Conferences and Workshops

24. Mar 2025
Location: March 24-27, 2025
Campus Westend
Goethe University Frankfurt am Main
Germany
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4th Frankfurt Conference on Quality Control in Life Processes
The 4th Frankfurt Conference on Quality Control in Life Processes,
organized by SFB1177 and ENABLE, is taking place March 24-27, 2025 at Goethe University Frankfurt.
The meeting brings together scientists from all career stages to discuss mechanisms of cellular homeostasis and their impact on the pathogenesis of major human diseases.
More information can be found here: www.FCQC.de
05. Dec 2024
Location: December, 5-6, 2024
Campus Westend
Goethe University
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Info and registration
More information can be found here.
Leiden University Medical Center
26. Nov 2024 17:00h
Location: Lecture Hall H22-2, Bldg. 22, Campus Niederrad, GU Frankfurt
Hybrid Lecture
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Intracellular vesicles like lysosomes move bidirectionally and in a stop-and-go fashion along microtubules. This involves the activities of two motor types; the dynein-dynactin motor complex for inward and the kinesin motors for outward transport. We considered this transport in the context of living cells using endogenously tagged fluorescent proteins. We show how the perinuclear cloud of lysosomes is positioned and how the mobile pool of lysosomes surf on the surface of the ER while moving along microtubules. The motor proteins utilize anchors on the lysosomal membrane for binding. By quantifying the different components in this system, motor binding appears to be the limiting factor. In fact, movement is not controlled by the number of motors on a vesicle but by their activation, a process controlled by microtubule-associated proteins. The activated dynein-dynactin motor is assembled at the growing microtubule plus end and then moves inward to be intercepted by Rab7-RILP on lysosomes for lysosomal inward movement. The kinesin motor is activated at various sites along microtubules. We present a new model explaining bidirectional transport of lysosomes by considering these in the context of living cells.
University Hospital Frankfurt
05. Nov 2024 16:00h
Location: On-site:
University Hospital, Goethe University, Bldg. 75, ground floor, seminar room
Hybrid Lecture
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