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Viruses are an intriguing system to study in terms of host-pathogen interaction. They can remodel host pathways for viral survival and replication. Enveloped positive-sense RNA viruses like coronaviruses have been a clinically important field of research as they cause frequent outbreaks affecting millions of people worldwide. These viruses are well-studied for their replication strategies and cellular entry pathways. However, how viral proteins hijack cellular signaling pathways remains a relatively unexplored area of research. We are currently studying Ub or UBL-specific proteases from coronaviruses like SARS, MERS and Covid-19 to see how these are similar and different from each other in terms of molecular structure, function and interaction with host cellular metabolism.