Pauline was born in France, studied Pharmacy in Paris, and completed her PhD at the University of Oxford. During her doctoral work she investigated how the selective autophagy receptor TEX264 mediates nucleophagy and participates in DNA-damage response. Her work culminated in a first-author publication in Cell in 2024, highlighting a previously unrecognized link between nuclear protein clearance and genome maintenance.

Since moving to Frankfurt as a postdoctoral researcher at Goethe University Frankfurt, Pauline now focuses on an IRGQ-driven project exploring how quality-control pathways coordinate cytoplasmic proteostasis under stress conditions. She is particularly interested in dissecting the molecular mechanisms that maintain immune recognition, how their dysregulation contributes to disease, and how fundamental cell-biology insights can be translated into therapeutically relevant knowledge.

Pauline’s overall goal is to bridge basic mechanistic understanding with translational relevance — combining cell biology, autophagy, DNA-damage repair and proteostasis to shed light on disease-relevant pathways.