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Welcome to the

Münch lab

We are a international, multidisciplinary team focusing on the molecular mechanisms of life. Applying a combination of systems biology, biochemistry and molecular biology, we examine how stress responses shape cellular behavior and pathology. Our team consists of biochemists, physicians, pharmacists, bioinformaticians and biologists. Based in the collaborative environment of Frankfurt we strive to discover the big picture of biology.

Our Research

To find out more click on one of the main topics or directly explore the detailed projects:

Proteostasis

mtUPR

Autophagy / Mitophagy

Cellular Stress Responses

Molecular Systems Biology & Medicine

Systems Medicine

Quantitative Proteomics

Software

Selected Publications

(first/last author publications)

Sutandy FXR, Gößner I et al. "A cytosolic surveillance mechanism activates the mitochondrial UPR" Nature 2023

Metzler M, Tharyan RG et al. "SARS-CoV-2 variants show different host cell proteome profiles with delayed immune response activation in Omicron-infected cells" Mol Cell Proteomics 2023

Michaelis JB et al. "Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy" Nature Communications 2022

Koschade SE et al. "Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia" Leukemia 2022

Schäfer JA, Bozkurt S, Michaelis JB et al. "Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery" Molecular Cell 2022

Klann K, Münch C "PBLMM: Peptide-based linear mixed models for differential expression analysis of shotgun proteomics data" J Cell Biochem 2022

Kohli A, Sauerhering L, Fehling SK, Klann K, Geiger H, Becker S, Koch B, Baer PC, Strecker T, Münch C "Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells" Life Sci Alliance 2022

Bojkova D, Klann K, Koch B et al. "Proteomics of SARS-CoV-2-infected host cells reveals therapy targets" Nature 2020 583, 469–472

Klann K, Bojkova D et al. "Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication" Molecular Cell 2020. 80 (1) 164-174.e4

Klann K et al. "Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α" Molecular Cell 2020, 77(4), 913-925.e4

Klann K et al. "Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements" Analytical Chemistry 2020, 92, 12, 8041-8045

Münch C and Harper JW "Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation" Nature 2016, 534 (7609) 710-3

All Publications

Publications from PubMed: 0


Our Funding

European Research Council
Emmy Noether-Programm der DFG
Bundesministerium für Bildung und Forschung
Else Kröner Fresenius Stiftung
LOEWE Exzellenzinitative des Landes Hessen
SFB1177 - Autophagy
LOEWE Zentrum für Zell- und Gentherapie Frankfurt
Cardio Pulmonary Institute Frankfurt
ENABLE Frankfurt
Proxidrugs
Aventis Foundation
Johanna Quandt Young Academy
EMBO Young Investigator Programme
Fraunhofer Innovation Center
SFB1531