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Welcome to the

Münch lab

We are a international, multidisciplinary team focusing on the molecular mechanisms of life. Applying a combination of systems biology, biochemistry and molecular biology, we examine how stress responses shape cellular behavior and pathology. Our team consists of biochemists, physicians, pharmacists, bioinformaticians and biologists. Based in the collaborative environment of Frankfurt we strive to discover the big picture of biology.

Selected Publications

Michaelis JB et al. "Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy" Nature Communications 2022

Koschade SE et al. "Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia" Leukemia 2022

Schäfer JA, Bozkurt S, Michaelis JB et al. "Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery" Molecular Cell 2022

Klann K, Münch C "PBLMM: Peptide-based linear mixed models for differential expression analysis of shotgun proteomics data" J Cell Biochem 2022

Kohli A, Sauerhering L, Fehling SK, Klann K, Geiger H, Becker S, Koch B, Baer PC, Strecker T, Münch C "Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells" Life Sci Alliance 2022

Bojkova D, Klann K, Koch B et al. "Proteomics of SARS-CoV-2-infected host cells reveals therapy targets" Nature 2020 583, 469–472

Klann K, Bojkova D et al. "Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication" Molecular Cell 2020. 80 (1) 164-174.e4

Klann K et al. "Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α" Molecular Cell 2020, 77(4), 913-925.e4

Klann K et al. "Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements" Analytical Chemistry 2020, 92, 12, 8041-8045

Münch C and Harper JW "Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation" Nature 2016, 534 (7609) 710-3

All Publications

Publications from PubMed: 68


Sánchez-Martín P, Kriegenburg F, Alves L, Adam J, Elsaesser J, Babic R, Mancilla H, Licheva M, Tascher G, Münch C, Eimer S, Kraft C ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy. J Cell Sci 2023. Link

Räuber S, Schroeter CB, Strippel C, Nelke C, Ruland T, Dik A, Golombeck KS, Regner-Nelke L, Paunovic M, Esser D, Münch C, Rosenow F, van Duijn M, Henes A, Ruck T, Amit I, Leypoldt F, Titulaer MJ, Wiendl H, Meuth SG, Meyer Zu Hörste G, Melzer N Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis. J Autoimmun 2023. 135 102985 Link

Michaelis JB, Bozkurt S, Schäfer JA, Münch C Monitoring Mitochondrial Protein Import Using Mitochondrial Targeting Sequence (MTS)-eGFP. Bio Protoc 2022. 12 (24) Link

Nasrullah U, Stanke K, Recknagel V, Bozkurt S, Wurzel P, Gauer S, Imre G, Münch C, Pfeilschifter J, Eberhardt W The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1. Cells 2023. 12 (1) Link

Key J, Gispert S, Koornneef L, Sleddens-Linkels E, Kohli A, Torres-Odio S, Koepf G, Amr S, Reichlmeir M, Harter PN, West AP, Münch C, Baarends WM, Auburger G CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2. Cells 2022. 12 (1) Link

Walther M, Vestweber PK, Kühn S, Rieger U, Schäfer J, Münch C, Vogel-Kindgen S, Planz V, Windbergs M Bioactive Insulin-Loaded Electrospun Wound Dressings for Localized Drug Delivery and Stimulation of Protein Expression Associated with Wound Healing. Mol Pharm 2023. 20 (1) 241-254 Link

Merline R, Rödig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, Kögel D, Münch C, Wygrecka M, Schaefer L A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1) - a novel modulator of mitochondrial autophagy. Am J Physiol Cell Physiol 2022. Link

Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C, Kern A FACS-mediated isolation of native autophagic vesicles. Autophagy 2022. 1-2 Link

Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, Münch C, Rieger B, Namgaladze D, Herrera MG, Fiesel FC, Springer W, Mendes M, Stepien J, Barkovits K, Marcus K, Sickmann A, Dittmar G, Busch KB, Riedel D, Brini M, et al. LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. EMBO J 2022. 41 (24) e112006 Link

Koschade SE, Klann K, Shaid S, Vick B, Stratmann JA, Thölken M, Meyer LM, Nguyen TD, Campe J, Moser LM, Hock S, Baker F, Meyer CT, Wempe F, Serve H, Ullrich E, Jeremias I, Münch C, Brandts CH Correction: Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. Leukemia 2022. 36 (12) 2950 Link

Koschade SE, Tascher G, Parmar BS, Brandts CH, Münch C SpinTip: A Simple, Robust, and Versatile Preanalytical Method for Microscale Suspension Cell Proteomics. J Proteome Res 2022. 21 (11) 2827-2835 Link

Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C, Kern A Lipid and protein content profiling of isolated native autophagic vesicles. EMBO Rep 2022. 23 (12) e53065 Link

Divé I, Klann K, Michaelis JB, Heinzen D, Steinbach JP, Münch C, Ronellenfitsch MW Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner. Cell Death Discov 2022. 8 (1) 409 Link

Michaelis JB, Brunstein ME, Bozkurt S, Alves L, Wegner M, Kaulich M, Pohl C, Münch C Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Nat Commun 2022. 13 (1) 5164 Link

Karantanou C, Minciacchi VR, Kumar R, Zanetti C, Bravo J, S Pereira R, Tascher G, Tertel T, Covarrubias-Pinto A, Bankov K, Pfeffermann LM, Bonig H, Divieti-Pajevic P, McEwan DG, Giebel B, Münch C, Dikic I, Krause DS Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression. Blood Adv 2022. Link

Koschade SE, Klann K, Shaid S, Vick B, Stratmann JA, Thölken M, Meyer LM, Nguyen TD, Campe J, Moser LM, Hock S, Baker F, Meyer CT, Wempe F, Serve H, Ullrich E, Jeremias I, Münch C, Brandts CH Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. Leukemia 2022. 36 (10) 2396-2407 Link

Sutandy FXR, Tharyan RG, Münch C The beginning of a new era: pioneering direct screens for RNA modulators. Signal Transduct Target Ther 2022. 7 (1) 246 Link

Delaunay S, Pascual G, Feng B, Klann K, Behm M, Hotz-Wagenblatt A, Richter K, Zaoui K, Herpel E, Münch C, Dietmann S, Hess J, Benitah SA, Frye M Mitochondrial RNA modifications shape metabolic plasticity in metastasis. Nature 2022. 607 (7919) 593-603 Link

Fischer T, Hartmann O, Reissland M, Prieto-Garcia C, Klann K, Pahor N, Schülein-Völk C, Baluapuri A, Polat B, Abazari A, Gerhard-Hartmann E, Kopp HG, Essmann F, Rosenfeldt M, Münch C, Flentje M, Diefenbacher ME PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. Cell Biosci 2022. 12 (1) 50 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Bozkurt S, Pahor N, Fuss C, Schirbel A, Schülein-Völk C, Buchberger A, Calzado Canale MA, Rosenfeldt M, Dikic I, Münch C, Diefenbacher ME USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K. Mol Oncol 2022. 16 (17) 3082-3106 Link

Klann K, Münch C Quantitative Translation Proteomics Using mePROD. Methods Mol Biol 2022. 2428 75-87 Link

Klann K, Münch C PBLMM: Peptide-based linear mixed models for differential expression analysis of shotgun proteomics data. J Cell Biochem 2022. 123 (3) 691-696 Link

Kohli A, Sauerhering L, Fehling SK, Klann K, Geiger H, Becker S, Koch B, Baer PC, Strecker T, Münch C Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells. Life Sci Alliance 2022. 5 (5) Link

Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF Mitochondria shed their outer membrane in response to infection-induced stress. Science 2022. 375 (6577) eabi4343 Link

Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery. Mol Cell 2022. 82 (2) 435-446.e7 Link

Prieto-Garcia C, Hartmann O, Reissland M, Fischer T, Maier CR, Rosenfeldt M, Schülein-Völk C, Klann K, Kalb R, Dikic I, Münch C, Diefenbacher ME Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. Cell Death Differ 2022. 29 (3) 568-584 Link

Gama-Brambila RA, Chen J, Dabiri Y, Tascher G, Němec V, Münch C, Song G, Knapp S, Cheng X A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins. JACS Au 2021. 1 (6) 777-785 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Correction: Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2021. 125 (7) 1030 Link

Gerstmeier J, Possmayer AL, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D, Linder B Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel) 2021. 13 (14) Link

Lorenz NI, Sittig ACM, Urban H, Luger AL, Engel AL, Münch C, Steinbach JP, Ronellenfitsch MW Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide. Sci Rep 2021. 11 (1) 14161 Link

Gama-Brambila RA, Chen J, Zhou J, Tascher G, Münch C, Cheng X A PROTAC targets splicing factor 3B1. Cell Chem Biol 2021. 28 (11) 1616-1627.e8 Link

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C, Dikic I SIK2 orchestrates actin-dependent host response upon infection. Proc Natl Acad Sci U S A 2021. 118 (19) Link

Klann K, Tascher G, Münch C Virus systems biology: Proteomics profiling of dynamic protein networks during infection. Adv Virus Res 2021. 109 1-29 Link

Geßner A, Koch B, Klann K, Fuhrmann DC, Farmand S, Schubert R, Münch C, Geiger H, Baer PC Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells. Int J Mol Sci 2021. 22 (6) Link

Schwich OD, Blümel N, Keller M, Wegener M, Setty ST, Brunstein ME, Poser I, Mozos IRL, Suess B, Münch C, McNicoll F, Zarnack K, Müller-McNicoll M SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Genome Biol 2021. 22 (1) 82 Link

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021. 17 (1) 1-382 Link

Klann K, Münch C [Not Available]. Biospektrum (Heidelb) 2021. 27 (1) 40-45 Link

Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy 2021. 17 (11) 3424-3443 Link

Güllülü Ö, Hehlgans S, Mayer BE, Gößner I, Petraki C, Hoffmann M, Dombrowsky MJ, Kunzmann P, Hamacher K, Strebhardt K, Fokas E, Rödel C, Münch C, Rödel F A Spatial and Functional Interaction of a Heterotetramer Survivin-DNA-PKcs Complex in DNA Damage Response. Cancer Res 2021. 81 (9) 2304-2317 Link

Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C BAG3 Proteomic Signature under Proteostasis Stress. Cells 2020. 9 (11) Link

Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Münch C, Wass MN, Michaelis M, Cinatl J Aprotinin Inhibits SARS-CoV-2 Replication. Cells 2020. 9 (11) Link

Klann K, Münch C Unbiased translation proteomics upon cell stress. Mol Cell Oncol 2020. 7 (4) 1763150 Link

Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol Cell 2020. 80 (1) 164-174.e4 Link

McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? Diagnostics (Basel) 2020. 10 (8) Link

Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, Sisignano M The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. Cells 2020. 9 (7) Link

Klann K, Münch C Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements. Anal Chem 2020. 92 (12) 8041-8045 Link

Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Nature 2020. 583 (7816) 469-472 Link

Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics 2020. 21 (3) 187-203 Link

Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer 2020. 122 (9) 1391-1398 Link

Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med 2020. 12 (4) e11101 Link

Klann K, Tascher G, Münch C Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α. Mol Cell 2020. 77 (4) 913-925.e4 Link

Pitzius S, Osterburg C, Gebel J, Tascher G, Schäfer B, Zhou H, Münch C, Dötsch V TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain. Cell Death Dis 2019. 10 (10) 686 Link

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int 2019. 95 (3) 540-562 Link

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood 2019. 133 (2) 168-179 Link

Münch C The different axes of the mammalian mitochondrial unfolded protein response. BMC Biol 2018. 16 (1) 81 Link

Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy 2018. 14 (10) 1693-1709 Link

Münch C, Dikic I Publisher Correction: Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (8) 990 Link

Münch C, Dikic I Hitchhiking on selective autophagy. Nat Cell Biol 2018. 20 (2) 122-124 Link

Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife 2018. 7 Link

Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 2017. 543 (7644) 211-216 Link

Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell 2016. 167 (4) 985-1000.e21 Link

Münch C, Harper JW Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation. Nature 2016. 534 (7609) 710-3 Link

Ordureau A, Münch C, Harper JW Quantifying ubiquitin signaling. Mol Cell 2015. 58 (4) 660-76 Link

Suraweera A, Münch C, Hanssum A, Bertolotti A Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol Cell 2012. 48 (2) 242-53 Link

Münch C, Bertolotti A Propagation of the prion phenomenon: beyond the seeding principle. J Mol Biol 2012. 421 (4-5) 491-8 Link

Münch C, Bertolotti A Self-propagation and transmission of misfolded mutant SOD1: prion or prion-like phenomenon? Cell Cycle 2011. 10 (11) 1711 Link

Münch C, O'Brien J, Bertolotti A Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci U S A 2011. 108 (9) 3548-53 Link

Münch C, Bertolotti A Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants. J Mol Biol 2010. 399 (3) 512-25 Link

Our Funding

European Research Council
Emmy Noether-Programm der DFG
Bundesministerium für Bildung und Forschung
Else Kröner Fresenius Stiftung
LOEWE Exzellenzinitative des Landes Hessen
SFB1177 - Autophagy
LOEWE Zentrum für Zell- und Gentherapie Frankfurt
Cardio Pulmonary Institute Frankfurt
ENABLE Frankfurt
Proxidrugs
Aventis Foundation
Johanna Quandt Young Academy
EMBO Young Investigator Programme
Fraunhofer Innovation Center
SFB1531