On this page, all publications originating from or in collaboration with IBC2 are listed. The list does not contain manuscripts which were published by an IBC2 member during a previous employment. For each individual group leader, a full publication record can be found on the respective group page.
Due to the entries in the PubMed database, until 2014 the search string only catches publications in which first or last author were IBC2-affiliated. Manuscripts published in journals not listed on PubMed are listed at the bottom of the page.

Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF Mitochondria shed their outer membrane in response to infection-induced stress. Science 2022. 375 (6577) eabi4343 Link

Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, et al. Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Nat Commun 2022. 13 (1) 281 Link

Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J, et al. Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Ann N Y Acad Sci 2022. Link

Baker F, Polat IH, Abou-El-Ardat K, Alshamleh I, Thoelken M, Hymon D, Gubas A, Koschade SE, Vischedyk JB, Kaulich M, Schwalbe H, Shaid S, Brandts CH Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3. Cancers (Basel) 2021. 13 (23) Link

Hotz PW, Müller S, Mendler L SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease. Front Mol Biosci 2021. 8 786136 Link

Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery. Mol Cell 2021. Link

Parey K, Lasham J, Mills DJ, Djurabekova A, Haapanen O, Yoga EG, Xie H, Kühlbrandt W, Sharma V, Vonck J, Zickermann V High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Sci Adv 2021. 7 (46) eabj3221 Link

Müller S Managing stress granule disassembly with ubiquitin and its cousin. Signal Transduct Target Ther 2021. 6 (1) 391 Link

Lehmann C, Pohl C A Maternal-Effect Toxin Affects Epithelial Differentiation and Tissue Mechanics in . Front Cell Dev Biol 2021. 9 743496 Link

Prieto-Garcia C, Tomašković I, Shah VJ, Dikic I, Diefenbacher M USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma. Cells 2021. 10 (10) Link

Riegel K, Yurugi H, Schlöder J, Jonuleit H, Kaulich M, Kirschner F, Arnold-Schild D, Tenzer S, Schild H, Rajalingam K ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression. Cell Death Dis 2021. 12 (11) 969 Link

Schünke H, Göbel U, Dikic I, Pasparakis M OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun 2021. 12 (1) 5912 Link

Prieto-Garcia C, Hartmann O, Reissland M, Fischer T, Maier CR, Rosenfeldt M, Schülein-Völk C, Klann K, Kalb R, Dikic I, Münch C, Diefenbacher ME Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. Cell Death Differ 2021. Link

Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, Kern A, Behl C, Bremm A The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. J Biol Chem 2021. 297 (5) 101263 Link

Russ N, Schröder M, Berger BT, Mandel S, Aydogan Y, Mauer S, Pohl C, Drewry DH, Chaikuad A, Müller S, Knapp S Design and Development of a Chemical Probe for Pseudokinase Ca/calmodulin-Dependent Ser/Thr Kinase. J Med Chem 2021. 64 (19) 14358-14376 Link

Patra U, Müller S A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity. Front Cell Dev Biol 2021. 9 696234 Link

Schmidt F, Marx A, Baumgarten N, Hebel M, Wegner M, Kaulich M, Leisegang MS, Brandes RP, Göke J, Vreeken J, Schulz MH Integrative analysis of epigenetics data identifies gene-specific regulatory elements. Nucleic Acids Res 2021. 49 (18) 10397-10418 Link

Röhm S, Berger BT, Schröder M, Chatterjee D, Mathea S, Joerger AC, Pinkas DM, Bufton JC, Tjaden A, Kovooru L, Kudolo M, Pohl C, Bullock AN, Müller S, Laufer S, Knapp S Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J Med Chem 2021. 64 (18) 13451-13474 Link

Gama-Brambila RA, Chen J, Dabiri Y, Tascher G, Němec V, Münch C, Song G, Knapp S, Cheng X A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins. JACS Au 2021. 1 (6) 777-785 Link

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, et al. Autophagy in major human diseases. EMBO J 2021. 40 (19) e108863 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Correction: Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2021. 125 (7) 1030 Link

Maculins T, Dikic I Gasdermin B in the host-pathogen tug-of-war. Cell Res 2021. 31 (10) 1043-1044 Link

Reggio A, Buonomo V, Berkane R, Bhaskara RM, Tellechea M, Peluso I, Polishchuk E, Di Lorenzo G, Cirillo C, Esposito M, Hussain A, Huebner AK, Hübner CA, Settembre C, Hummer G, Grumati P, Stolz A Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control. EMBO Rep 2021. 22 (9) e52289 Link

Gerstmeier J, Possmayer AL, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D, Linder B Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel) 2021. 13 (14) Link

Valečka J, Camosseto V, McEwan DG, Terawaki S, Liu Z, Strock E, Almeida CR, Su B, Dikic I, Liang Y, Gatti E, Pierre P RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages. R Soc Open Sci 2021. 8 (7) 202333 Link

Liu Y, Mukherjee R, Bonn F, Colby T, Matic I, Glogger M, Heilemann M, Dikic I Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection. Cell Death Differ 2021. 28 (10) 2957-2969 Link

Kaulich M, Link VM, Lapek JD, Lee YJ, Glass CK, Gonzalez DJ, Dowdy SF A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition. Sci Rep 2021. 11 (1) 14736 Link

Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P, Kulathu Y Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLoS One 2021. 16 (7) e0253364 Link

Lorenz NI, Sittig ACM, Urban H, Luger AL, Engel AL, Münch C, Steinbach JP, Ronellenfitsch MW Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide. Sci Rep 2021. 11 (1) 14161 Link

Schaefer L, Dikic I Autophagy: Instructions from the extracellular matrix. Matrix Biol 2021. 100-101 1-8 Link

Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour AR, Shin D, Khan KS, Hei-Yin Cheung H, Wong KB, Ng WL, Cinatl J, Geurink PP, van der Heden van Noort GJ, Rajalingam K, Ciesek S, Hummer G, Dikic I Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection. J Biol Chem 2021. 297 (2) 100925 Link

Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I, Kögel D BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells. J Cell Biochem 2021. Link

Körtel N, Rücklé C, Zhou Y, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J, Zarnack K Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning. Nucleic Acids Res 2021. 49 (16) e92 Link

Maculins T, Verschueren E, Hinkle T, Choi M, Chang P, Chalouni C, Rao S, Kwon Y, Lim J, Katakam AK, Kunz RC, Erickson BK, Huang T, Tsai TH, Vitek O, Reichelt M, Senbabaoglu Y, Mckenzie B, Rohde JR, Dikic I, Kirkpatrick DS, Murthy A Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response. Elife 2021. 10 Link

Kahlhöfer F, Gansen M, Zickermann V Accessory Subunits of the Matrix Arm of Mitochondrial Complex I with a Focus on Subunit NDUFS4 and Its Role in Complex I Function and Assembly. Life (Basel) 2021. 11 (5) Link

Gama-Brambila RA, Chen J, Zhou J, Tascher G, Münch C, Cheng X A PROTAC targets splicing factor 3B1. Cell Chem Biol 2021. 28 (11) 1616-1627.e8 Link

Abudu YP, Shrestha BK, Zhang W, Palara A, Brenne HB, Larsen KB, Wolfson DL, Dumitriu G, Øie CI, Ahluwalia BS, Levy G, Behrends C, Tooze SA, Mouilleron S, Lamark T, Johansen T SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. J Cell Biol 2021. 220 (8) Link

Keiten-Schmitz J, Röder L, Hornstein E, Müller-McNicoll M, Müller S SUMO: Glue or Solvent for Phase-Separated Ribonucleoprotein Complexes and Molecular Condensates? Front Mol Biosci 2021. 8 673038 Link

Galemou Yoga E, Schiller J, Zickermann V Ubiquinone Binding and Reduction by Complex I-Open Questions and Mechanistic Implications. Front Chem 2021. 9 672851 Link

Zhang H, Cao X, Tang M, Zhong G, Si Y, Li H, Zhu F, Liao Q, Li L, Zhao J, Feng J, Li S, Wang C, Kaulich M, Wang F, Chen L, Li L, Xia Z, Liang T, Lu H, Feng XH, Zhao B A subcellular map of the human kinome. Elife 2021. 10 Link

Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, Kaulich M Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res 2021. 49 (10) 5684-5704 Link

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C, Dikic I SIK2 orchestrates actin-dependent host response upon infection. Proc Natl Acad Sci U S A 2021. 118 (19) Link

Kannt A, Đikić I Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation. Cell Chem Biol 2021. 28 (7) 1014-1031 Link

Klann K, Tascher G, Münch C Virus systems biology: Proteomics profiling of dynamic protein networks during infection. Adv Virus Res 2021. 109 1-29 Link

Geßner A, Koch B, Klann K, Fuhrmann DC, Farmand S, Schubert R, Münch C, Geiger H, Baer PC Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells. Int J Mol Sci 2021. 22 (6) Link

Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol 2021. 23 (4) 413-423 Link

Gubas A, Dikic I A guide to the regulation of selective autophagy receptors. FEBS J 2022. 289 (1) 75-89 Link

Acuña-Hinrichsen F, Covarrubias-Pinto A, Ishizuka Y, Stolzenbach MF, Martin C, Salazar P, Castro MA, Bramham CR, Otth C Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines. Front Cell Neurosci 2021. 15 580717 Link

Schwich OD, Blümel N, Keller M, Wegener M, Setty ST, Brunstein ME, Poser I, Mozos IRL, Suess B, Münch C, McNicoll F, Zarnack K, Müller-McNicoll M SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Genome Biol 2021. 22 (1) 82 Link

Baumgarten N, Schmidt F, Wegner M, Hebel M, Kaulich M, Schulz MH Computational prediction of CRISPR-impaired non-coding regulatory regions. Biol Chem 2021. 402 (8) 973-982 Link

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021. 17 (1) 1-382 Link

Kunz P, Lehmann C, Pohl C Differential Thresholds of Proteasome Activation Reveal Two Separable Mechanisms of Sensory Organ Polarization in . Front Cell Dev Biol 2021. 9 619596 Link

Siggel M, Bhaskara RM, Moesser MK, D Ikić I, Hummer G FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes. J Phys Chem Lett 2021. 12 (7) 1926-1931 Link

Mende H, Müller S Surveillance of nucleolar homeostasis and ribosome maturation by autophagy and the ubiquitin-proteasome system. Matrix Biol 2021. 100-101 30-38 Link

Cetin R, Quandt E, Kaulich M Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance. Cells 2021. 10 (2) Link

Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy 2021. 17 (11) 3424-3443 Link

Herhaus L TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease. Matrix Biol 2021. 100-101 84-98 Link

Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS, McEwan DG The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Lett 2021. 595 (7) 864-880 Link

Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W DGK and DZHK position paper on genome editing: basic science applications and future perspective. Basic Res Cardiol 2021. 116 (1) 2 Link

Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I, Tan MW Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Sci Rep 2021. 11 (1) 618 Link

Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, et al. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci 2021. 22 (2) Link

Güllülü Ö, Hehlgans S, Mayer BE, Gößner I, Petraki C, Hoffmann M, Dombrowsky MJ, Kunzmann P, Hamacher K, Strebhardt K, Fokas E, Rödel C, Münch C, Rödel F A Spatial and Functional Interaction of a Heterotetramer Survivin-DNA-PKcs Complex in DNA Damage Response. Cancer Res 2021. 81 (9) 2304-2317 Link

Wiatr M, Staubach S, Figueiredo R, Stump-Guthier C, Ishikawa H, Schwerk C, Schroten H, Hanisch FG, Rudolph H, Tenenbaum T Echovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro. Microorganisms 2020. 8 (12) Link

Hotz PW, Wiesnet M, Tascher G, Braun T, Müller S, Mendler L Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury. Molecules 2020. 25 (23) Link

Galemou Yoga E, Parey K, Djurabekova A, Haapanen O, Siegmund K, Zwicker K, Sharma V, Zickermann V, Angerer H Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. Nat Commun 2020. 11 (1) 6008 Link

Shin D, Bhattacharya A, Cheng YL, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G, Dikic I Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. Elife 2020. 9 Link

Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C BAG3 Proteomic Signature under Proteostasis Stress. Cells 2020. 9 (11) Link

Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Münch C, Wass MN, Michaelis M, Cinatl J Aprotinin Inhibits SARS-CoV-2 Replication. Cells 2020. 9 (11) Link

Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kögel D, van Wijk S ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy 2021. 17 (9) 2432-2448 Link

Bremm A Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S. Sci Signal 2020. 13 (654) Link

Kim RQ, Misra M, Gonzalez A, Tomašković I, Shin D, Schindelin H, Filippov DV, Ovaa H, Đikić I, van der Heden van Noort GJ Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection. Chemistry 2021. 27 (7) 2506-2512 Link

Klann K, Münch C Unbiased translation proteomics upon cell stress. Mol Cell Oncol 2020. 7 (4) 1763150 Link

Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol Cell 2020. 80 (1) 164-174.e4 Link

Eck F, Phuyal S, Smith MD, Kaulich M, Wilkinson S, Farhan H, Behrends C ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis. J Cell Sci 2020. 133 (18) Link

McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? Diagnostics (Basel) 2020. 10 (8) Link

Han Z, Angerer H, Bischoff I, Qin Y, Stegmann D, Tuz K, Fritz G, Juarez O, Fürst R, Lashley D, Nasiri HR Concise Synthesis of 1,4-Benzoquinone-Based Natural Products as Mitochondrial Complex I Substrates and Substrate-Based Inhibitors. ChemMedChem 2020. 15 (24) 2491-2499 Link

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 2020. 587 (7835) 657-662 Link

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chem Biol 2020. 27 (11) 1441-1451.e7 Link

Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh LG, Huebner AK, Cesana M, Bonn F, Polishchuk E, Hübner CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. EMBO J 2020. 39 (17) e105696 Link

Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, Sisignano M The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. Cells 2020. 9 (7) Link

Voelcker G Aldophosphamide-thiazolidine (NSC-613060) an oxazaphosphorine cytostatic that crosses the blood brain barrier. Anticancer Drugs 2021. 32 (1) 61-65 Link

Kenny HC, Tascher G, Ziemianin A, Rudwill F, Zahariev A, Chery I, Gauquelin-Koch G, Barielle MP, Heer M, Blanc S, O'Gorman DJ, Bertile F Effectiveness of Resistive Vibration Exercise and Whey Protein Supplementation Plus Alkaline Salt on the Skeletal Muscle Proteome Following 21 Days of Bed Rest in Healthy Males. J Proteome Res 2020. 19 (8) 3438-3451 Link

Scherr J, Tang Z, Küllmer M, Balser S, Scholz AS, Winter A, Parey K, Rittner A, Grininger M, Zickermann V, Rhinow D, Terfort A, Turchanin A Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy. ACS Nano 2020. 14 (8) 9972-9978 Link

Keiten-Schmitz J, Wagner K, Piller T, Kaulich M, Alberti S, Müller S The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules. Mol Cell 2020. 79 (1) 54-67.e7 Link

Klann K, Münch C Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements. Anal Chem 2020. 92 (12) 8041-8045 Link

Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codée JDC, Filippov DV, van der Heden van Noort GJ Synthesis of Stable NAD Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC. Chembiochem 2020. 21 (20) 2903-2907 Link

Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Nature 2020. 583 (7816) 469-472 Link

Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics 2020. 21 (3) 187-203 Link

Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun 2020. 11 (1) 2039 Link

Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K ERK3/MAPK6 controls IL-8 production and chemotaxis. Elife 2020. 9 Link

Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I, Ernst A Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine. Front Cell Dev Biol 2020. 8 208 Link

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Heumüller SE, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R Author Correction: Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc 2020. 15 (6) 2140 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2020. 122 (9) 1391-1398 Link

Tiku V, Tan MW, Dikic I Mitochondrial Functions in Infection and Immunity. Trends Cell Biol 2020. 30 (4) 263-275 Link

Kliza K, Husnjak K Resolving the Complexity of Ubiquitin Networks. Front Mol Biosci 2020. 7 21 Link

Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J, Dikic I Wss1 Promotes Replication Stress Tolerance by Degrading Histones. Cell Rep 2020. 30 (9) 3117-3126.e4 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med 2020. 12 (4) e11101 Link

Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem 2020. 295 (14) 4526-4540 Link

Parey K, Wirth C, Vonck J, Zickermann V Respiratory complex I - structure, mechanism and evolution. Curr Opin Struct Biol 2020. 63 1-9 Link

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Murali A, Rajalingam K Small Rho GTPases in the control of cell shape and mobility. Cell Mol Life Sci 2014. 71 (9) 1703-21 Link

Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature 2013. 503 (7476) 422-426 Link

Camargo LL, Babelova A, Mieth A, Weigert A, Mooz J, Rajalingam K, Heide H, Wittig I, Lopes LR, Brandes RP Endo-PDI is required for TNFα-induced angiogenesis. Free Radic Biol Med 2013. 65 1398-1407 Link

Angerer H The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins. Biochem Soc Trans 2013. 41 (5) 1335-41 Link

Kmita K, Zickermann V Accessory subunits of mitochondrial complex I. Biochem Soc Trans 2013. 41 (5) 1272-9 Link

Oberoi-Khanuja TK, Murali A, Rajalingam K IAPs on the move: role of inhibitors of apoptosis proteins in cell migration. Cell Death Dis 2013. 4 e784 Link

Raman N, Nayak A, Muller S The SUMO system: a master organizer of nuclear protein assemblies. Chromosoma 2013. 122 (6) 475-85 Link

van Wijk SJ, Fiškin E, Dikic I Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors. Nat Protoc 2013. 8 (7) 1449-58 Link

Olma MH, Dikic I Cullins getting undressed by the protein exchange factor Cand1. Cell 2013. 153 (1) 14-6 Link

Fiškin E, Dikic I Parkin promotes cell survival via linear ubiquitination. EMBO J 2013. 32 (8) 1072-4 Link

Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods 2013. 10 (4) 361-5 Link

van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol Cell 2012. 47 (5) 797-809 Link

Oberoi-Khanuja TK, Rajalingam K IAPs as E3 ligases of Rac1: shaping the move. Small GTPases . 3 (2) 131-6 Link

Kovacevic I, Hu J, Siehoff-Icking A, Opitz N, Griffin A, Perkins AC, Munn AL, Müller-Esterl W, Popp R, Fleming I, Jungblut B, Hoffmeister M, Oess S The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development. EMBO J 2012. 31 (15) 3309-22 Link

Shaid S, Brandts CH, Serve H, Dikic I Ubiquitination and selective autophagy. Cell Death Differ 2013. 20 (1) 21-30 Link

Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem 2012. 287 (34) 28445-55 Link

Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. J Biol Chem 2012. 287 (28) 23626-34 Link

Ullmann R, Chien CD, Avantaggiati ML, Muller S An acetylation switch regulates SUMO-dependent protein interaction networks. Mol Cell 2012. 46 (6) 759-70 Link

Rahighi S, Dikic I Selectivity of the ubiquitin-binding modules. FEBS Lett 2012. 586 (17) 2705-10 Link

Behrends C, Fulda S Receptor proteins in selective autophagy. Int J Cell Biol 2012. 2012 673290 Link

Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J 2012. 31 (11) 2615-28 Link

Husnjak K, Dikic I Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem 2012. 81 291-322 Link

Dikic I Ivan Dikic was trained as a medical doctor at the University of Zagreb, Croatia. Curr Biol 2012. 22 (3) R76-7 Link

Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol 2012. 32 (9) 1733-44 Link

van Wijk SJ, Bienko M, Dikic I Role of UbL family modifiers and their binding proteins in cell signaling. Methods Mol Biol 2012. 832 163-71 Link

Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J 2012. 31 (1) 14-28 Link

Imre G, Larisch S, Rajalingam K Ripoptosome: a novel IAP-regulated cell death-signalling platform. J Mol Cell Biol 2011. 3 (6) 324-6 Link

van Wijk SJ, Müller S, Dikic I Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair. Genes Dev 2011. 25 (17) 1763-9 Link

Rajalingam K, Dikic I Healthy ageing through regulated proteostasis. EMBO J 2011. 30 (15) 2983-5 Link

Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 2011. 333 (6039) 228-33 Link

Behrends C, Harper JW Constructing and decoding unconventional ubiquitin chains. Nat Struct Mol Biol 2011. 18 (5) 520-8 Link

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 2011. 471 (7340) 637-41 Link

Rajalingam K, van der Goot FG When cells and microbes meet in Krakow. EMBO Rep 2011. 12 (3) 188-90 Link

McEwan DG, Dikic I The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol 2011. 21 (4) 195-201 Link

Ikeda F, Rahighi S, Wakatsuki S, Dikic I Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation. Adv Exp Med Biol 2011. 691 107-14 Link

Åkesson P, Herwald H, Rasmussen M, HÅkansson K, Abrahamson M, Hasan AAK, Schmaier AH, Müller-Esterl W, Björck L Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant. Microbiology (Reading) 2010. 156 (Pt 12) 3660-3668 Link

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, et al. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J 2010. 29 (14) 2421-32 Link

Deribe YL, Pawson T, Dikic I Post-translational modifications in signal integration. Nat Struct Mol Biol 2010. 17 (6) 666-72 Link

Dikic I, Schmidt MHH Notch: Implications of endogenous inhibitors for therapy. Bioessays 2010. 32 (6) 481-487 Link

Dikic I, Johansen T, Kirkin V Selective autophagy in cancer development and therapy. Cancer Res 2010. 70 (9) 3431-4 Link

Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell 2010. 37 (3) 396-407 Link

Wild P, Dikic I Mitochondria get a Parkin' ticket. Nat Cell Biol 2010. 12 (2) 104-6 Link

Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MHH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal 2009. 2 (102) ra84 Link

Dikic I, Dötsch V Ubiquitin linkages make a difference. Nat Struct Mol Biol 2009. 16 (12) 1209-10 Link

Dikic I, Wakatsuki S, Walters KJ Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol 2009. 10 (10) 659-71 Link

Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. Blood 2009. 114 (7) 1396-404 Link

Picuric S, Friedrich M, Oess S Expression and purification of recombinant human EGFL7 protein. Protein Expr Purif 2009. 68 (1) 1-6 Link

Schmidt MHH, Bicker F, Nikolic I, Meister J, Babuke T, Picuric S, Müller-Esterl W, Plate KH, Dikic I Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol 2009. 11 (7) 873-80 Link

Kirkin V, McEwan DG, Novak I, Dikic I A role for ubiquitin in selective autophagy. Mol Cell 2009. 34 (3) 259-69 Link

Kirkin V, Lamark T, Johansen T, Dikic I NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009. 5 (5) 732-3 Link

Dikic I Journal club. A new ubiquitin chain, a new signal. Nat Rev Mol Cell Biol 2009. 10 (5) 306 Link

Grabbe C, Dikic I Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins. Chem Rev 2009. 109 (4) 1481-94 Link

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009. 33 (4) 505-16 Link

Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. J Biol Chem 2009. 284 (5) 3183-3194 Link

Grabbe C, Dikic I Cell biology. Going global on ubiquitin. Science 2008. 322 (5903) 872-3 Link

Wiesenthal A, Hoffmeister M, Siddique M, Kovacevic I, Oess S, Müller-Esterl W, Siehoff-Icking A NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation. Traffic 2009. 10 (1) 26-34 Link

Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem 2008. 283 (50) 35173-85 Link

Beli P, Mascheroni D, Xu D, Innocenti M WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Nat Cell Biol 2008. 10 (7) 849-57 Link

Ikeda F, Dikic I Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep 2008. 9 (6) 536-42 Link

Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 2008. 453 (7194) 481-8 Link

Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 2008. 27 (26) 3739-45 Link

Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets. J Biol Chem 2008. 283 (4) 2297-306 Link

Raguz J, Wagner S, Dikic I, Hoeller D Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. FEBS Lett 2007. 581 (24) 4767-72 Link

Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 2007. 26 (14) 3451-62 Link

Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell 2007. 26 (6) 891-8 Link

Dikic I, Schmidt MHH Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. Eur J Cell Biol 2007. 86 (9) 505-12 Link

Babuke T, Tikkanen R Dissecting the molecular function of reggie/flotillin proteins. Eur J Cell Biol 2007. 86 (9) 525-32 Link

Fernow I, Icking A, Tikkanen R Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins. Eur J Cell Biol 2007. 86 (6) 345-52 Link

de Oliveira SK, Hoffmeister M, Gambaryan S, Müller-Esterl W, Guimaraes JA, Smolenski AP Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. J Biol Chem 2007. 282 (18) 13656-63 Link

Icking A, Amaddii M, Ruonala M, Höning S, Tikkanen R Polarized transport of Alzheimer amyloid precursor protein is mediated by adaptor protein complex AP1-1B. Traffic 2007. 8 (3) 285-96 Link

Kirkin V, Dikic I Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr Opin Cell Biol 2007. 19 (2) 199-205 Link

Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J Cell Sci 2007. 120 (Pt 3) 395-406 Link

Schmidt MHH, Dikic I Ubiquitin and NEDD8: brothers in arms. Sci STKE 2006. 2006 (362) .pe50 Link

Dikic I, Crosetto N, Calatroni S, Bernasconi P Targeting ubiquitin in cancers. Eur J Cancer 2006. 42 (18) 3095-102 Link

Hoeller D, Hecker CM, Dikic I Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 2006. 6 (10) 776-88 Link

Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Müller-Esterl W, Icking A Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell 2006. 17 (9) 3870-80 Link

Oess S, Icking A, Fulton D, Govers R, Müller-Esterl W Subcellular targeting and trafficking of nitric oxide synthases. Biochem J 2006. 396 (3) 401-9 Link

Ikeda F, Dikic I CYLD in ubiquitin signaling and tumor pathogenesis. Cell 2006. 125 (4) 643-5 Link

Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem 2006. 281 (23) 16117-27 Link

Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol 2006. 8 (2) 163-9 Link

Schmidt MHH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix. Oncogene 2006. 25 (21) 3071-8 Link

Icking A, Schilling K, Wiesenthal A, Opitz N, Müller-Esterl W FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. FEBS Lett 2006. 580 (1) 223-8 Link

Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005. 310 (5755) 1821-4 Link

Icking A, Matt S, Opitz N, Wiesenthal A, Müller-Esterl W, Schilling K NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci 2005. 118 (Pt 21) 5059-69 Link

Schmidt MHH, Dikic I The Cbl interactome and its functions. Nat Rev Mol Cell Biol 2005. 6 (12) 907-18 Link

Haglund K, Dikic I Ubiquitylation and cell signaling. EMBO J 2005. 24 (19) 3353-9 Link

Schleicher M, Brundin F, Gross S, Müller-Esterl W, Oess S Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. Mol Cell Biol 2005. 25 (18) 8251-8 Link

Meurer S, Pioch S, Gross S, Müller-Esterl W Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase. J Biol Chem 2005. 280 (39) 33149-56 Link

Haglund K, Schmidt MHH, Wong ES, Guy GR, Dikic I Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep 2005. 6 (7) 635-41 Link

Crosetto N, Tikkanen R, Dikic I Oncogenic breakdowns in endocytic adaptor proteins. FEBS Lett 2005. 579 (15) 3231-8 Link

Hoeller D, Volarevic S, Dikic I Compartmentalization of growth factor receptor signalling. Curr Opin Cell Biol 2005. 17 (2) 107-11 Link

Danielewski O, Schultess J, Smolenski A The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I. Thromb Haemost 2005. 93 (2) 319-25 Link

Schultess J, Danielewski O, Smolenski AP Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood 2005. 105 (8) 3185-92 Link

Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. J Biol Chem 2004. 279 (47) 49346-54 Link

Szymkiewicz I, Shupliakov O, Dikic I Cargo- and compartment-selective endocytic scaffold proteins. Biochem J 2004. 383 (Pt 1) 1-11 Link

Dikic I ALIX-ing phospholipids with endosome biogenesis. Bioessays 2004. 26 (6) 604-7 Link

Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem 2004. 279 (31) 32786-95 Link

Szymkiewicz I, Destaing O, Jurdic P, Dikic I SH3P2 in complex with Cbl and Src. FEBS Lett 2004. 565 (1-3) 33-8 Link

Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci 2004. 117 (Pt 12) 2557-68 Link

Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA, Dikic I CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell 2004. 15 (7) 3155-66 Link

Smolenski A, Schultess J, Danielewski O, Garcia Arguinzonis MI, Thalheimer P, Kneitz S, Walter U, Lohmann SM Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling. Genomics 2004. 83 (4) 577-87 Link

Höller D, Dikic I Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem Pharmacol 2004. 67 (6) 1013-7 Link

Dikic I Mechanisms controlling EGF receptor endocytosis and degradation. Biochem Soc Trans 2003. 31 (Pt 6) 1178-81 Link

Haglund K, Di Fiore PP, Dikic I Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci 2003. 28 (11) 598-603 Link

Neumann-Giesen C, Falkenbach B, Beicht P, Claasen S, Lüers G, Stuermer CA, Herzog V, Tikkanen R Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem J 2004. 378 (Pt 2) 509-18 Link

Dikic I, Szymkiewicz I, Soubeyran P Cbl signaling networks in the regulation of cell function. Cell Mol Life Sci 2003. 60 (9) 1805-27 Link

Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem 2003. 278 (41) 39735-46 Link

Zimmermann K, Opitz N, Dedio J, Renne C, Muller-Esterl W, Oess S NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 2002. 99 (26) 17167-72 Link

Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J Biol Chem 2002. 277 (46) 43623-30 Link

Renné T, Gailani D, Meijers JC, Müller-Esterl W Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J Biol Chem 2002. 277 (7) 4892-9 Link

Mailänder J, Müller-Esterl W, Dedio J Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. FEBS Lett 2001. 507 (3) 331-5 Link

Cramer H, Schmenger K, Heinrich K, Horstmeyer A, Böning H, Breit A, Piiper A, Lundstrom K, Müller-Esterl W, Schroeder C Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q. Eur J Biochem 2001. 268 (20) 5449-59 Link

Renné T, Müller-Esterl W Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. FEBS Lett 2001. 500 (1-2) 36-40 Link

Renné T, Dedio J, David G, Müller-Esterl W High molecular weight kininogen utilizes heparan sulfate proteoglycans for accumulation on endothelial cells. J Biol Chem 2000. 275 (43) 33688-96 Link

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