On this page, all publications originating from or in collaboration with IBC2 are listed. The list does not contain manuscripts which were published by an IBC2 member during a previous employment. For each individual group leader, a full publication record can be found on the respective group page.
Due to the entries in the PubMed database, until 2014 the search string only catches publications in which first or last author were IBC2-affiliated. Manuscripts published in journals not listed on PubMed are listed at the bottom of the page.

Geßner A, Koch B, Klann K, Fuhrmann DC, Farmand S, Schubert R, Münch C, Geiger H, Baer PC Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells. Int J Mol Sci 2021. 22 (6) Link

Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol 2021. 23 (4) 413-423 Link

Gubas A, Dikic I A Guide To… The regulation of selective autophagy receptors. FEBS J 2021. Link

Acuña-Hinrichsen F, Covarrubias-Pinto A, Ishizuka Y, Stolzenbach MF, Martin C, Salazar P, Castro MA, Bramham CR, Otth C Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines. Front Cell Neurosci 2021. 15 580717 Link

Schwich OD, Blümel N, Keller M, Wegener M, Setty ST, Brunstein ME, Poser I, Mozos IRL, Suess B, Münch C, McNicoll F, Zarnack K, Müller-McNicoll M SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Genome Biol 2021. 22 (1) 82 Link

Baumgarten N, Schmidt F, Wegner M, Hebel M, Kaulich M, Schulz MH Computational prediction of CRISPR-impaired non-coding regulatory regions. Biol Chem 2021. Link

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021. 17 (1) 1-382 Link

Kunz P, Lehmann C, Pohl C Differential Thresholds of Proteasome Activation Reveal Two Separable Mechanisms of Sensory Organ Polarization in . Front Cell Dev Biol 2021. 9 619596 Link

Siggel M, Bhaskara RM, Moesser MK, D Ikić I, Hummer G FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes. J Phys Chem Lett 2021. 12 (7) 1926-1931 Link

Mende H, Müller S Surveillance of nucleolar homeostasis and ribosome maturation by autophagy and the ubiquitin-proteasome system. Matrix Biol 2021. Link

Cetin R, Quandt E, Kaulich M Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance. Cells 2021. 10 (2) Link

Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy 2021. 1-20 Link

Herhaus L TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease. Matrix Biol 2021. Link

Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS, McEwan DG The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Lett 2021. 595 (7) 864-880 Link

Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W DGK and DZHK position paper on genome editing: basic science applications and future perspective. Basic Res Cardiol 2021. 116 (1) 2 Link

Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I, Tan MW Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Sci Rep 2021. 11 (1) 618 Link

Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, et al. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci 2021. 22 (2) Link

Güllülü Ö, Hehlgans S, Mayer BE, Gößner I, Petraki C, Hoffmann M, Dombrowsky MJ, Kunzmann P, Hamacher K, Strebhardt K, Fokas E, Rödel C, Münch C, Rödel F A spatial and functional interaction of a heterotetramer Survivin-DNA-PKcs complex in DNA damage response. Cancer Res 2021. Link

Wiatr M, Staubach S, Figueiredo R, Stump-Guthier C, Ishikawa H, Schwerk C, Schroten H, Hanisch FG, Rudolph H, Tenenbaum T Echovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro. Microorganisms 2020. 8 (12) Link

Hotz PW, Wiesnet M, Tascher G, Braun T, Müller S, Mendler L Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury. Molecules 2020. 25 (23) Link

Galemou Yoga E, Parey K, Djurabekova A, Haapanen O, Siegmund K, Zwicker K, Sharma V, Zickermann V, Angerer H Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. Nat Commun 2020. 11 (1) 6008 Link

Shin D, Bhattacharya A, Cheng YL, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G, Dikic I Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. Elife 2020. 9 Link

Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C BAG3 Proteomic Signature under Proteostasis Stress. Cells 2020. 9 (11) Link

Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Münch C, Wass MN, Michaelis M, Cinatl J Aprotinin Inhibits SARS-CoV-2 Replication. Cells 2020. 9 (11) Link

Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kögel D, van Wijk S ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy 2020. 1-17 Link

Bremm A Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S. Sci Signal 2020. 13 (654) Link

Kim RQ, Misra M, Gonzalez A, Tomašković I, Shin D, Schindelin H, Filippov DV, Ovaa H, Đikić I, van der Heden van Noort GJ Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection. Chemistry 2021. 27 (7) 2506-2512 Link

Klann K, Münch C Unbiased translation proteomics upon cell stress. Mol Cell Oncol 2020. 7 (4) 1763150 Link

Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol Cell 2020. 80 (1) 164-174.e4 Link

Eck F, Phuyal S, Smith MD, Kaulich M, Wilkinson S, Farhan H, Behrends C ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis. J Cell Sci 2020. 133 (18) Link

McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? Diagnostics (Basel) 2020. 10 (8) Link

Han Z, Angerer H, Bischoff I, Qin Y, Stegmann D, Tuz K, Fritz G, Juarez O, Fürst R, Lashley D, Nasiri HR Concise Synthesis of 1,4-Benzoquinone-Based Natural Products as Mitochondrial Complex I Substrates and Substrate-Based Inhibitors. ChemMedChem 2020. 15 (24) 2491-2499 Link

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 2020. 587 (7835) 657-662 Link

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chem Biol 2020. 27 (11) 1441-1451.e7 Link

Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh LG, Huebner AK, Cesana M, Bonn F, Polishchuk E, Hübner CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. EMBO J 2020. 39 (17) e105696 Link

Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, Sisignano M The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. Cells 2020. 9 (7) Link

Voelcker G Aldophosphamide-thiazolidine (NSC-613060) an oxazaphosphorine cytostatic that crosses the blood brain barrier. Anticancer Drugs 2021. 32 (1) 61-65 Link

Kenny HC, Tascher G, Ziemianin A, Rudwill F, Zahariev A, Chery I, Gauquelin-Koch G, Barielle MP, Heer M, Blanc S, O'Gorman DJ, Bertile F Effectiveness of Resistive Vibration Exercise and Whey Protein Supplementation Plus Alkaline Salt on the Skeletal Muscle Proteome Following 21 Days of Bed Rest in Healthy Males. J Proteome Res 2020. 19 (8) 3438-3451 Link

Scherr J, Tang Z, Küllmer M, Balser S, Scholz AS, Winter A, Parey K, Rittner A, Grininger M, Zickermann V, Rhinow D, Terfort A, Turchanin A Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy. ACS Nano 2020. 14 (8) 9972-9978 Link

Keiten-Schmitz J, Wagner K, Piller T, Kaulich M, Alberti S, Müller S The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules. Mol Cell 2020. 79 (1) 54-67.e7 Link

Klann K, Münch C Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements. Anal Chem 2020. 92 (12) 8041-8045 Link

Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codée JDC, Filippov DV, van der Heden van Noort GJ Synthesis of Stable NAD Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC. Chembiochem 2020. 21 (20) 2903-2907 Link

Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Nature 2020. 583 (7816) 469-472 Link

Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics 2020. 21 (3) 187-203 Link

Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun 2020. 11 (1) 2039 Link

Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K ERK3/MAPK6 controls IL-8 production and chemotaxis. Elife 2020. 9 Link

Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I, Ernst A Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine. Front Cell Dev Biol 2020. 8 208 Link

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Heumüller SE, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R Author Correction: Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc 2020. 15 (6) 2140 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2020. 122 (9) 1391-1398 Link

Tiku V, Tan MW, Dikic I Mitochondrial Functions in Infection and Immunity. Trends Cell Biol 2020. 30 (4) 263-275 Link

Kliza K, Husnjak K Resolving the Complexity of Ubiquitin Networks. Front Mol Biosci 2020. 7 21 Link

Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J, Dikic I Wss1 Promotes Replication Stress Tolerance by Degrading Histones. Cell Rep 2020. 30 (9) 3117-3126.e4 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med 2020. 12 (4) e11101 Link

Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem 2020. 295 (14) 4526-4540 Link

Parey K, Wirth C, Vonck J, Zickermann V Respiratory complex I - structure, mechanism and evolution. Curr Opin Struct Biol 2020. 63 1-9 Link

Voelcker G Causes and possibilities to circumvent cyclophosphamide toxicity. Anticancer Drugs 2020. 31 (6) 617-622 Link

Biederstädt A, Hassan Z, Schneeweis C, Schick M, Schneider L, Muckenhuber A, Hong Y, Siegers G, Nilsson L, Wirth M, Dantes Z, Steiger K, Schunck K, Langston S, Lenhof HP, Coluccio A, Orben F, Slawska J, Scherger A, Saur D, Müller S, Rad R, Weichert W, Nilsson J, Reichert M, et al. SUMO pathway inhibition targets an aggressive pancreatic cancer subtype. Gut 2020. 69 (8) 1472-1482 Link

Keiten-Schmitz J, Schunck K, Müller S SUMO Chains Rule on Chromatin Occupancy. Front Cell Dev Biol 2019. 7 343 Link

Hannig J, Schäfer H, Ackermann J, Hebel M, Schäfer T, Döring C, Hartmann S, Hansmann ML, Koch I Bioinformatics analysis of whole slide images reveals significant neighborhood preferences of tumor cells in Hodgkin lymphoma. PLoS Comput Biol 2020. 16 (1) e1007516 Link

Mader J, Huber J, Bonn F, Dötsch V, Rogov VV, Bremm A Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. J Biol Chem 2020. 295 (8) 2160-2174 Link

Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I, Heilemann M Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells. Sci Signal 2020. 13 (614) Link

Galemou Yoga E, Angerer H, Parey K, Zickermann V Respiratory complex I - Mechanistic insights and advances in structure determination. Biochim Biophys Acta Bioenerg 2020. 1861 (3) 148153 Link

Wegner M, Husnjak K, Kaulich M Unbiased and Tailored CRISPR/Cas gRNA Libraries by SynthesizingCovalently-closed-circular (3Cs) DNA. Bio Protoc 2020. 10 (1) e3472 Link

Parey K, Haapanen O, Sharma V, Köfeler H, Züllig T, Prinz S, Siegmund K, Wittig I, Mills DJ, Vonck J, Kühlbrandt W, Zickermann V High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Sci Adv 2019. 5 (12) eaax9484 Link

Klann K, Tascher G, Münch C Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α. Mol Cell 2020. 77 (4) 913-925.e4 Link

Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Mol Cell 2020. 77 (1) 164-179.e6 Link

Pohl C, Dikic I Cellular quality control by the ubiquitin-proteasome system and autophagy. Science 2019. 366 (6467) 818-822 Link

Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease. EMBO Rep 2020. 21 (1) e48317 Link

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Elisabeth Heumüller S, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc 2019. 14 (12) 3395-3425 Link

Hübner CA, Dikic I ER-phagy and human diseases. Cell Death Differ 2020. 27 (3) 833-842 Link

Dutta P, Odedra D, Pohl C Planar Asymmetries in the Embryo Emerge by Differential Retention of aPARs at Cell-Cell Contacts. Front Cell Dev Biol 2019. 7 209 Link

Buchbender A, Mutter H, Sutandy FXR, Körtel N, Hänel H, Busch A, Ebersberger S, König J Improved library preparation with the new iCLIP2 protocol. Methods 2020. 178 33-48 Link

Wagner K, Kunz K, Piller T, Tascher G, Hölper S, Stehmeier P, Keiten-Schmitz J, Schick M, Keller U, Müller S The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics. Cell Rep 2019. 29 (2) 480-494.e5 Link

Pitzius S, Osterburg C, Gebel J, Tascher G, Schäfer B, Zhou H, Münch C, Dötsch V TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain. Cell Death Dis 2019. 10 (10) 686 Link

Singh D, Odedra D, Dutta P, Pohl C Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis. J Cell Sci 2019. 132 (19) Link

Stolz A, Grumati P The various shades of ER-phagy. FEBS J 2019. 286 (23) 4642-4649 Link

Hoock SC, Ritter A, Steinhäuser K, Roth S, Behrends C, Oswald F, Solbach C, Louwen F, Kreis NN, Yuan J RITA modulates cell migration and invasion by affecting focal adhesion dynamics. Mol Oncol 2019. 13 (10) 2121-2141 Link

Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease. Ann Neurol 2019. 86 (4) 593-606 Link

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. Nature 2019. 572 (7769) 382-386 Link

Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy. Biochim Biophys Acta Mol Cell Res 2019. 1866 (10) 1556-1566 Link

Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nat Microbiol 2019. 4 (9) 1516-1531 Link

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J Mol Biol 2019. 431 (17) 3146-3156 Link

Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics. Biochim Biophys Acta Bioenerg 2019. 1860 (7) 573-581 Link

Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy. Nat Commun 2019. 10 (1) 2370 Link

Scherr J, Neuhaus A, Parey K, Klusch N, Murphy BJ, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy. ACS Nano 2019. 13 (6) 7185-7190 Link

Mukherjee R, Dikic I NIPSNAP Beacons in Mitophagy. Dev Cell 2019. 49 (4) 503-505 Link

Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunz K, Hoelper S, Zia-Chahabi S, Jabagi MJ, Emmerich J, Dray-Spira R, Kuhlee F, Hackmann K, Schroeck E, Wenzel P, Müller S, Filmann N, Fontenay M, Pajevic PD, Krause DS Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis. Blood 2019. 134 (3) 227-238 Link

Misra M, Dikic I RNA binding to p62 impacts selective autophagy. Cell Res 2019. 29 (7) 512-513 Link

Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5. Autophagy 2020. 16 (2) 256-270 Link

Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J 2019. 38 (10) Link

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science 2019. 364 (6436) 188-193 Link

Tiku V, Dikic I Autophagy without conjugation. Nat Struct Mol Biol 2019. 26 (4) 249-250 Link

Graab P, Bock C, Weiss K, Hirth A, Koller N, Braner M, Jung J, Loehr F, Tampé R, Behrends C, Abele R Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues. J Biol Chem 2019. 294 (18) 7308-7323 Link

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling. Cancers (Basel) 2019. 11 (3) Link

Voelcker G Oxazaphosphorine cytostatics: from serendipity to rational drug design. Anticancer Drugs 2019. 30 (5) 435-440 Link

Kunz K, Müller S, Mendler L Assays of SUMO protease/isopeptidase activity and function in mammalian cells and tissues. Methods Enzymol 2019. 618 389-410 Link

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife 2019. 8 Link

Bencsik P, Kiss K, Ágg B, Baán JA, Ágoston G, Varga A, Gömöri K, Mendler L, Faragó N, Zvara Á, Sántha P, Puskás LG, Jancsó G, Ferdinandy P Sensory Neuropathy Affects Cardiac miRNA Expression Network Targeting , , , and mRNAs. Int J Mol Sci 2019. 20 (4) Link

Tascher G, Burban A, Camus S, Plumel M, Chanon S, Le Guevel R, Shevchenko V, Van Dorsselaer A, Lefai E, Guguen-Guillouzo C, Bertile F In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes. Cells 2019. 8 (2) Link

Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif. Protein Sci 2019. 28 (5) 848-856 Link

Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem J 2019. 476 (5) 875-887 Link

Fottner M, Brunner AD, Bittl V, Horn-Ghetko D, Jussupow A, Kaila VRI, Bremm A, Lang K Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase. Nat Chem Biol 2019. 15 (3) 276-284 Link

Key J, Mueller AK, Gispert S, Matschke L, Wittig I, Corti O, Münch C, Decher N, Auburger G Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol Dis 2019. 127 114-130 Link

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Olma MH, Dikic I Cullins getting undressed by the protein exchange factor Cand1. Cell 2013. 153 (1) 14-6 Link

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Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem 2012. 287 (34) 28445-55 Link

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Rajalingam K, van der Goot FG When cells and microbes meet in Krakow. EMBO Rep 2011. 12 (3) 188-90 Link

McEwan DG, Dikic I The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol 2011. 21 (4) 195-201 Link

Ikeda F, Rahighi S, Wakatsuki S, Dikic I Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation. Adv Exp Med Biol 2011. 691 107-14 Link

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Dikic I, Schmidt MHH Notch: Implications of endogenous inhibitors for therapy. Bioessays 2010. 32 (6) 481-487 Link

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Wild P, Dikic I Mitochondria get a Parkin' ticket. Nat Cell Biol 2010. 12 (2) 104-6 Link

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Dikic I Journal club. A new ubiquitin chain, a new signal. Nat Rev Mol Cell Biol 2009. 10 (5) 306 Link

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Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 2008. 27 (26) 3739-45 Link

Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets. J Biol Chem 2008. 283 (4) 2297-306 Link

Raguz J, Wagner S, Dikic I, Hoeller D Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. FEBS Lett 2007. 581 (24) 4767-72 Link

Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 2007. 26 (14) 3451-62 Link

Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell 2007. 26 (6) 891-8 Link

Dikic I, Schmidt MHH Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. Eur J Cell Biol 2007. 86 (9) 505-12 Link

Babuke T, Tikkanen R Dissecting the molecular function of reggie/flotillin proteins. Eur J Cell Biol 2007. 86 (9) 525-32 Link

Fernow I, Icking A, Tikkanen R Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins. Eur J Cell Biol 2007. 86 (6) 345-52 Link

de Oliveira SK, Hoffmeister M, Gambaryan S, Müller-Esterl W, Guimaraes JA, Smolenski AP Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. J Biol Chem 2007. 282 (18) 13656-63 Link

Icking A, Amaddii M, Ruonala M, Höning S, Tikkanen R Polarized transport of Alzheimer amyloid precursor protein is mediated by adaptor protein complex AP1-1B. Traffic 2007. 8 (3) 285-96 Link

Kirkin V, Dikic I Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr Opin Cell Biol 2007. 19 (2) 199-205 Link

Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J Cell Sci 2007. 120 (Pt 3) 395-406 Link

Schmidt MHH, Dikic I Ubiquitin and NEDD8: brothers in arms. Sci STKE 2006. 2006 (362) .pe50 Link

Dikic I, Crosetto N, Calatroni S, Bernasconi P Targeting ubiquitin in cancers. Eur J Cancer 2006. 42 (18) 3095-102 Link

Hoeller D, Hecker CM, Dikic I Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 2006. 6 (10) 776-88 Link

Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Müller-Esterl W, Icking A Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell 2006. 17 (9) 3870-80 Link

Oess S, Icking A, Fulton D, Govers R, Müller-Esterl W Subcellular targeting and trafficking of nitric oxide synthases. Biochem J 2006. 396 (3) 401-9 Link

Ikeda F, Dikic I CYLD in ubiquitin signaling and tumor pathogenesis. Cell 2006. 125 (4) 643-5 Link

Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem 2006. 281 (23) 16117-27 Link

Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol 2006. 8 (2) 163-9 Link

Schmidt MHH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix. Oncogene 2006. 25 (21) 3071-8 Link

Icking A, Schilling K, Wiesenthal A, Opitz N, Müller-Esterl W FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. FEBS Lett 2006. 580 (1) 223-8 Link

Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005. 310 (5755) 1821-4 Link

Icking A, Matt S, Opitz N, Wiesenthal A, Müller-Esterl W, Schilling K NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci 2005. 118 (Pt 21) 5059-69 Link

Schmidt MHH, Dikic I The Cbl interactome and its functions. Nat Rev Mol Cell Biol 2005. 6 (12) 907-18 Link

Haglund K, Dikic I Ubiquitylation and cell signaling. EMBO J 2005. 24 (19) 3353-9 Link

Schleicher M, Brundin F, Gross S, Müller-Esterl W, Oess S Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. Mol Cell Biol 2005. 25 (18) 8251-8 Link

Meurer S, Pioch S, Gross S, Müller-Esterl W Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase. J Biol Chem 2005. 280 (39) 33149-56 Link

Haglund K, Schmidt MHH, Wong ES, Guy GR, Dikic I Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep 2005. 6 (7) 635-41 Link

Crosetto N, Tikkanen R, Dikic I Oncogenic breakdowns in endocytic adaptor proteins. FEBS Lett 2005. 579 (15) 3231-8 Link

Hoeller D, Volarevic S, Dikic I Compartmentalization of growth factor receptor signalling. Curr Opin Cell Biol 2005. 17 (2) 107-11 Link

Danielewski O, Schultess J, Smolenski A The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I. Thromb Haemost 2005. 93 (2) 319-25 Link

Schultess J, Danielewski O, Smolenski AP Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood 2005. 105 (8) 3185-92 Link

Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. J Biol Chem 2004. 279 (47) 49346-54 Link

Szymkiewicz I, Shupliakov O, Dikic I Cargo- and compartment-selective endocytic scaffold proteins. Biochem J 2004. 383 (Pt 1) 1-11 Link

Dikic I ALIX-ing phospholipids with endosome biogenesis. Bioessays 2004. 26 (6) 604-7 Link

Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem 2004. 279 (31) 32786-95 Link

Szymkiewicz I, Destaing O, Jurdic P, Dikic I SH3P2 in complex with Cbl and Src. FEBS Lett 2004. 565 (1-3) 33-8 Link

Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci 2004. 117 (Pt 12) 2557-68 Link

Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA, Dikic I CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell 2004. 15 (7) 3155-66 Link

Smolenski A, Schultess J, Danielewski O, Garcia Arguinzonis MI, Thalheimer P, Kneitz S, Walter U, Lohmann SM Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling. Genomics 2004. 83 (4) 577-87 Link

Höller D, Dikic I Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem Pharmacol 2004. 67 (6) 1013-7 Link

Dikic I Mechanisms controlling EGF receptor endocytosis and degradation. Biochem Soc Trans 2003. 31 (Pt 6) 1178-81 Link

Haglund K, Di Fiore PP, Dikic I Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci 2003. 28 (11) 598-603 Link

Neumann-Giesen C, Falkenbach B, Beicht P, Claasen S, Lüers G, Stuermer CA, Herzog V, Tikkanen R Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem J 2004. 378 (Pt 2) 509-18 Link

Dikic I, Szymkiewicz I, Soubeyran P Cbl signaling networks in the regulation of cell function. Cell Mol Life Sci 2003. 60 (9) 1805-27 Link

Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem 2003. 278 (41) 39735-46 Link

Zimmermann K, Opitz N, Dedio J, Renne C, Muller-Esterl W, Oess S NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 2002. 99 (26) 17167-72 Link

Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J Biol Chem 2002. 277 (46) 43623-30 Link

Renné T, Gailani D, Meijers JC, Müller-Esterl W Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J Biol Chem 2002. 277 (7) 4892-9 Link

Mailänder J, Müller-Esterl W, Dedio J Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. FEBS Lett 2001. 507 (3) 331-5 Link

Cramer H, Schmenger K, Heinrich K, Horstmeyer A, Böning H, Breit A, Piiper A, Lundstrom K, Müller-Esterl W, Schroeder C Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q. Eur J Biochem 2001. 268 (20) 5449-59 Link

Renné T, Müller-Esterl W Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. FEBS Lett 2001. 500 (1-2) 36-40 Link

Renné T, Dedio J, David G, Müller-Esterl W High molecular weight kininogen utilizes heparan sulfate proteoglycans for accumulation on endothelial cells. J Biol Chem 2000. 275 (43) 33688-96 Link

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Voelcker G. Enzyme Catalyzed Decomposition of 4-Hydroxycyclophosphamide  The Open Conference Proceedings Journal, 2017. Link 

Voelcker G. Oxazaphosphorine cytostatics: A good way to create better is to study old oxazaphosphorines  Integrative Cancer Science and Therapeutics, 2017. Link 

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Zickermann V. Structure and Function of Respiratory Complex I. In Mechanisms of Primary Energy Transduction in Biology. M.Wikstrom, editor. RSC Publishing,  Cambridge. 2017.  60-80; DOI 10.1039/9781788010405 Link