Welcome to the

Münch lab

We are a international, multidisciplinary team focusing on the molecular mechanisms of life. Applying a combination of systems biology, biochemistry and molecular biology, we examine how stress responses shape cellular behavior and pathology. Our team consists of biochemists, physicians, bioinformaticians and biologists. Based in the collaborative environment of Frankfurt we strive to discover the big picture of biology.

Selected Publications

Bojkova, D., Klann, K., Koch, B. et al. "Proteomics of SARS-CoV-2-infected host cells reveals therapy targets" Nature 2020 583, 469–472

Klann K, Bojkova D et al. "Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication" Molecular Cell 2020. 80 (1) 164-174.e4

Klann et al. "Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α" Molecular Cell 2020, 77(4), 913-925.e4

Klann et al. "Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements" Analytical Chemistry 2020, 92, 12, 8041-8045

Münch and Harper "Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation" Nature 2016, 534 (7609) 710-3

All Publications

Publications from PubMed: 45


Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery. Mol Cell 2021. Link

Prieto-Garcia C, Hartmann O, Reissland M, Fischer T, Maier CR, Rosenfeldt M, Schülein-Völk C, Klann K, Kalb R, Dikic I, Münch C, Diefenbacher ME Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. Cell Death Differ 2021. Link

Gama-Brambila RA, Chen J, Dabiri Y, Tascher G, Němec V, Münch C, Song G, Knapp S, Cheng X A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins. JACS Au 2021. 1 (6) 777-785 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Correction: Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2021. 125 (7) 1030 Link

Gerstmeier J, Possmayer AL, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D, Linder B Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel) 2021. 13 (14) Link

Lorenz NI, Sittig ACM, Urban H, Luger AL, Engel AL, Münch C, Steinbach JP, Ronellenfitsch MW Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide. Sci Rep 2021. 11 (1) 14161 Link

Gama-Brambila RA, Chen J, Zhou J, Tascher G, Münch C, Cheng X A PROTAC targets splicing factor 3B1. Cell Chem Biol 2021. 28 (11) 1616-1627.e8 Link

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C, Dikic I SIK2 orchestrates actin-dependent host response upon infection. Proc Natl Acad Sci U S A 2021. 118 (19) Link

Klann K, Tascher G, Münch C Virus systems biology: Proteomics profiling of dynamic protein networks during infection. Adv Virus Res 2021. 109 1-29 Link

Geßner A, Koch B, Klann K, Fuhrmann DC, Farmand S, Schubert R, Münch C, Geiger H, Baer PC Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells. Int J Mol Sci 2021. 22 (6) Link

Schwich OD, Blümel N, Keller M, Wegener M, Setty ST, Brunstein ME, Poser I, Mozos IRL, Suess B, Münch C, McNicoll F, Zarnack K, Müller-McNicoll M SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Genome Biol 2021. 22 (1) 82 Link

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021. 17 (1) 1-382 Link

Klann K, Münch C Biospektrum (Heidelb) 2021. 27 (1) 40-45 Link

Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy 2021. 1-20 Link

Güllülü Ö, Hehlgans S, Mayer BE, Gößner I, Petraki C, Hoffmann M, Dombrowsky MJ, Kunzmann P, Hamacher K, Strebhardt K, Fokas E, Rödel C, Münch C, Rödel F A Spatial and Functional Interaction of a Heterotetramer Survivin-DNA-PKcs Complex in DNA Damage Response. Cancer Res 2021. 81 (9) 2304-2317 Link

Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C BAG3 Proteomic Signature under Proteostasis Stress. Cells 2020. 9 (11) Link

Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Münch C, Wass MN, Michaelis M, Cinatl J Aprotinin Inhibits SARS-CoV-2 Replication. Cells 2020. 9 (11) Link

Klann K, Münch C Unbiased translation proteomics upon cell stress. Mol Cell Oncol 2020. 7 (4) 1763150 Link

Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol Cell 2020. 80 (1) 164-174.e4 Link

McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? Diagnostics (Basel) 2020. 10 (8) Link

Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, Sisignano M The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. Cells 2020. 9 (7) Link

Klann K, Münch C Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements. Anal Chem 2020. 92 (12) 8041-8045 Link

Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Nature 2020. 583 (7816) 469-472 Link

Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics 2020. 21 (3) 187-203 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2020. 122 (9) 1391-1398 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med 2020. 12 (4) e11101 Link

Klann K, Tascher G, Münch C Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α. Mol Cell 2020. 77 (4) 913-925.e4 Link

Pitzius S, Osterburg C, Gebel J, Tascher G, Schäfer B, Zhou H, Münch C, Dötsch V TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain. Cell Death Dis 2019. 10 (10) 686 Link

Key J, Mueller AK, Gispert S, Matschke L, Wittig I, Corti O, Münch C, Decher N, Auburger G Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol Dis 2019. 127 114-130 Link

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int 2019. 95 (3) 540-562 Link

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood 2019. 133 (2) 168-179 Link

Münch C The different axes of the mammalian mitochondrial unfolded protein response. BMC Biol 2018. 16 (1) 81 Link

Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy 2018. 14 (10) 1693-1709 Link

Münch C, Dikic I Publisher Correction: Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (8) 990 Link

Münch C, Dikic I Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (2) 122-124 Link

Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife 2018. 7 Link

Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 2017. 543 (7644) 211-216 Link

Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell 2016. 167 (4) 985-1000.e21 Link

Münch C, Harper JW Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation. Nature 2016. 534 (7609) 710-3 Link

Ordureau A, Münch C, Harper JW Quantifying ubiquitin signaling. Mol Cell 2015. 58 (4) 660-76 Link

Suraweera A, Münch C, Hanssum A, Bertolotti A Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol Cell 2012. 48 (2) 242-53 Link

Münch C, Bertolotti A Propagation of the prion phenomenon: beyond the seeding principle. J Mol Biol 2012. 421 (4-5) 491-8 Link

Münch C, Bertolotti A Self-propagation and transmission of misfolded mutant SOD1: prion or prion-like phenomenon? Cell Cycle 2011. 10 (11) 1711 Link

Münch C, O'Brien J, Bertolotti A Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci U S A 2011. 108 (9) 3548-53 Link

Münch C, Bertolotti A Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants. J Mol Biol 2010. 399 (3) 512-25 Link

Our Funding

European Research Council
Emmy Noether-Programm der DFG
Bundesministerium für Bildung und Forschung
Else Kröner Fresenius Stiftung
LOEWE Exzellenzinitative des Landes Hessen
SFB1177 - Autophagy
LOEWE Zentrum für Zell- und Gentherapie Frankfurt
Cardio Pulmonary Institute Frankfurt
ENABLE Frankfurt
Proxidrugs
Aventis Foundation
Johanna Quandt Young Academy