68
(Pt 2)
102-8
Link
Pareja F, Ferraro DA, Rubin C, Cohen-Dvashi H, Zhang F, Aulmann S, Ben-Chetrit N, Pines G, Navon R, Crosetto N, Köstler W, Carvalho S, Lavi S, Schmitt F, Dikic I, Yakhini Z, Sinn P, Mills GB, Yarden Y
Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.
Oncogene
2012.
31
(43)
4599-608
Link
Sandilands E, Serrels B, McEwan DG, Morton JP, Macagno JP, McLeod K, Stevens C, Brunton VG, Langdon WY, Vidal M, Sansom OJ, Dikic I, Wilkinson S, Frame MC
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.
Nat Cell Biol
2011.
14
(1)
51-60
Link
van Wijk SJ, Müller S, Dikic I
Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair.
Genes Dev
2011.
25
(17)
1763-9
Link
Rahighi S, Dikic I
Conformational flexibility and rotation of the RING domain in activation of cullin-RING ligases.
Nat Struct Mol Biol
2011.
18
(8)
863-5
Link
Rajalingam K, Dikic I
Healthy ageing through regulated proteostasis.
EMBO J
2011.
30
(15)
2983-5
Link
Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V
Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1.
J Mol Biol
2011.
410
(3)
477-87
Link
Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
Science
2011.
333
(6039)
228-33
Link
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Nature
2011.
471
(7340)
637-41
Link
Grabbe C, Husnjak K, Dikic I
The spatial and temporal organization of ubiquitin networks.
Nat Rev Mol Cell Biol
2011.
12
(5)
295-307
Link
Mendl N, Occhipinti A, Müller M, Wild P, Dikic I, Reichert AS
Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2.
J Cell Sci
2011.
124
(Pt 8)
1339-50
Link
McEwan DG, Dikic I
The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation.
Trends Cell Biol
2011.
21
(4)
195-201
Link
Hoeller D, Dikic I
Regulation of ubiquitin receptors by coupled monoubiquitination.
Subcell Biochem
2010.
54
31-40
Link
Novak I, Dikic I
Autophagy receptors in developmental clearance of mitochondria.
Autophagy
2011.
7
(3)
301-3
Link
Ikeda F, Rahighi S, Wakatsuki S, Dikic I
Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation.
Adv Exp Med Biol
2011.
691
107-14
Link
Ikeda F, Crosetto N, Dikic I
What determines the specificity and outcomes of ubiquitin signaling?
Cell
2010.
143
(5)
677-81
Link
Kirkin V, Dikic I
Ubiquitin networks in cancer.
Curr Opin Genet Dev
2011.
21
(1)
21-8
Link
Suzuki N, Hiraki M, Yamada Y, Matsugaki N, Igarashi N, Kato R, Dikic I, Drew D, Iwata S, Wakatsuki S, Kawasaki M
Crystallization of small proteins assisted by green fluorescent protein.
Acta Crystallogr D Biol Crystallogr
2010.
66
(Pt 10)
1059-66
Link
Bethani I, Skånland SS, Dikic I, Acker-Palmer A
Spatial organization of transmembrane receptor signalling.
EMBO J
2010.
29
(16)
2677-88
Link
Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, et al.
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
EMBO J
2010.
29
(14)
2421-32
Link
Deribe YL, Pawson T, Dikic I
Post-translational modifications in signal integration.
Nat Struct Mol Biol
2010.
17
(6)
666-72
Link
Dikic I, Schmidt MHH
Notch: Implications of endogenous inhibitors for therapy.
Bioessays
2010.
32
(6)
481-487
Link
McEwan DG, Dikic I
Not all autophagy membranes are created equal.
Cell
2010.
141
(4)
564-6
Link
Haglund K, Nezis IP, Lemus D, Grabbe C, Wesche J, Liestøl K, Dikic I, Palmer R, Stenmark H
Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster.
Curr Biol
2010.
20
(10)
944-50
Link
Dikic I, Johansen T, Kirkin V
Selective autophagy in cancer development and therapy.
Cancer Res
2010.
70
(9)
3431-4
Link
Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Proc Natl Acad Sci U S A
2010.
107
(14)
6459-64
Link
Bomar MG, D'Souza S, Bienko M, Dikic I, Walker GC, Zhou P
Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1.
Mol Cell
2010.
37
(3)
408-17
Link
Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I
Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.
Mol Cell
2010.
37
(3)
396-407
Link
Wild P, Dikic I
Mitochondria get a Parkin' ticket.
Nat Cell Biol
2010.
12
(2)
104-6
Link
Nagy V, Dikic I
Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity.
Biol Chem
.
391
(2-3)
163-169
Link
Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MHH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.
Sci Signal
2009.
2
(102)
ra84
Link
Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichert AS, Terzic J, Dötsch V, Ney PA, Dikic I
Nix is a selective autophagy receptor for mitochondrial clearance.
EMBO Rep
2010.
11
(1)
45-51
Link
Dikic I, Dötsch V
Ubiquitin linkages make a difference.
Nat Struct Mol Biol
2009.
16
(12)
1209-10
Link
Dikic I, Wakatsuki S, Walters KJ
Ubiquitin-binding domains - from structures to functions.
Nat Rev Mol Cell Biol
2009.
10
(10)
659-71
Link
Lappe-Siefke C, Loebrich S, Hevers W, Waidmann OB, Schweizer M, Fehr S, Fritschy JM, Dikic I, Eilers J, Wilson SM, Kneussel M
The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.
PLoS Genet
2009.
5
(9)
e1000631
Link
Schmidt MHH, Bicker F, Nikolic I, Meister J, Babuke T, Picuric S, Müller-Esterl W, Plate KH, Dikic I
Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.
Nat Cell Biol
2009.
11
(7)
873-80
Link
Lamark T, Kirkin V, Dikic I, Johansen T
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets.
Cell Cycle
2009.
8
(13)
1986-90
Link
Kirkin V, McEwan DG, Novak I, Dikic I
A role for ubiquitin in selective autophagy.
Mol Cell
2009.
34
(3)
259-69
Link
Kirkin V, Lamark T, Johansen T, Dikic I
NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.
Autophagy
2009.
5
(5)
732-3
Link
Dikic I
Journal club. A new ubiquitin chain, a new signal.
Nat Rev Mol Cell Biol
2009.
10
(5)
306
Link
Hoeller D, Dikic I
Targeting the ubiquitin system in cancer therapy.
Nature
2009.
458
(7237)
438-44
Link
Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.
Cell
2009.
136
(6)
1098-109
Link
Grabbe C, Dikic I
Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins.
Chem Rev
2009.
109
(4)
1481-94
Link
Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Mol Cell
2009.
33
(4)
505-16
Link
Sabbioneda S, Green CM, Bienko M, Kannouche P, Dikic I, Lehmann AR
Ubiquitin-binding motif of human DNA polymerase eta is required for correct localization.
Proc Natl Acad Sci U S A
2009.
106
(8)
E20; author reply E21
Link
Scharner D, Rössig L, Carmona G, Chavakis E, Urbich C, Fischer A, Kang TB, Wallach D, Chiang YJ, Deribe YL, Dikic I, Zeiher AM, Dimmeler S
Caspase-8 is involved in neovascularization-promoting progenitor cell functions.
Arterioscler Thromb Vasc Biol
2009.
29
(4)
571-8
Link
Rajalingam K, Dikic I
Inhibitors of apoptosis catch ubiquitin.
Biochem J
2009.
417
(1)
e1-3
Link
Grabbe C, Dikic I
Cell biology. Going global on ubiquitin.
Science
2008.
322
(5903)
872-3
Link
Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I
Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.
J Biol Chem
2008.
283
(50)
35173-85
Link
Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J
Reply to "The binding stoichiometry of CIN85 SH3 domain A and Cbl-b".
Nat Struct Mol Biol
2008.
15
(9)
891-2
Link
Nonis D, Schmidt MHH, van de Loo S, Eich F, Dikic I, Nowock J, Auburger G
Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
Cell Signal
2008.
20
(10)
1725-39
Link
Ikeda F, Dikic I
Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series.
EMBO Rep
2008.
9
(6)
536-42
Link
Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
Nature
2008.
453
(7194)
548-52
Link
Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I
Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Nature
2008.
453
(7194)
481-8
Link
Schmidt-Glenewinkel H, Vacheva I, Hoeller D, Dikic I, Eils R
An ultrasensitive sorting mechanism for EGF receptor endocytosis.
BMC Syst Biol
2008.
2
32
Link
Zagrovic B, Dikic I
Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe.
Nat Rev Mol Cell Biol
2008.
9
(4)
333-6
Link
Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.
EMBO J
2008.
27
(4)
629-41
Link
Marafioti T, Paterson JC, Ballabio E, Reichard KK, Tedoldi S, Hollowood K, Dictor M, Hansmann ML, Pileri SA, Dyer MJ, Sozzani S, Dikic I, Shaw AS, Petrella T, Stein H, Isaacson PG, Facchetti F, Mason DY
Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
Blood
2008.
111
(7)
3778-92
Link
Bloor S, Ryzhakov G, Wagner S, Butler PJ, Smith DL, Krumbach R, Dikic I, Randow F
Signal processing by its coil zipper domain activates IKK gamma.
Proc Natl Acad Sci U S A
2008.
105
(4)
1279-84
Link
Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R
Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.
Oncogene
2008.
27
(26)
3739-45
Link
Guo C, Tang TS, Bienko M, Dikic I, Friedberg EC
Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance.
J Biol Chem
2008.
283
(8)
4658-64
Link
Terzic J, Marinovic-Terzic I, Ikeda F, Dikic I
Ubiquitin signals in the NF-kappaB pathway.
Biochem Soc Trans
2007.
35
(Pt 5)
942-5
Link
Raguz J, Wagner S, Dikic I, Hoeller D
Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases.
FEBS Lett
2007.
581
(24)
4767-72
Link
Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
EMBO J
2007.
26
(14)
3451-62
Link
Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I
E3-independent monoubiquitination of ubiquitin-binding proteins.
Mol Cell
2007.
26
(6)
891-8
Link
Dikic I, Schmidt MHH
Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport.
Eur J Cell Biol
2007.
86
(9)
505-12
Link
Sargin B, Choudhary C, Crosetto N, Schmidt MHH, Grundler R, Rensinghoff M, Thiessen C, Tickenbrock L, Schwäble J, Brandts C, August B, Koschmieder S, Bandi SR, Duyster J, Berdel WE, Müller-Tidow C, Dikic I, Serve H
Flt3-dependent transformation by inactivating c-Cbl mutations in AML.
Blood
2007.
110
(3)
1004-12
Link
Kirkin V, Dikic I
Role of ubiquitin- and Ubl-binding proteins in cell signaling.
Curr Opin Cell Biol
2007.
19
(2)
199-205
Link
Parker JL, Bielen AB, Dikic I, Ulrich HD
Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae.
Nucleic Acids Res
2007.
35
(3)
881-9
Link
Tossidou I, Kardinal C, Peters I, Kriz W, Shaw A, Dikic I, Tkachuk S, Dumler I, Haller H, Schiffer M
CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes.
J Biol Chem
2007.
282
(10)
7457-64
Link
Crosetto N, Bienko M, Dikic I
Ubiquitin hubs in oncogenic networks.
Mol Cancer Res
2006.
4
(12)
899-904
Link
Schmidt MHH, Dikic I
Ubiquitin and NEDD8: brothers in arms.
Sci STKE
2006.
2006
(362)
.pe50
Link
Dikic I, Crosetto N, Calatroni S, Bernasconi P
Targeting ubiquitin in cancers.
Eur J Cancer
2006.
42
(18)
3095-102
Link
Moncalián G, Cárdenes N, Deribe YL, Spínola-Amilibia M, Dikic I, Bravo J
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.
J Biol Chem
2006.
281
(50)
38845-53
Link
Hoeller D, Hecker CM, Dikic I
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis.
Nat Rev Cancer
2006.
6
(10)
776-88
Link
Guo C, Tang TS, Bienko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage.
Mol Cell Biol
2006.
26
(23)
8892-900
Link
Husnjak K, Dikic I
EGFR trafficking: parkin' in a jam.
Nat Cell Biol
2006.
8
(8)
787-8
Link
Seet BT, Dikic I, Zhou MM, Pawson T
Reading protein modifications with interaction domains.
Nat Rev Mol Cell Biol
2006.
7
(7)
473-83
Link
Schmidt MHH, Dikic I
Assays to monitor degradation of the EGF receptor.
Methods Mol Biol
2006.
327
131-8
Link
Ikeda F, Dikic I
CYLD in ubiquitin signaling and tumor pathogenesis.
Cell
2006.
125
(4)
643-5
Link
Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I
Specification of SUMO1- and SUMO2-interacting motifs.
J Biol Chem
2006.
281
(23)
16117-27
Link
Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I
Regulation of ubiquitin-binding proteins by monoubiquitination.
Nat Cell Biol
2006.
8
(2)
163-9
Link
Schmidt MHH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.
Oncogene
2006.
25
(21)
3071-8
Link
Katic M, Bosnjak B, Gall-Troselj K, Dikic I, Pavelic K
A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro.
Front Biosci
2006.
11
1722-32
Link
Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science
2005.
310
(5755)
1821-4
Link
Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P
CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
Biochem Biophys Res Commun
2005.
338
(2)
808-14
Link
Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J
Cbl promotes clustering of endocytic adaptor proteins.
Nat Struct Mol Biol
2005.
12
(11)
972-9
Link
Schmidt MHH, Dikic I
The Cbl interactome and its functions.
Nat Rev Mol Cell Biol
2005.
6
(12)
907-18
Link
Molfetta R, Belleudi F, Peruzzi G, Morrone S, Leone L, Dikic I, Piccoli M, Frati L, Torrisi MR, Santoni A, Paolini R
CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function.
J Immunol
2005.
175
(7)
4208-16
Link
Haglund K, Dikic I
Ubiquitylation and cell signaling.
EMBO J
2005.
24
(19)
3353-9
Link
Eckerdt F, Yuan J, Saxena K, Martin B, Kappel S, Lindenau C, Kramer A, Naumann S, Daum S, Fischer G, Dikic I, Kaufmann M, Strebhardt K
Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells.
J Biol Chem
2005.
280
(44)
36575-83
Link
Sulić S, Panić L, Dikić I, Volarević S
Deregulation of cell growth and malignant transformation.
Croat Med J
2005.
46
(4)
622-38
Link
Haglund K, Schmidt MHH, Wong ES, Guy GR, Dikic I
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
EMBO Rep
2005.
6
(7)
635-41
Link
Crosetto N, Tikkanen R, Dikic I
Oncogenic breakdowns in endocytic adaptor proteins.
FEBS Lett
2005.
579
(15)
3231-8
Link
Hoeller D, Volarevic S, Dikic I
Compartmentalization of growth factor receptor signalling.
Curr Opin Cell Biol
2005.
17
(2)
107-11
Link
Shimokawa N, Dikic I, Sugama S, Koibuchi N
Molecular responses to acidosis of central chemosensitive neurons in brain.
Cell Signal
2005.
17
(7)
799-808
Link
Banno Y, Ohguchi K, Matsumoto N, Koda M, Ueda M, Hara A, Dikic I, Nozawa Y
Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells.
J Biol Chem
2005.
280
(16)
16319-24
Link
Schmidt MHH, Dikic I, Bögler O
Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities.
J Biol Chem
2005.
280
(5)
3414-25
Link
Schmidt MHH, Hoeller D, Yu J, Furnari FB, Cavenee WK, Dikic I, Bögler O
Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.
Mol Cell Biol
2004.
24
(20)
8981-93
Link
Szymkiewicz I, Shupliakov O, Dikic I
Cargo- and compartment-selective endocytic scaffold proteins.
Biochem J
2004.
383
(Pt 1)
1-11
Link
Dikic I
ALIX-ing phospholipids with endosome biogenesis.
Bioessays
2004.
26
(6)
604-7
Link
Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
J Biol Chem
2004.
279
(31)
32786-95
Link
Szymkiewicz I, Destaing O, Jurdic P, Dikic I
SH3P2 in complex with Cbl and Src.
FEBS Lett
2004.
565
(1-3)
33-8
Link
Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.
J Cell Sci
2004.
117
(Pt 12)
2557-68
Link
Shimokawa N, Qiu CH, Seki T, Dikic I, Koibuchi N
Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression.
Cell Signal
2004.
16
(6)
723-9
Link
Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA, Dikic I
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.
Mol Biol Cell
2004.
15
(7)
3155-66
Link
Höller D, Dikic I
Receptor endocytosis via ubiquitin-dependent and -independent pathways.
Biochem Pharmacol
2004.
67
(6)
1013-7
Link
Dikic I
Mechanisms controlling EGF receptor endocytosis and degradation.
Biochem Soc Trans
2003.
31
(Pt 6)
1178-81
Link
Haglund K, Di Fiore PP, Dikic I
Distinct monoubiquitin signals in receptor endocytosis.
Trends Biochem Sci
2003.
28
(11)
598-603
Link
Kowanetz K, Terzic J, Dikic I
Dab2 links CIN85 with clathrin-mediated receptor internalization.
FEBS Lett
2003.
554
(1-2)
81-7
Link
Dikic I, Szymkiewicz I, Soubeyran P
Cbl signaling networks in the regulation of cell function.
Cell Mol Life Sci
2003.
60
(9)
1805-27
Link
Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I
Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.
J Biol Chem
2003.
278
(41)
39735-46
Link
Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore PP, Dikic I
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation.
Nat Cell Biol
2003.
5
(5)
461-6
Link
Dikic I, Giordano S
Negative receptor signalling.
Curr Opin Cell Biol
2003.
15
(2)
128-35
Link
Piiper A, Lutz MP, Cramer H, Elez R, Kronenberger B, Dikic I, Müller-Esterl W, Zeuzem S
Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor.
Biochem Biophys Res Commun
2003.
301
(4)
848-54
Link
Soubeyran P, Barac A, Szymkiewicz I, Dikic I
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
Biochem J
2003.
370
(Pt 1)
29-34
Link
Shimokawa N, Okada J, Haglund K, Dikic I, Koibuchi N, Miura M
Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain.
J Neurosci
2002.
22
(21)
9160-5
Link
Dikic I
CIN85/CMS family of adaptor molecules.
FEBS Lett
2002.
529
(1)
110-5
Link
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.
Proc Natl Acad Sci U S A
2002.
99
(19)
12191-6
Link
Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S
Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells.
J Biol Chem
2002.
277
(46)
43623-30
Link
Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.
J Biol Chem
2002.
277
(42)
39666-72
Link
Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.
Nature
2002.
416
(6877)
183-7
Link
Sajan MP, Bandyopadhyay G, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV
Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.
Biochem J
2002.
362
(Pt 3)
665-74
Link
Picascia A, Stanzione R, Chieffi P, Kisslinger A, Dikic I, Tramontano D
Proline-rich tyrosine kinase 2 regulates proliferation and differentiation of prostate cells.
Mol Cell Endocrinol
2002.
186
(1)
81-7
Link
Pizard A, Blaukat A, Michineau S, Dikic I, Müller-Esterl W, Alhenc-Gelas F, Rajerison RM
Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy.
Biochemistry
2001.
40
(51)
15743-51
Link
Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I
Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.
J Biol Chem
2001.
276
(44)
40431-40
Link
Soubeyran P, Haglund K, Garcia S, Barth BU, Iovanna J, Dikic I
Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells.
Oncogene
2001.
20
(31)
4180-7
Link
Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV
Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.
J Biol Chem
2001.
276
(38)
35537-45
Link
Pavelić K, Hadzija M, Bedrica L, Pavelić J, Dikić I, Katić M, Kralj M, Bosnar MH, Kapitanović S, Poljak-Blazi M, Krizanac S, Stojković R, Jurin M, Subotić B, Colić M
Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.
J Mol Med (Berl)
2001.
78
(12)
708-20
Link
Blaukat A, Dikic I
Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway.
Biol Chem
2001.
382
(1)
135-9
Link
Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Burke TR, Quon MJ, Reed BC, Dikic I, Noel LE, Newgard CB, Farese R
Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter.
J Biol Chem
2000.
275
(52)
40817-26
Link
Ivankovic-Dikic I, Grönroos E, Blaukat A, Barth BU, Dikic I
Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins.
Nat Cell Biol
2000.
2
(9)
574-81
Link
Blaukat A, Barac A, Cross MJ, Offermanns S, Dikic I
G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals.
Mol Cell Biol
2000.
20
(18)
6837-48
Link
Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2.
J Biol Chem
2000.
275
(38)
29338-47
Link
Soubeyran P, André F, Lissitzky JC, Mallo GV, Moucadel V, Roccabianca M, Rechreche H, Marvaldi J, Dikic I, Dagorn JC, Iovanna JL
Cdx1 promotes differentiation in a rat intestinal epithelial cell line.
Gastroenterology
1999.
117
(6)
1326-38
Link
Dikić I, Pavelić K
Dubrovnik Conference on Signal Transduction: an opportunity for education of young scientists.
Acta Med Croatica
1999.
53
(1)
1-4
Link
Dikic I, Blaukat A
Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling.
Cell Biochem Biophys
1999.
30
(3)
369-87
Link
Blaukat A, Pizard A, Rajerison RM, Alhenc-Gelas F, Müller-Esterl W, Dikic I
Activation of mitogen-activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization.
FEBS Lett
1999.
451
(3)
337-41
Link
Blaukat A, Ivankovic-Dikic I, Grönroos E, Dolfi F, Tokiwa G, Vuori K, Dikic I
Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades.
J Biol Chem
1999.
274
(21)
14893-901
Link
Yamashita H, Avraham S, Jiang S, Dikic I, Avraham H
The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells.
J Biol Chem
1999.
274
(21)
15059-65
Link
Dikic I, Dikic I, Schlessinger J
Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling.
J Biol Chem
1998.
273
(23)
14301-8
Link
Miyazaki T, Takaoka A, Nogueira L, Dikic I, Fujii H, Tsujino S, Mitani Y, Maeda M, Schlessinger J, Taniguchi T
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.
Genes Dev
1998.
12
(6)
770-5
Link
Davis CB, Dikic I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR
Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.
J Exp Med
1997.
186
(10)
1793-8
Link
Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A
Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling.
J Exp Med
1997.
185
(7)
1253-9
Link
Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.
Nature
1996.
383
(6600)
547-50
Link
Tokiwa G, Dikic I, Lev S, Schlessinger J
Activation of Pyk2 by stress signals and coupling with JNK signaling pathway.
Science
1996.
273
(5276)
792-4
Link
Mohammadi M, Dikic I, Sorokin A, Burgess WH, Jaye M, Schlessinger J
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
Mol Cell Biol
1996.
16
(3)
977-89
Link
Dikić I
Regulation of HIV-1 infection by chemokine receptors.
Acta Med Croatica
1996.
50
(4-5)
163-8
Link
Galisteo ML, Dikic I, Batzer AG, Langdon WY, Schlessinger J
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
J Biol Chem
1995.
270
(35)
20242-5
Link
Dikic I, Batzer AG, Blaikie P, Obermeier A, Ullrich A, Schlessinger J, Margolis B
Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain.
J Biol Chem
1995.
270
(25)
15125-9
Link
Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.
Cell
1994.
79
(6)
1015-24
Link
Dikic I, Schlessinger J, Lax I
PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.
Curr Biol
1994.
4
(8)
702-8
Link
Marusić A, Dikić I, Vukicević S, Marusić M
New bone induction by demineralized bone matrix in immunosuppressed rats.
Experientia
1992.
48
(8)
783-5
Link
