Alexis obtained his PhD degree in faculty of sciences, Austral University, Valdivia, Chile. During his Ph.D. research, he studied the role of the proteasome system and autophagy in the degradation and proteolityc processing of amyloid precursor protein (APP). In November 2017, Alexis joined the group of Ivan Dikic as a Postdoctoral researcher investigating how phosphoribosyl-linked serine ubiquitination affects cellular functions as well as ER-phagy mechanism.