On this page, all publications originating from or in collaboration with IBC2 are listed. The list does not contain manuscripts which were published by an IBC2 member during a previous employment. For each individual group leader, a full publication record can be found on the respective group page.
Due to the entries in the PubMed database, until 2014 the search string only catches publications in which first or last author were IBC2-affiliated. Manuscripts published in journals not listed on PubMed are listed at the bottom of the page.

Bar-Yosef H, Venezian J, Klann K, Shiber A Purification of Ribosome-Nascent-Chain Complex for Ribosome Profiling and Selective Ribosome Profiling. Methods Mol Biol 2022. 2477 179-193 Link

Demel UM, Böger M, Yousefian S, Grunert C, Zhang L, Hotz PW, Gottschlich A, Köse H, Isaakidis K, Vonficht D, Grünschläger F, Rohleder E, Wagner K, Dönig J, Igl V, Brzezicha B, Baumgartner F, Habringer S, Löber J, Chapuy B, Weidinger C, Kobold S, Haas S, Busse AB, Müller S, et al. Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer. J Clin Invest 2022. 132 (9) Link

Fischer T, Hartmann O, Reissland M, Prieto-Garcia C, Klann K, Pahor N, Schülein-Völk C, Baluapuri A, Polat B, Abazari A, Gerhard-Hartmann E, Kopp HG, Essmann F, Rosenfeldt M, Münch C, Flentje M, Diefenbacher ME PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. Cell Biosci 2022. 12 (1) 50 Link

Gubas A, Dikic I ER remodeling via ER-phagy. Mol Cell 2022. 82 (8) 1492-1500 Link

Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, Eberhardt W, Rajalingam K, Tenzer S, Pfeilschifter J, Imre G The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions. Cell Death Dis 2022. 13 (4) 386 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Bozkurt S, Pahor N, Fuss C, Schirbel A, Schülein-Völk C, Buchberger A, Calzado Canale MA, Rosenfeldt M, Dikic I, Münch C, Diefenbacher ME USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K. Mol Oncol 2022. Link

Djurabekova A, Galemou Yoga E, Nyman A, Pirttikoski A, Zickermann V, Haapanen O, Sharma V Docking and molecular simulations reveal a quinone-binding site on the surface of respiratory complex I. FEBS Lett 2022. 596 (9) 1133-1146 Link

Tomaskovic I, Gonzalez A, Dikic I Ubiquitin and Legionella: From bench to bedside. Semin Cell Dev Biol 2022. Link

Klann K, Münch C Quantitative Translation Proteomics Using mePROD. Methods Mol Biol 2022. 2428 75-87 Link

Klann K, Münch C PBLMM: Peptide-based linear mixed models for differential expression analysis of shotgun proteomics data. J Cell Biochem 2022. 123 (3) 691-696 Link

Kohli A, Sauerhering L, Fehling SK, Klann K, Geiger H, Becker S, Koch B, Baer PC, Strecker T, Münch C Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells. Life Sci Alliance 2022. 5 (5) Link

Hammer A, Cerretti G, Ricciardi DA, Schiffmann D, Maranda S, Kummer R, Zumbühl C, Rattenbacher-Kiser KF, von Arx S, Ammann S, Strobl F, Berkane R, Stolz A, Stelzer EHK, Egli M, Schleiff E, Wuest SL, Böhmer M Retrograde Analysis of Calcium Signaling by CaMPARI2 Shows Cytosolic Calcium in Chondrocytes Is Unaffected by Parabolic Flights. Biomedicines 2022. 10 (1) Link

Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF Mitochondria shed their outer membrane in response to infection-induced stress. Science 2022. 375 (6577) eabi4343 Link

Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, et al. Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Nat Commun 2022. 13 (1) 281 Link

Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J, et al. Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Ann N Y Acad Sci 2022. 1510 (1) 79-99 Link

Baker F, Polat IH, Abou-El-Ardat K, Alshamleh I, Thoelken M, Hymon D, Gubas A, Koschade SE, Vischedyk JB, Kaulich M, Schwalbe H, Shaid S, Brandts CH Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3. Cancers (Basel) 2021. 13 (23) Link

Hotz PW, Müller S, Mendler L SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease. Front Mol Biosci 2021. 8 786136 Link

Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery. Mol Cell 2022. 82 (2) 435-446.e7 Link

Parey K, Lasham J, Mills DJ, Djurabekova A, Haapanen O, Yoga EG, Xie H, Kühlbrandt W, Sharma V, Vonck J, Zickermann V High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Sci Adv 2021. 7 (46) eabj3221 Link

Müller S Managing stress granule disassembly with ubiquitin and its cousin. Signal Transduct Target Ther 2021. 6 (1) 391 Link

Lehmann C, Pohl C A Maternal-Effect Toxin Affects Epithelial Differentiation and Tissue Mechanics in . Front Cell Dev Biol 2021. 9 743496 Link

Prieto-Garcia C, Tomašković I, Shah VJ, Dikic I, Diefenbacher M USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma. Cells 2021. 10 (10) Link

Riegel K, Yurugi H, Schlöder J, Jonuleit H, Kaulich M, Kirschner F, Arnold-Schild D, Tenzer S, Schild H, Rajalingam K ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression. Cell Death Dis 2021. 12 (11) 969 Link

Schünke H, Göbel U, Dikic I, Pasparakis M OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun 2021. 12 (1) 5912 Link

Prieto-Garcia C, Hartmann O, Reissland M, Fischer T, Maier CR, Rosenfeldt M, Schülein-Völk C, Klann K, Kalb R, Dikic I, Münch C, Diefenbacher ME Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. Cell Death Differ 2022. 29 (3) 568-584 Link

Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, Kern A, Behl C, Bremm A The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. J Biol Chem 2021. 297 (5) 101263 Link

Russ N, Schröder M, Berger BT, Mandel S, Aydogan Y, Mauer S, Pohl C, Drewry DH, Chaikuad A, Müller S, Knapp S Design and Development of a Chemical Probe for Pseudokinase Ca/calmodulin-Dependent Ser/Thr Kinase. J Med Chem 2021. 64 (19) 14358-14376 Link

Patra U, Müller S A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity. Front Cell Dev Biol 2021. 9 696234 Link

Schmidt F, Marx A, Baumgarten N, Hebel M, Wegner M, Kaulich M, Leisegang MS, Brandes RP, Göke J, Vreeken J, Schulz MH Integrative analysis of epigenetics data identifies gene-specific regulatory elements. Nucleic Acids Res 2021. 49 (18) 10397-10418 Link

Röhm S, Berger BT, Schröder M, Chatterjee D, Mathea S, Joerger AC, Pinkas DM, Bufton JC, Tjaden A, Kovooru L, Kudolo M, Pohl C, Bullock AN, Müller S, Laufer S, Knapp S Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J Med Chem 2021. 64 (18) 13451-13474 Link

Gama-Brambila RA, Chen J, Dabiri Y, Tascher G, Němec V, Münch C, Song G, Knapp S, Cheng X A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins. JACS Au 2021. 1 (6) 777-785 Link

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, et al. Autophagy in major human diseases. EMBO J 2021. 40 (19) e108863 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Correction: Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2021. 125 (7) 1030 Link

Maculins T, Dikic I Gasdermin B in the host-pathogen tug-of-war. Cell Res 2021. 31 (10) 1043-1044 Link

Reggio A, Buonomo V, Berkane R, Bhaskara RM, Tellechea M, Peluso I, Polishchuk E, Di Lorenzo G, Cirillo C, Esposito M, Hussain A, Huebner AK, Hübner CA, Settembre C, Hummer G, Grumati P, Stolz A Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control. EMBO Rep 2021. 22 (9) e52289 Link

Gerstmeier J, Possmayer AL, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D, Linder B Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel) 2021. 13 (14) Link

Valečka J, Camosseto V, McEwan DG, Terawaki S, Liu Z, Strock E, Almeida CR, Su B, Dikic I, Liang Y, Gatti E, Pierre P RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages. R Soc Open Sci 2021. 8 (7) 202333 Link

Liu Y, Mukherjee R, Bonn F, Colby T, Matic I, Glogger M, Heilemann M, Dikic I Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection. Cell Death Differ 2021. 28 (10) 2957-2969 Link

Kaulich M, Link VM, Lapek JD, Lee YJ, Glass CK, Gonzalez DJ, Dowdy SF A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition. Sci Rep 2021. 11 (1) 14736 Link

Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P, Kulathu Y Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLoS One 2021. 16 (7) e0253364 Link

Lorenz NI, Sittig ACM, Urban H, Luger AL, Engel AL, Münch C, Steinbach JP, Ronellenfitsch MW Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide. Sci Rep 2021. 11 (1) 14161 Link

Schaefer L, Dikic I Autophagy: Instructions from the extracellular matrix. Matrix Biol 2021. 100-101 1-8 Link

Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour AR, Shin D, Khan KS, Hei-Yin Cheung H, Wong KB, Ng WL, Cinatl J, Geurink PP, van der Heden van Noort GJ, Rajalingam K, Ciesek S, Hummer G, Dikic I Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection. J Biol Chem 2021. 297 (2) 100925 Link

Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I, Kögel D BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells. J Cell Biochem 2022. 123 (1) 77-90 Link

Körtel N, Rücklé C, Zhou Y, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J, Zarnack K Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning. Nucleic Acids Res 2021. 49 (16) e92 Link

Maculins T, Verschueren E, Hinkle T, Choi M, Chang P, Chalouni C, Rao S, Kwon Y, Lim J, Katakam AK, Kunz RC, Erickson BK, Huang T, Tsai TH, Vitek O, Reichelt M, Senbabaoglu Y, Mckenzie B, Rohde JR, Dikic I, Kirkpatrick DS, Murthy A Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response. Elife 2021. 10 Link

Kahlhöfer F, Gansen M, Zickermann V Accessory Subunits of the Matrix Arm of Mitochondrial Complex I with a Focus on Subunit NDUFS4 and Its Role in Complex I Function and Assembly. Life (Basel) 2021. 11 (5) Link

Gama-Brambila RA, Chen J, Zhou J, Tascher G, Münch C, Cheng X A PROTAC targets splicing factor 3B1. Cell Chem Biol 2021. 28 (11) 1616-1627.e8 Link

Abudu YP, Shrestha BK, Zhang W, Palara A, Brenne HB, Larsen KB, Wolfson DL, Dumitriu G, Øie CI, Ahluwalia BS, Levy G, Behrends C, Tooze SA, Mouilleron S, Lamark T, Johansen T SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. J Cell Biol 2021. 220 (8) Link

Keiten-Schmitz J, Röder L, Hornstein E, Müller-McNicoll M, Müller S SUMO: Glue or Solvent for Phase-Separated Ribonucleoprotein Complexes and Molecular Condensates? Front Mol Biosci 2021. 8 673038 Link

Galemou Yoga E, Schiller J, Zickermann V Ubiquinone Binding and Reduction by Complex I-Open Questions and Mechanistic Implications. Front Chem 2021. 9 672851 Link

Zhang H, Cao X, Tang M, Zhong G, Si Y, Li H, Zhu F, Liao Q, Li L, Zhao J, Feng J, Li S, Wang C, Kaulich M, Wang F, Chen L, Li L, Xia Z, Liang T, Lu H, Feng XH, Zhao B A subcellular map of the human kinome. Elife 2021. 10 Link

Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, Kaulich M Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res 2021. 49 (10) 5684-5704 Link

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C, Dikic I SIK2 orchestrates actin-dependent host response upon infection. Proc Natl Acad Sci U S A 2021. 118 (19) Link

Kannt A, Đikić I Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation. Cell Chem Biol 2021. 28 (7) 1014-1031 Link

Klann K, Tascher G, Münch C Virus systems biology: Proteomics profiling of dynamic protein networks during infection. Adv Virus Res 2021. 109 1-29 Link

Geßner A, Koch B, Klann K, Fuhrmann DC, Farmand S, Schubert R, Münch C, Geiger H, Baer PC Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells. Int J Mol Sci 2021. 22 (6) Link

Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol 2021. 23 (4) 413-423 Link

Gubas A, Dikic I A guide to the regulation of selective autophagy receptors. FEBS J 2022. 289 (1) 75-89 Link

Acuña-Hinrichsen F, Covarrubias-Pinto A, Ishizuka Y, Stolzenbach MF, Martin C, Salazar P, Castro MA, Bramham CR, Otth C Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines. Front Cell Neurosci 2021. 15 580717 Link

Schwich OD, Blümel N, Keller M, Wegener M, Setty ST, Brunstein ME, Poser I, Mozos IRL, Suess B, Münch C, McNicoll F, Zarnack K, Müller-McNicoll M SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Genome Biol 2021. 22 (1) 82 Link

Baumgarten N, Schmidt F, Wegner M, Hebel M, Kaulich M, Schulz MH Computational prediction of CRISPR-impaired non-coding regulatory regions. Biol Chem 2021. 402 (8) 973-982 Link

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021. 17 (1) 1-382 Link

Kunz P, Lehmann C, Pohl C Differential Thresholds of Proteasome Activation Reveal Two Separable Mechanisms of Sensory Organ Polarization in . Front Cell Dev Biol 2021. 9 619596 Link

Siggel M, Bhaskara RM, Moesser MK, D Ikić I, Hummer G FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes. J Phys Chem Lett 2021. 12 (7) 1926-1931 Link

Mende H, Müller S Surveillance of nucleolar homeostasis and ribosome maturation by autophagy and the ubiquitin-proteasome system. Matrix Biol 2021. 100-101 30-38 Link

Cetin R, Quandt E, Kaulich M Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance. Cells 2021. 10 (2) Link

Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy 2021. 17 (11) 3424-3443 Link

Herhaus L TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease. Matrix Biol 2021. 100-101 84-98 Link

Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS, McEwan DG The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Lett 2021. 595 (7) 864-880 Link

Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W DGK and DZHK position paper on genome editing: basic science applications and future perspective. Basic Res Cardiol 2021. 116 (1) 2 Link

Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I, Tan MW Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Sci Rep 2021. 11 (1) 618 Link

Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, et al. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci 2021. 22 (2) Link

Güllülü Ö, Hehlgans S, Mayer BE, Gößner I, Petraki C, Hoffmann M, Dombrowsky MJ, Kunzmann P, Hamacher K, Strebhardt K, Fokas E, Rödel C, Münch C, Rödel F A Spatial and Functional Interaction of a Heterotetramer Survivin-DNA-PKcs Complex in DNA Damage Response. Cancer Res 2021. 81 (9) 2304-2317 Link

Wiatr M, Staubach S, Figueiredo R, Stump-Guthier C, Ishikawa H, Schwerk C, Schroten H, Hanisch FG, Rudolph H, Tenenbaum T Echovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro. Microorganisms 2020. 8 (12) Link

Hotz PW, Wiesnet M, Tascher G, Braun T, Müller S, Mendler L Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury. Molecules 2020. 25 (23) Link

Galemou Yoga E, Parey K, Djurabekova A, Haapanen O, Siegmund K, Zwicker K, Sharma V, Zickermann V, Angerer H Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. Nat Commun 2020. 11 (1) 6008 Link

Shin D, Bhattacharya A, Cheng YL, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G, Dikic I Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. Elife 2020. 9 Link

Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C BAG3 Proteomic Signature under Proteostasis Stress. Cells 2020. 9 (11) Link

Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Münch C, Wass MN, Michaelis M, Cinatl J Aprotinin Inhibits SARS-CoV-2 Replication. Cells 2020. 9 (11) Link

Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kögel D, van Wijk S ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy 2021. 17 (9) 2432-2448 Link

Bremm A Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S. Sci Signal 2020. 13 (654) Link

Kim RQ, Misra M, Gonzalez A, Tomašković I, Shin D, Schindelin H, Filippov DV, Ovaa H, Đikić I, van der Heden van Noort GJ Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection. Chemistry 2021. 27 (7) 2506-2512 Link

Klann K, Münch C Unbiased translation proteomics upon cell stress. Mol Cell Oncol 2020. 7 (4) 1763150 Link

Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol Cell 2020. 80 (1) 164-174.e4 Link

Eck F, Phuyal S, Smith MD, Kaulich M, Wilkinson S, Farhan H, Behrends C ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis. J Cell Sci 2020. 133 (18) Link

McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? Diagnostics (Basel) 2020. 10 (8) Link

Han Z, Angerer H, Bischoff I, Qin Y, Stegmann D, Tuz K, Fritz G, Juarez O, Fürst R, Lashley D, Nasiri HR Concise Synthesis of 1,4-Benzoquinone-Based Natural Products as Mitochondrial Complex I Substrates and Substrate-Based Inhibitors. ChemMedChem 2020. 15 (24) 2491-2499 Link

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 2020. 587 (7835) 657-662 Link

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chem Biol 2020. 27 (11) 1441-1451.e7 Link

Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh LG, Huebner AK, Cesana M, Bonn F, Polishchuk E, Hübner CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. EMBO J 2020. 39 (17) e105696 Link

Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, Sisignano M The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. Cells 2020. 9 (7) Link

Voelcker G Aldophosphamide-thiazolidine (NSC-613060) an oxazaphosphorine cytostatic that crosses the blood brain barrier. Anticancer Drugs 2021. 32 (1) 61-65 Link

Kenny HC, Tascher G, Ziemianin A, Rudwill F, Zahariev A, Chery I, Gauquelin-Koch G, Barielle MP, Heer M, Blanc S, O'Gorman DJ, Bertile F Effectiveness of Resistive Vibration Exercise and Whey Protein Supplementation Plus Alkaline Salt on the Skeletal Muscle Proteome Following 21 Days of Bed Rest in Healthy Males. J Proteome Res 2020. 19 (8) 3438-3451 Link

Scherr J, Tang Z, Küllmer M, Balser S, Scholz AS, Winter A, Parey K, Rittner A, Grininger M, Zickermann V, Rhinow D, Terfort A, Turchanin A Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy. ACS Nano 2020. 14 (8) 9972-9978 Link

Keiten-Schmitz J, Wagner K, Piller T, Kaulich M, Alberti S, Müller S The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules. Mol Cell 2020. 79 (1) 54-67.e7 Link

Klann K, Münch C Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements. Anal Chem 2020. 92 (12) 8041-8045 Link

Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codée JDC, Filippov DV, van der Heden van Noort GJ Synthesis of Stable NAD Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC. Chembiochem 2020. 21 (20) 2903-2907 Link

Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Nature 2020. 583 (7816) 469-472 Link

Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics 2020. 21 (3) 187-203 Link

Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun 2020. 11 (1) 2039 Link

Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K ERK3/MAPK6 controls IL-8 production and chemotaxis. Elife 2020. 9 Link

Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I, Ernst A Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine. Front Cell Dev Biol 2020. 8 208 Link

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Heumüller SE, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R Author Correction: Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc 2020. 15 (6) 2140 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2020. 122 (9) 1391-1398 Link

Tiku V, Tan MW, Dikic I Mitochondrial Functions in Infection and Immunity. Trends Cell Biol 2020. 30 (4) 263-275 Link

Kliza K, Husnjak K Resolving the Complexity of Ubiquitin Networks. Front Mol Biosci 2020. 7 21 Link

Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J, Dikic I Wss1 Promotes Replication Stress Tolerance by Degrading Histones. Cell Rep 2020. 30 (9) 3117-3126.e4 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med 2020. 12 (4) e11101 Link

Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem 2020. 295 (14) 4526-4540 Link

Parey K, Wirth C, Vonck J, Zickermann V Respiratory complex I - structure, mechanism and evolution. Curr Opin Struct Biol 2020. 63 1-9 Link

Voelcker G Causes and possibilities to circumvent cyclophosphamide toxicity. Anticancer Drugs 2020. 31 (6) 617-622 Link

Biederstädt A, Hassan Z, Schneeweis C, Schick M, Schneider L, Muckenhuber A, Hong Y, Siegers G, Nilsson L, Wirth M, Dantes Z, Steiger K, Schunck K, Langston S, Lenhof HP, Coluccio A, Orben F, Slawska J, Scherger A, Saur D, Müller S, Rad R, Weichert W, Nilsson J, Reichert M, et al. SUMO pathway inhibition targets an aggressive pancreatic cancer subtype. Gut 2020. 69 (8) 1472-1482 Link

Keiten-Schmitz J, Schunck K, Müller S SUMO Chains Rule on Chromatin Occupancy. Front Cell Dev Biol 2019. 7 343 Link

Hannig J, Schäfer H, Ackermann J, Hebel M, Schäfer T, Döring C, Hartmann S, Hansmann ML, Koch I Bioinformatics analysis of whole slide images reveals significant neighborhood preferences of tumor cells in Hodgkin lymphoma. PLoS Comput Biol 2020. 16 (1) e1007516 Link

Mader J, Huber J, Bonn F, Dötsch V, Rogov VV, Bremm A Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. J Biol Chem 2020. 295 (8) 2160-2174 Link

Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I, Heilemann M Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells. Sci Signal 2020. 13 (614) Link

Galemou Yoga E, Angerer H, Parey K, Zickermann V Respiratory complex I - Mechanistic insights and advances in structure determination. Biochim Biophys Acta Bioenerg 2020. 1861 (3) 148153 Link

Wegner M, Husnjak K, Kaulich M Unbiased and Tailored CRISPR/Cas gRNA Libraries by SynthesizingCovalently-closed-circular (3Cs) DNA. Bio Protoc 2020. 10 (1) e3472 Link

Parey K, Haapanen O, Sharma V, Köfeler H, Züllig T, Prinz S, Siegmund K, Wittig I, Mills DJ, Vonck J, Kühlbrandt W, Zickermann V High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Sci Adv 2019. 5 (12) eaax9484 Link

Klann K, Tascher G, Münch C Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α. Mol Cell 2020. 77 (4) 913-925.e4 Link

Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Mol Cell 2020. 77 (1) 164-179.e6 Link

Pohl C, Dikic I Cellular quality control by the ubiquitin-proteasome system and autophagy. Science 2019. 366 (6467) 818-822 Link

Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease. EMBO Rep 2020. 21 (1) e48317 Link

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Elisabeth Heumüller S, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc 2019. 14 (12) 3395-3425 Link

Hübner CA, Dikic I ER-phagy and human diseases. Cell Death Differ 2020. 27 (3) 833-842 Link

Dutta P, Odedra D, Pohl C Planar Asymmetries in the Embryo Emerge by Differential Retention of aPARs at Cell-Cell Contacts. Front Cell Dev Biol 2019. 7 209 Link

Buchbender A, Mutter H, Sutandy FXR, Körtel N, Hänel H, Busch A, Ebersberger S, König J Improved library preparation with the new iCLIP2 protocol. Methods 2020. 178 33-48 Link

Wagner K, Kunz K, Piller T, Tascher G, Hölper S, Stehmeier P, Keiten-Schmitz J, Schick M, Keller U, Müller S The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics. Cell Rep 2019. 29 (2) 480-494.e5 Link

Pitzius S, Osterburg C, Gebel J, Tascher G, Schäfer B, Zhou H, Münch C, Dötsch V TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain. Cell Death Dis 2019. 10 (10) 686 Link

Singh D, Odedra D, Dutta P, Pohl C Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis. J Cell Sci 2019. 132 (19) Link

Stolz A, Grumati P The various shades of ER-phagy. FEBS J 2019. 286 (23) 4642-4649 Link

Hoock SC, Ritter A, Steinhäuser K, Roth S, Behrends C, Oswald F, Solbach C, Louwen F, Kreis NN, Yuan J RITA modulates cell migration and invasion by affecting focal adhesion dynamics. Mol Oncol 2019. 13 (10) 2121-2141 Link

Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease. Ann Neurol 2019. 86 (4) 593-606 Link

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. Nature 2019. 572 (7769) 382-386 Link

Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy. Biochim Biophys Acta Mol Cell Res 2019. 1866 (10) 1556-1566 Link

Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nat Microbiol 2019. 4 (9) 1516-1531 Link

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J Mol Biol 2019. 431 (17) 3146-3156 Link

Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics. Biochim Biophys Acta Bioenerg 2019. 1860 (7) 573-581 Link

Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy. Nat Commun 2019. 10 (1) 2370 Link

Scherr J, Neuhaus A, Parey K, Klusch N, Murphy BJ, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy. ACS Nano 2019. 13 (6) 7185-7190 Link

Mukherjee R, Dikic I NIPSNAP Beacons in Mitophagy. Dev Cell 2019. 49 (4) 503-505 Link

Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunz K, Hoelper S, Zia-Chahabi S, Jabagi MJ, Emmerich J, Dray-Spira R, Kuhlee F, Hackmann K, Schroeck E, Wenzel P, Müller S, Filmann N, Fontenay M, Pajevic PD, Krause DS Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis. Blood 2019. 134 (3) 227-238 Link

Misra M, Dikic I RNA binding to p62 impacts selective autophagy. Cell Res 2019. 29 (7) 512-513 Link

Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5. Autophagy 2020. 16 (2) 256-270 Link

Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J 2019. 38 (10) Link

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science 2019. 364 (6436) 188-193 Link

Tiku V, Dikic I Autophagy without conjugation. Nat Struct Mol Biol 2019. 26 (4) 249-250 Link

Graab P, Bock C, Weiss K, Hirth A, Koller N, Braner M, Jung J, Loehr F, Tampé R, Behrends C, Abele R Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues. J Biol Chem 2019. 294 (18) 7308-7323 Link

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling. Cancers (Basel) 2019. 11 (3) Link

Voelcker G Oxazaphosphorine cytostatics: from serendipity to rational drug design. Anticancer Drugs 2019. 30 (5) 435-440 Link

Kunz K, Müller S, Mendler L Assays of SUMO protease/isopeptidase activity and function in mammalian cells and tissues. Methods Enzymol 2019. 618 389-410 Link

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife 2019. 8 Link

Bencsik P, Kiss K, Ágg B, Baán JA, Ágoston G, Varga A, Gömöri K, Mendler L, Faragó N, Zvara Á, Sántha P, Puskás LG, Jancsó G, Ferdinandy P Sensory Neuropathy Affects Cardiac miRNA Expression Network Targeting , , , and mRNAs. Int J Mol Sci 2019. 20 (4) Link

Tascher G, Burban A, Camus S, Plumel M, Chanon S, Le Guevel R, Shevchenko V, Van Dorsselaer A, Lefai E, Guguen-Guillouzo C, Bertile F In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes. Cells 2019. 8 (2) Link

Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif. Protein Sci 2019. 28 (5) 848-856 Link

Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem J 2019. 476 (5) 875-887 Link

Fottner M, Brunner AD, Bittl V, Horn-Ghetko D, Jussupow A, Kaila VRI, Bremm A, Lang K Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase. Nat Chem Biol 2019. 15 (3) 276-284 Link

Key J, Mueller AK, Gispert S, Matschke L, Wittig I, Corti O, Münch C, Decher N, Auburger G Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol Dis 2019. 127 114-130 Link

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int 2019. 95 (3) 540-562 Link

van Wijk SJ, Fulda S, Dikic I, Heilemann M Visualizing ubiquitination in mammalian cells. EMBO Rep 2019. 20 (2) Link

Juretschke T, Beli P, Dikic I Quantitative Phosphoproteomics of Selective Autophagy Receptors. Methods Mol Biol 2019. 1880 691-701 Link

Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M The next decade of metabolism. Nat Metab 2019. 1 (1) 2-4 Link

Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J 2019. 38 (2) Link

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood 2019. 133 (2) 168-179 Link

Dikic I Open questions: why should we care about ER-phagy and ER remodelling? BMC Biol 2018. 16 (1) 131 Link

Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps. Nat Commun 2018. 9 (1) 4500 Link

Herhaus L, Dikic I Dimerization quality control via ubiquitylation. Science 2018. 362 (6411) 151-152 Link

Kenne E, Rasmuson J, Renné T, Vieira ML, Müller-Esterl W, Herwald H, Lindbom L Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation. FASEB J 2019. 33 (2) 2599-2609 Link

Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kühlbrandt W, Zickermann V Cryo-EM structure of respiratory complex I at work. Elife 2018. 7 Link

Bonn F, Maaß S, van Dijl JM Enrichment of Cell Surface-Associated Proteins in Gram-Positive Bacteria by Biotinylation or Trypsin Shaving for Mass Spectrometry Analysis. Methods Mol Biol 2018. 1841 35-43 Link

Bonn F, Otto A Protein Enrichment from Highly Dilute Samples with StrataClean. Methods Mol Biol 2018. 1841 11-18 Link

Gärtner A, Wagner K, Hölper S, Kunz K, Rodriguez MS, Müller S Acetylation of SUMO2 at lysine 11 favors the formation of non-canonical SUMO chains. EMBO Rep 2018. 19 (11) Link

Grumati P, Dikic I, Stolz A ER-phagy at a glance. J Cell Sci 2018. 131 (17) Link

Castagnaro S, Chrisam M, Cescon M, Braghetta P, Grumati P, Bonaldo P Extracellular Collagen VI Has Prosurvival and Autophagy Instructive Properties in Mouse Fibroblasts. Front Physiol 2018. 9 1129 Link

Lang F, Khaghani S, Türk C, Wiederstein JL, Hölper S, Piller T, Nogara L, Blaauw B, Günther S, Müller S, Braun T, Krüger M Single Muscle Fiber Proteomics Reveals Distinct Protein Changes in Slow and Fast Fibers during Muscle Atrophy. J Proteome Res 2018. 17 (10) 3333-3347 Link

Flach H, Krieg J, Hoffmeister M, Dietmann P, Reusch A, Wischmann L, Kernl B, Riegger R, Oess S, Kühl SJ Nosip functions during vertebrate eye and cranial cartilage development. Dev Dyn 2018. 247 (9) 1070-1082 Link

Münch C The different axes of the mammalian mitochondrial unfolded protein response. BMC Biol 2018. 16 (1) 81 Link

Neuss S, Bartel Y, Born C, Weil S, Koch J, Behrends C, Hoffmeister M, Steinle A Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80. J Immunol 2018. 201 (4) 1275-1286 Link

Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy 2018. 14 (10) 1693-1709 Link

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, et al. Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell 2018. 174 (1) 88-101.e16 Link

Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Nature 2018. 557 (7707) 734-738 Link

Wiederstein JL, Nolte H, Günther S, Piller T, Baraldo M, Kostin S, Bloch W, Schindler N, Sandri M, Blaauw B, Braun T, Hölper S, Krüger M Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep 2018. 23 (5) 1342-1356 Link

Münch C, Dikic I Publisher Correction: Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (8) 990 Link

Zöller T, Wittenbrink M, Hoffmeister M, Steinle A Cutting an NKG2D Ligand Short: Cellular Processing of the Peculiar Human NKG2D Ligand ULBP4. Front Immunol 2018. 9 620 Link

Kolb J, Anders-Maurer M, Müller T, Hau AC, Grebbin BM, Kallenborn-Gerhardt W, Behrends C, Schulte D Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors. Stem Cell Reports 2018. 10 (4) 1184-1192 Link

Dikic I, Elazar Z Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol 2018. 19 (6) 349-364 Link

Herhaus L, Dikic I Ubiquitin-induced phase separation of p62/SQSTM1. Cell Res 2018. 28 (4) 389-390 Link

Kunz K, Piller T, Müller S SUMO-specific proteases and isopeptidases of the SENP family at a glance. J Cell Sci 2018. 131 (6) Link

Wegner MS, Schömel N, Gruber L, Örtel SB, Kjellberg MA, Mattjus P, Kurz J, Trautmann S, Peng B, Wegner M, Kaulich M, Ahrends R, Geisslinger G, Grösch S UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells. Cell Mol Life Sci 2018. 75 (18) 3393-3410 Link

Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun 2018. 9 (1) 1017 Link

Voelcker G Immunostimulating and cancer-reductive experimental therapy with the oxazaphosphorine cytostatic SUM-IAP. Anticancer Drugs 2018. 29 (5) 411-415 Link

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells. Neoplasia 2018. 20 (3) 263-279 Link

Münch C, Dikic I Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (2) 122-124 Link

Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife 2018. 7 Link

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Structure 2018. 26 (2) 249-258.e4 Link

Ramadan K, Dikic I Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response. Front Genet 2017. 8 188 Link

Voelcker G Influence of the alkylating function of aldo-Ifosfamide on the anti-tumor activity. Anticancer Drugs 2018. 29 (1) 75-79 Link

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angew Chem Int Ed Engl 2018. 57 (6) 1659-1662 Link

Varga ZV, Pipicz M, Baán JA, Baranyai T, Koncsos G, Leszek P, Kuśmierczyk M, Sánchez-Cabo F, García-Pavía P, Brenner GJ, Giricz Z, Csont T, Mendler L, Lara-Pezzi E, Pacher P, Ferdinandy P Alternative Splicing of NOX4 in the Failing Human Heart. Front Physiol 2017. 8 935 Link

Stolz A, Dikic I Heterotypic Ubiquitin Chains: Seeing is Believing. Trends Cell Biol 2018. 28 (1) 1-3 Link

Grumati P, Dikic I Ubiquitin signaling and autophagy. J Biol Chem 2018. 293 (15) 5404-5413 Link

Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring. Proc Natl Acad Sci U S A 2017. 114 (49) 13042-13047 Link

Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, Behrends C Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell 2017. 68 (4) 786-796.e6 Link

Newman AC, Kemp AJ, Drabsch Y, Behrends C, Wilkinson S Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins. Nat Commun 2017. 8 (1) 1537 Link

Herhaus L, Dikic I Regulation of Salmonella-host cell interactions via the ubiquitin system. Int J Med Microbiol 2018. 308 (1) 176-184 Link

Ilina EI, Armento A, Sanchez LG, Reichlmeir M, Braun Y, Penski C, Capper D, Sahm F, Jennewein L, Harter PN, Zukunft S, Fleming I, Schulte D, Le Guerroué F, Behrends C, Ronellenfitsch MW, Naumann U, Mittelbronn M Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget 2017. 8 (40) 67567-67591 Link

Jung J, Behrends C Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures. Bio Protoc 2017. 7 (17) 27982478 Link

Arkan MC The intricate connection between diet, microbiota, and cancer: A jigsaw puzzle. Semin Immunol 2017. 32 35-42 Link

Angerer H, Schönborn S, Gorka J, Bahr U, Karas M, Wittig I, Heidler J, Hoffmann J, Morgner N, Zickermann V Acyl modification and binding of mitochondrial ACP to multiprotein complexes. Biochim Biophys Acta Mol Cell Res 2017. 1864 (10) 1913-1920 Link

Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov VV, Rodriguez MS, Dötsch V, Müller S, Ernst A Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. J Biol Chem 2017. 292 (37) 15340-15351 Link

Polajnar M, Dietz MS, Heilemann M, Behrends C Expanding the host cell ubiquitylation machinery targeting cytosolic . EMBO Rep 2017. 18 (9) 1572-1585 Link

Amstein L, Ackermann J, Scheidel J, Fulda S, Dikic I, Koch I Manatee invariants reveal functional pathways in signaling networks. BMC Syst Biol 2017. 11 (1) 72 Link

Aguilera-Gomez A, Zacharogianni M, van Oorschot MM, Genau H, Grond R, Veenendaal T, Sinsimer KS, Gavis ER, Behrends C, Rabouille C Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation. Cell Rep 2017. 20 (4) 935-948 Link

Jung J, Behrends C Multifaceted role of SMCR8 as autophagy regulator. Small GTPases 2020. 11 (1) 53-61 Link

Hoffmeister M, Krieg J, Ehrke A, Seigfried FA, Wischmann L, Dietmann P, Kühl SJ, Oess S Developmental neurogenesis in mouse and Xenopus is impaired in the absence of Nosip. Dev Biol 2017. 429 (1) 200-212 Link

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep 2017. 18 (8) 1382-1396 Link

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. Elife 2017. 6 Link

Scherr J, Parey K, Klusch N, Murphy BJ, Balser S, Neuhaus A, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy. ACS Nano 2017. 11 (6) 6467-6473 Link

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, et al. Molecular definitions of autophagy and related processes. EMBO J 2017. 36 (13) 1811-1836 Link

Wesely J, Steiner M, Schnütgen F, Kaulich M, Rieger MA, Zörnig M Delayed Mesoderm and Erythroid Differentiation of Murine Embryonic Stem Cells in the Absence of the Transcriptional Regulator FUBP1. Stem Cells Int 2017. 2017 5762301 Link

Lang F, Aravamudhan S, Nolte H, Türk C, Hölper S, Müller S, Günther S, Blaauw B, Braun T, Krüger M Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy. Dis Model Mech 2017. 10 (7) 881-896 Link

Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell 2017. 66 (4) 517-532.e9 Link

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation. Nat Microbiol 2017. 2 17066 Link

Dikic I Proteasomal and Autophagic Degradation Systems. Annu Rev Biochem 2017. 86 193-224 Link

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. Sci Rep 2017. 7 (1) 1131 Link

Pohl C The Midbody and its Remnant in Cell Polarization and Asymmetric Cell Division. Results Probl Cell Differ 2017. 61 165-182 Link

Nayak A, Reck A, Morsczeck C, Müller S Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct genes. Epigenetics Chromatin 2017. 10 15 Link

Šprung M, Dikic I, Novak I Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy. Methods Mol Biol 2018. 1759 105-110 Link

Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R, et al. Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Res 2017. 27 (5) 657-674 Link

Kliza K, Taumer C, Pinzuti I, Franz-Wachtel M, Kunzelmann S, Stieglitz B, Macek B, Husnjak K Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Nat Methods 2017. 14 (5) 504-512 Link

Manczyk N, Yates BP, Veggiani G, Ernst A, Sicheri F, Sidhu SS Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif. Protein Sci 2017. 26 (5) 1060-1069 Link

Krishnathas R, Bonke E, Dröse S, Zickermann V, Nasiri HR Identification of 4--[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I. Medchemcomm 2017. 8 (3) 657-661 Link

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife 2017. 6 Link

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Nat Commun 2017. 8 14004 Link

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 2017. 214 (2) 423-437 Link

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO J 2017. 36 (4) 549-564 Link

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function. EMBO J 2017. 36 (3) 260-273 Link

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Cell 2016. 167 (6) 1636-1649.e13 Link

Tooze SA, Dikic I Autophagy Captures the Nobel Prize. Cell 2016. 167 (6) 1433-1435 Link

Scheidel J, Amstein L, Ackermann J, Dikic I, Koch I In Silico Knockout Studies of Xenophagic Capturing of Salmonella. PLoS Comput Biol 2016. 12 (12) e1005200 Link

Seczynska M, Dikic I Removing the waste bags: how p97 drives autophagy of lysosomes. EMBO J 2017. 36 (2) 129-131 Link

Kahlhöfer F, Kmita K, Wittig I, Zwicker K, Zickermann V Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I. Biochim Biophys Acta Bioenerg 2017. 1858 (2) 175-181 Link

Muller S, Nayak A Inhibition of MLL1 histone methyltransferase brings the developmental clock back to naïve pluripotency. Stem Cell Investig 2016. 3 58 Link

Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Elife 2016. 5 Link

Hoeller D, Dikic I How the proteasome is degraded. Proc Natl Acad Sci U S A 2016. 113 (47) 13266-13268 Link

Raman N, Weir E, Müller S The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling. Mol Cell 2016. 64 (3) 607-615 Link

D'Imprima E, Mills DJ, Parey K, Brandt U, Kühlbrandt W, Zickermann V, Vonck J Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism. Biochim Biophys Acta 2016. 1857 (12) 1935-1942 Link

Altmann C, Hardt S, Fischer C, Heidler J, Lim HY, Häussler A, Albuquerque B, Zimmer B, Möser C, Behrends C, Koentgen F, Wittig I, Schmidt MHH, Clement AM, Deller T, Tegeder I Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiol Dis 2016. 96 294-311 Link

Castagnaro S, Pellegrini C, Pellegrini M, Chrisam M, Sabatelli P, Toni S, Grumati P, Ripamonti C, Pratelli L, Maraldi NM, Cocchi D, Righi V, Faldini C, Sandri M, Bonaldo P, Merlini L Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial. Autophagy 2016. 12 (12) 2484-2495 Link

Husnjak K, Keiten-Schmitz J, Müller S Identification and Characterization of SUMO-SIM Interactions. Methods Mol Biol 2016. 1475 79-98 Link

Kunz K, Wagner K, Mendler L, Hölper S, Dehne N, Müller S SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases. Cell Rep 2016. 16 (11) 3075-3086 Link

Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication. J Cell Biol 2016. 214 (5) 619-35 Link

Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. Diabetes 2016. 65 (12) 3667-3679 Link

Weishaupt JH, Hyman T, Dikic I Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Trends Mol Med 2016. 22 (9) 769-783 Link

Bionda T, Behrends C Unveiling ubiquitinome rearrangements induced by Salmonella infection. Autophagy 2016. 12 (9) 1683-4 Link

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol 2016. 214 (2) 155-66 Link

Hahn A, Parey K, Bublitz M, Mills DJ, Zickermann V, Vonck J, Kühlbrandt W, Meier T Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology. Mol Cell 2016. 63 (3) 445-56 Link

Genau HM, Behrends C GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling. Mol Cell Oncol 2016. 3 (1) e1027440 Link

Brandes RP, Harenkamp S, Schürmann C, Josipovic I, Rashid B, Rezende F, Löwe O, Moll F, Epah J, Eresch J, Nayak A, Kopaliani I, Penski C, Mittelbronn M, Weissmann N, Schröder K The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype. Arterioscler Thromb Vasc Biol 2016. 36 (8) 1558-65 Link

Fiskin E, Bionda T, Dikic I, Behrends C Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Mol Cell 2016. 62 (6) 967-981 Link

Bhogaraju S, Dikic I Cell biology: Ubiquitination without E1 and E2 enzymes. Nature 2016. 533 (7601) 43-4 Link

Strecker V, Kadeer Z, Heidler J, Cruciat CM, Angerer H, Giese H, Pfeiffer K, Stuart RA, Wittig I Supercomplex-associated Cox26 protein binds to cytochrome c oxidase. Biochim Biophys Acta 2016. 1863 (7 Pt A) 1643-52 Link

Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. FEBS J 2016. 283 (11) 2004-17 Link

Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A 2016. 113 (15) 4039-44 Link

Baccarini M, Dikic I Editorial overview: Cell regulation. Curr Opin Cell Biol 2016. 39 iv-vi Link

Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, Schaefer L An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. Am J Pathol 2016. 186 (5) 1206-20 Link

Maculins T, Fiskin E, Bhogaraju S, Dikic I Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res 2016. 26 (4) 499-510 Link

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget 2016. 7 (15) 20016-32 Link

Voelcker G Enhancement of antitumor activity of the oxazaphosphorine cytostatic SUM-IAP by N-methylformamide. J Cancer Res Clin Oncol 2016. 142 (6) 1183-9 Link

Singh D, Odedra D, Lehmann C, Pohl C Acute heat shock leads to cortical domain internalization and polarity loss in the C. elegans embryo. Genesis 2016. 54 (4) 220-8 Link

Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. J Biol Chem 2016. 291 (17) 9025-41 Link

Wirth C, Brandt U, Hunte C, Zickermann V Structure and function of mitochondrial complex I. Biochim Biophys Acta 2016. 1857 (7) 902-14 Link

Rajalingam K, Dikic I SnapShot: Expanding the Ubiquitin Code. Cell 2016. 164 (5) 1074-1074.e1 Link

Akutsu M, Dikic I, Bremm A Ubiquitin chain diversity at a glance. J Cell Sci 2016. 129 (5) 875-80 Link

Mora J, Schlemmer A, Wittig I, Richter F, Putyrski M, Frank AC, Han Y, Jung M, Ernst A, Weigert A, Brüne B Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol 2016. 8 (5) 426-438 Link

Mendler L, Braun T, Müller S The Ubiquitin-Like SUMO System and Heart Function: From Development to Disease. Circ Res 2016. 118 (1) 132-44 Link

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016. 12 (1) 1-222 Link

Gomes LC, Odedra D, Dikic I, Pohl C Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans. Autophagy 2016. 12 (3) 529-46 Link

Lamb CA, Nühlen S, Judith D, Frith D, Snijders AP, Behrends C, Tooze SA TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. EMBO J 2016. 35 (3) 281-301 Link

Dutta P, Lehmann C, Odedra D, Singh D, Pohl C Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools. J Vis Exp 2015. (106) e53469 Link

Bionda T, Gross LE, Becker T, Papasotiriou DG, Leisegang MS, Karas M, Schleiff E Eukaryotic Hsp70 chaperones in the intermembrane space of chloroplasts. Planta 2016. 243 (3) 733-47 Link

Vetter T, Borowski A, Wohlmann A, Ranjan N, Kuepper M, Badura S, Ottmann OG, Friedrich K Blockade of thymic stromal lymphopoietin (TSLP) receptor inhibits TSLP-driven proliferation and signalling in lymphoblasts from a subset of B-precursor ALL patients. Leuk Res 2016. 40 38-43 Link

Chrisam M, Pirozzi M, Castagnaro S, Blaauw B, Polishchuck R, Cecconi F, Grumati P, Bonaldo P Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice. Autophagy 2015. 11 (12) 2142-52 Link

Khaminets A, Behl C, Dikic I Ubiquitin-Dependent And Independent Signals In Selective Autophagy. Trends Cell Biol 2016. 26 (1) 6-16 Link

Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export. Mol Cell 2015. 60 (1) 89-104 Link

Jaé N, McEwan DG, Manavski Y, Boon RA, Dimmeler S Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles. FEBS Lett 2015. 589 (20 Pt B) 3182-8 Link

Herhaus L, Dikic I Expanding the ubiquitin code through post-translational modification. EMBO Rep 2015. 16 (9) 1071-83 Link

Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S Binding of SGTA to Rpn13 selectively modulates protein quality control. J Cell Sci 2015. 128 (17) 3187-96 Link

Kovacevic I, Müller M, Kojonazarov B, Ehrke A, Randriamboavonjy V, Kohlstedt K, Hindemith T, Schermuly RT, Fleming I, Hoffmeister M, Oess S The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function. Circ Res 2015. 117 (5) 460-9 Link

Clemen CS, Marko M, Strucksberg KH, Behrens J, Wittig I, Gärtner L, Winter L, Chevessier F, Matthias J, Türk M, Tangavelou K, Schütz J, Arhzaouy K, Klopffleisch K, Hanisch FG, Rottbauer W, Blümcke I, Just S, Eichinger L, Hofmann A, Schröder R VCP and PSMF1: Antagonistic regulators of proteasome activity. Biochem Biophys Res Commun 2015. 463 (4) 1210-7 Link

Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 2015. 522 (7556) 354-8 Link

Jung J, Genau HM, Behrends C Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Mol Cell Biol 2015. 35 (14) 2479-94 Link

McEwan DG, Dikic I PLEKHM1: Adapting to life at the lysosome. Autophagy 2015. 11 (4) 720-2 Link

Kmita K, Wirth C, Warnau J, Guerrero-Castillo S, Hunte C, Hummer G, Kaila VR, Zwicker K, Brandt U, Zickermann V Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I. Proc Natl Acad Sci U S A 2015. 112 (18) 5685-90 Link

Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, et al. Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci 2015. 18 (5) 631-6 Link

Dubrez L, Rajalingam K IAPs and cell migration. Semin Cell Dev Biol 2015. 39 124-31 Link

Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, Schnütgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem 2015. 290 (15) 9738-52 Link

Angerer H Eukaryotic LYR Proteins Interact with Mitochondrial Protein Complexes. Biology (Basel) 2015. 4 (1) 133-50 Link

Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. Mol Cell 2015. 57 (6) 995-1010 Link

Tamura N, Simon JE, Nayak A, Shenoy RT, Hiroi N, Boilot V, Funahashi A, Draviam VM A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset. Biol Open 2015. 4 (2) 155-69 Link

Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I. Science 2015. 347 (6217) 44-9 Link

Hoffmeister M, Prelle C, Küchler P, Kovacevic I, Moser M, Müller-Esterl W, Oess S The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PLoS One 2014. 9 (12) e116150 Link

McEwan DG, Dikic I Cullins keep autophagy under control. Dev Cell 2014. 31 (6) 675-6 Link

Stolz A, Dikic I PINK1-PARKIN interplay: down to ubiquitin phosphorylation. Mol Cell 2014. 56 (3) 341-342 Link

McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection. Cell Host Microbe 2015. 17 (1) 58-71 Link

McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol Cell 2015. 57 (1) 39-54 Link

Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife 2014. 3 Link

Popovic D, Vucic D, Dikic I Ubiquitination in disease pathogenesis and treatment. Nat Med 2014. 20 (11) 1242-53 Link

Bremm A, Moniz S, Mader J, Rocha S, Komander D Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner. EMBO Rep 2014. 15 (12) 1268-77 Link

Singh D, Pohl C A function for the midbody remnant in embryonic patterning. Commun Integr Biol 2014. 7 e28533 Link

Raman N, Nayak A, Muller S mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3. Mol Cell Biol 2014. 34 (24) 4474-84 Link

Dikic I, Bremm A DUBs counteract parkin for efficient mitophagy. EMBO J 2014. 33 (21) 2442-3 Link

Schulenburg K, Glatz G, Remenyi A, Rajalingam K Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade. Mol Cell Oncol . 1 (4) e969170 Link

Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, et al. Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet 2014. 46 (11) 1239-44 Link

Bhogaraju S, Dikic I A peek into the atomic details of thalidomide's clinical effects. Nat Struct Mol Biol 2014. 21 (9) 739-40 Link

Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 2014. 10 (10) 1749-60 Link

Mooz J, Oberoi-Khanuja TK, Harms GS, Wang W, Jaiswal BS, Seshagiri S, Tikkanen R, Rajalingam K Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. Sci Signal 2014. 7 (337) ra73 Link

Gärtner A, Muller S PML, SUMO, and RNF4: guardians of nuclear protein quality. Mol Cell 2014. 55 (1) 1-3 Link

Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J 2014. 33 (16) 1784-801 Link

Nayak A, Viale-Bouroncle S, Morsczeck C, Muller S The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation. Mol Cell 2014. 55 (1) 47-58 Link

Stolz A, Ernst A, Dikic I Cargo recognition and trafficking in selective autophagy. Nat Cell Biol 2014. 16 (6) 495-501 Link

Lu J, He L, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat Commun 2014. 5 3920 Link

López-Mosqueda J, Dikic I Deciphering functions of branched ubiquitin chains. Cell 2014. 157 (4) 767-9 Link

Gomes LC, Dikic I Autophagy in antimicrobial immunity. Mol Cell 2014. 54 (2) 224-33 Link

Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling. Mol Cell 2014. 54 (3) 349-61 Link

Angerer H, Radermacher M, Mańkowska M, Steger M, Zwicker K, Heide H, Wittig I, Brandt U, Zickermann V The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity. Proc Natl Acad Sci U S A 2014. 111 (14) 5207-12 Link

Grumati P, Dikic I Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling. Cancer Discov 2014. 4 (4) 394-6 Link

Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chem Biol 2014. 21 (4) 552-562 Link

Popovic D, Dikic I TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO Rep 2014. 15 (4) 392-401 Link

Singh D, Pohl C Coupling of rotational cortical flow, asymmetric midbody positioning, and spindle rotation mediates dorsoventral axis formation in C. elegans. Dev Cell 2014. 28 (3) 253-67 Link

Wild P, McEwan DG, Dikic I The LC3 interactome at a glance. J Cell Sci 2014. 127 (Pt 1) 3-9 Link

Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, Kumar KG, Butler AA, Bannister TD, Hooper AT, Unsal-Kacmaz K, Roush WR, Cleveland JL Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Res 2014. 74 (3) 908-20 Link

Murali A, Rajalingam K Small Rho GTPases in the control of cell shape and mobility. Cell Mol Life Sci 2014. 71 (9) 1703-21 Link

Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature 2013. 503 (7476) 422-426 Link

Camargo LL, Babelova A, Mieth A, Weigert A, Mooz J, Rajalingam K, Heide H, Wittig I, Lopes LR, Brandes RP Endo-PDI is required for TNFα-induced angiogenesis. Free Radic Biol Med 2013. 65 1398-1407 Link

Angerer H The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins. Biochem Soc Trans 2013. 41 (5) 1335-41 Link

Kmita K, Zickermann V Accessory subunits of mitochondrial complex I. Biochem Soc Trans 2013. 41 (5) 1272-9 Link

Oberoi-Khanuja TK, Murali A, Rajalingam K IAPs on the move: role of inhibitors of apoptosis proteins in cell migration. Cell Death Dis 2013. 4 e784 Link

Raman N, Nayak A, Muller S The SUMO system: a master organizer of nuclear protein assemblies. Chromosoma 2013. 122 (6) 475-85 Link

van Wijk SJ, Fiškin E, Dikic I Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors. Nat Protoc 2013. 8 (7) 1449-58 Link

Olma MH, Dikic I Cullins getting undressed by the protein exchange factor Cand1. Cell 2013. 153 (1) 14-6 Link

Fiškin E, Dikic I Parkin promotes cell survival via linear ubiquitination. EMBO J 2013. 32 (8) 1072-4 Link

Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods 2013. 10 (4) 361-5 Link

van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol Cell 2012. 47 (5) 797-809 Link

Oberoi-Khanuja TK, Rajalingam K IAPs as E3 ligases of Rac1: shaping the move. Small GTPases . 3 (2) 131-6 Link

Kovacevic I, Hu J, Siehoff-Icking A, Opitz N, Griffin A, Perkins AC, Munn AL, Müller-Esterl W, Popp R, Fleming I, Jungblut B, Hoffmeister M, Oess S The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development. EMBO J 2012. 31 (15) 3309-22 Link

Shaid S, Brandts CH, Serve H, Dikic I Ubiquitination and selective autophagy. Cell Death Differ 2013. 20 (1) 21-30 Link

Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem 2012. 287 (34) 28445-55 Link

Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. J Biol Chem 2012. 287 (28) 23626-34 Link

Ullmann R, Chien CD, Avantaggiati ML, Muller S An acetylation switch regulates SUMO-dependent protein interaction networks. Mol Cell 2012. 46 (6) 759-70 Link

Rahighi S, Dikic I Selectivity of the ubiquitin-binding modules. FEBS Lett 2012. 586 (17) 2705-10 Link

Behrends C, Fulda S Receptor proteins in selective autophagy. Int J Cell Biol 2012. 2012 673290 Link

Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J 2012. 31 (11) 2615-28 Link

Husnjak K, Dikic I Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem 2012. 81 291-322 Link

Dikic I Ivan Dikic was trained as a medical doctor at the University of Zagreb, Croatia. Curr Biol 2012. 22 (3) R76-7 Link

Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol 2012. 32 (9) 1733-44 Link

van Wijk SJ, Bienko M, Dikic I Role of UbL family modifiers and their binding proteins in cell signaling. Methods Mol Biol 2012. 832 163-71 Link

Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J 2012. 31 (1) 14-28 Link

Imre G, Larisch S, Rajalingam K Ripoptosome: a novel IAP-regulated cell death-signalling platform. J Mol Cell Biol 2011. 3 (6) 324-6 Link

van Wijk SJ, Müller S, Dikic I Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair. Genes Dev 2011. 25 (17) 1763-9 Link

Rajalingam K, Dikic I Healthy ageing through regulated proteostasis. EMBO J 2011. 30 (15) 2983-5 Link

Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 2011. 333 (6039) 228-33 Link

Behrends C, Harper JW Constructing and decoding unconventional ubiquitin chains. Nat Struct Mol Biol 2011. 18 (5) 520-8 Link

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 2011. 471 (7340) 637-41 Link

Rajalingam K, van der Goot FG When cells and microbes meet in Krakow. EMBO Rep 2011. 12 (3) 188-90 Link

McEwan DG, Dikic I The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol 2011. 21 (4) 195-201 Link

Ikeda F, Rahighi S, Wakatsuki S, Dikic I Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation. Adv Exp Med Biol 2011. 691 107-14 Link

Åkesson P, Herwald H, Rasmussen M, HÅkansson K, Abrahamson M, Hasan AAK, Schmaier AH, Müller-Esterl W, Björck L Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant. Microbiology (Reading) 2010. 156 (Pt 12) 3660-3668 Link

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, et al. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J 2010. 29 (14) 2421-32 Link

Deribe YL, Pawson T, Dikic I Post-translational modifications in signal integration. Nat Struct Mol Biol 2010. 17 (6) 666-72 Link

Dikic I, Schmidt MHH Notch: Implications of endogenous inhibitors for therapy. Bioessays 2010. 32 (6) 481-487 Link

Dikic I, Johansen T, Kirkin V Selective autophagy in cancer development and therapy. Cancer Res 2010. 70 (9) 3431-4 Link

Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell 2010. 37 (3) 396-407 Link

Wild P, Dikic I Mitochondria get a Parkin' ticket. Nat Cell Biol 2010. 12 (2) 104-6 Link

Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MHH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal 2009. 2 (102) ra84 Link

Dikic I, Dötsch V Ubiquitin linkages make a difference. Nat Struct Mol Biol 2009. 16 (12) 1209-10 Link

Dikic I, Wakatsuki S, Walters KJ Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol 2009. 10 (10) 659-71 Link

Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. Blood 2009. 114 (7) 1396-404 Link

Picuric S, Friedrich M, Oess S Expression and purification of recombinant human EGFL7 protein. Protein Expr Purif 2009. 68 (1) 1-6 Link

Schmidt MHH, Bicker F, Nikolic I, Meister J, Babuke T, Picuric S, Müller-Esterl W, Plate KH, Dikic I Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol 2009. 11 (7) 873-80 Link

Kirkin V, McEwan DG, Novak I, Dikic I A role for ubiquitin in selective autophagy. Mol Cell 2009. 34 (3) 259-69 Link

Kirkin V, Lamark T, Johansen T, Dikic I NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009. 5 (5) 732-3 Link

Dikic I Journal club. A new ubiquitin chain, a new signal. Nat Rev Mol Cell Biol 2009. 10 (5) 306 Link

Grabbe C, Dikic I Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins. Chem Rev 2009. 109 (4) 1481-94 Link

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009. 33 (4) 505-16 Link

Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. J Biol Chem 2009. 284 (5) 3183-3194 Link

Grabbe C, Dikic I Cell biology. Going global on ubiquitin. Science 2008. 322 (5903) 872-3 Link

Wiesenthal A, Hoffmeister M, Siddique M, Kovacevic I, Oess S, Müller-Esterl W, Siehoff-Icking A NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation. Traffic 2009. 10 (1) 26-34 Link

Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem 2008. 283 (50) 35173-85 Link

Beli P, Mascheroni D, Xu D, Innocenti M WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Nat Cell Biol 2008. 10 (7) 849-57 Link

Ikeda F, Dikic I Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep 2008. 9 (6) 536-42 Link

Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 2008. 453 (7194) 481-8 Link

Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 2008. 27 (26) 3739-45 Link

Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets. J Biol Chem 2008. 283 (4) 2297-306 Link

Raguz J, Wagner S, Dikic I, Hoeller D Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. FEBS Lett 2007. 581 (24) 4767-72 Link

Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 2007. 26 (14) 3451-62 Link

Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell 2007. 26 (6) 891-8 Link

Dikic I, Schmidt MHH Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. Eur J Cell Biol 2007. 86 (9) 505-12 Link

Babuke T, Tikkanen R Dissecting the molecular function of reggie/flotillin proteins. Eur J Cell Biol 2007. 86 (9) 525-32 Link

Fernow I, Icking A, Tikkanen R Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins. Eur J Cell Biol 2007. 86 (6) 345-52 Link

de Oliveira SK, Hoffmeister M, Gambaryan S, Müller-Esterl W, Guimaraes JA, Smolenski AP Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. J Biol Chem 2007. 282 (18) 13656-63 Link

Icking A, Amaddii M, Ruonala M, Höning S, Tikkanen R Polarized transport of Alzheimer amyloid precursor protein is mediated by adaptor protein complex AP1-1B. Traffic 2007. 8 (3) 285-96 Link

Kirkin V, Dikic I Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr Opin Cell Biol 2007. 19 (2) 199-205 Link

Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J Cell Sci 2007. 120 (Pt 3) 395-406 Link

Schmidt MHH, Dikic I Ubiquitin and NEDD8: brothers in arms. Sci STKE 2006. 2006 (362) .pe50 Link

Dikic I, Crosetto N, Calatroni S, Bernasconi P Targeting ubiquitin in cancers. Eur J Cancer 2006. 42 (18) 3095-102 Link

Hoeller D, Hecker CM, Dikic I Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 2006. 6 (10) 776-88 Link

Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Müller-Esterl W, Icking A Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell 2006. 17 (9) 3870-80 Link

Oess S, Icking A, Fulton D, Govers R, Müller-Esterl W Subcellular targeting and trafficking of nitric oxide synthases. Biochem J 2006. 396 (3) 401-9 Link

Ikeda F, Dikic I CYLD in ubiquitin signaling and tumor pathogenesis. Cell 2006. 125 (4) 643-5 Link

Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem 2006. 281 (23) 16117-27 Link

Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol 2006. 8 (2) 163-9 Link

Schmidt MHH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix. Oncogene 2006. 25 (21) 3071-8 Link

Icking A, Schilling K, Wiesenthal A, Opitz N, Müller-Esterl W FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. FEBS Lett 2006. 580 (1) 223-8 Link

Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005. 310 (5755) 1821-4 Link

Icking A, Matt S, Opitz N, Wiesenthal A, Müller-Esterl W, Schilling K NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci 2005. 118 (Pt 21) 5059-69 Link

Schmidt MHH, Dikic I The Cbl interactome and its functions. Nat Rev Mol Cell Biol 2005. 6 (12) 907-18 Link

Haglund K, Dikic I Ubiquitylation and cell signaling. EMBO J 2005. 24 (19) 3353-9 Link

Schleicher M, Brundin F, Gross S, Müller-Esterl W, Oess S Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. Mol Cell Biol 2005. 25 (18) 8251-8 Link

Meurer S, Pioch S, Gross S, Müller-Esterl W Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase. J Biol Chem 2005. 280 (39) 33149-56 Link

Haglund K, Schmidt MHH, Wong ES, Guy GR, Dikic I Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep 2005. 6 (7) 635-41 Link

Crosetto N, Tikkanen R, Dikic I Oncogenic breakdowns in endocytic adaptor proteins. FEBS Lett 2005. 579 (15) 3231-8 Link

Hoeller D, Volarevic S, Dikic I Compartmentalization of growth factor receptor signalling. Curr Opin Cell Biol 2005. 17 (2) 107-11 Link

Danielewski O, Schultess J, Smolenski A The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I. Thromb Haemost 2005. 93 (2) 319-25 Link

Schultess J, Danielewski O, Smolenski AP Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood 2005. 105 (8) 3185-92 Link

Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. J Biol Chem 2004. 279 (47) 49346-54 Link

Szymkiewicz I, Shupliakov O, Dikic I Cargo- and compartment-selective endocytic scaffold proteins. Biochem J 2004. 383 (Pt 1) 1-11 Link

Dikic I ALIX-ing phospholipids with endosome biogenesis. Bioessays 2004. 26 (6) 604-7 Link

Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem 2004. 279 (31) 32786-95 Link

Szymkiewicz I, Destaing O, Jurdic P, Dikic I SH3P2 in complex with Cbl and Src. FEBS Lett 2004. 565 (1-3) 33-8 Link

Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci 2004. 117 (Pt 12) 2557-68 Link

Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA, Dikic I CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell 2004. 15 (7) 3155-66 Link

Smolenski A, Schultess J, Danielewski O, Garcia Arguinzonis MI, Thalheimer P, Kneitz S, Walter U, Lohmann SM Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling. Genomics 2004. 83 (4) 577-87 Link

Höller D, Dikic I Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem Pharmacol 2004. 67 (6) 1013-7 Link

Dikic I Mechanisms controlling EGF receptor endocytosis and degradation. Biochem Soc Trans 2003. 31 (Pt 6) 1178-81 Link

Haglund K, Di Fiore PP, Dikic I Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci 2003. 28 (11) 598-603 Link

Neumann-Giesen C, Falkenbach B, Beicht P, Claasen S, Lüers G, Stuermer CA, Herzog V, Tikkanen R Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem J 2004. 378 (Pt 2) 509-18 Link

Dikic I, Szymkiewicz I, Soubeyran P Cbl signaling networks in the regulation of cell function. Cell Mol Life Sci 2003. 60 (9) 1805-27 Link

Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem 2003. 278 (41) 39735-46 Link

Zimmermann K, Opitz N, Dedio J, Renne C, Muller-Esterl W, Oess S NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 2002. 99 (26) 17167-72 Link

Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J Biol Chem 2002. 277 (46) 43623-30 Link

Renné T, Gailani D, Meijers JC, Müller-Esterl W Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J Biol Chem 2002. 277 (7) 4892-9 Link

Mailänder J, Müller-Esterl W, Dedio J Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. FEBS Lett 2001. 507 (3) 331-5 Link

Cramer H, Schmenger K, Heinrich K, Horstmeyer A, Böning H, Breit A, Piiper A, Lundstrom K, Müller-Esterl W, Schroeder C Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q. Eur J Biochem 2001. 268 (20) 5449-59 Link

Renné T, Müller-Esterl W Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. FEBS Lett 2001. 500 (1-2) 36-40 Link

Renné T, Dedio J, David G, Müller-Esterl W High molecular weight kininogen utilizes heparan sulfate proteoglycans for accumulation on endothelial cells. J Biol Chem 2000. 275 (43) 33688-96 Link

Additional publications not caught by the PubMed search string

Arkan MC. Cancer: Fat and the fate of pancreatic tumours.  Nature 2016. 536 (7615): 157-8. Link 

Voelcker G. Enzyme Catalyzed Decomposition of 4-Hydroxycyclophosphamide  The Open Conference Proceedings Journal, 2017. Link 

Voelcker G. Oxazaphosphorine cytostatics: A good way to create better is to study old oxazaphosphorines  Integrative Cancer Science and Therapeutics, 2017. Link 

Robin Krishnathas, Erik Bonke, Stefan Dröse, Volker Zickermann, and Hamid R. Nasiri. Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]-quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I  Med. Chem. Commun., 2017.  8, 657 Link 

Zickermann V. Structure and Function of Respiratory Complex I. In Mechanisms of Primary Energy Transduction in Biology. M.Wikstrom, editor. RSC Publishing,  Cambridge. 2017.  60-80; DOI 10.1039/9781788010405 Link