Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I.
Nature. 2020 Nov;587(7835):657-662. doi: 10.1038/s41586-020-2601-5. Epub 2020 Jul 29.
PMID: 32726803 Link
Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis.
Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunz K, Hoelper S, Zia-Chahabi S, Jabagi MJ, Emmerich J, Dray-Spira R, Kuhlee F, Hackmann K, Schroeck E, Wenzel P, Müller S, Filmann N, Fontenay M, Pajevic PD, Krause DS.Blood. 2019 Jul 18;134(3):227-238. doi: 10.1182/blood.2018874214. Epub 2019 Apr 19.PMID: 31003999 Free PMC article. Link
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy.
Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I.Elife. 2017 Jun 15;6:e25555. doi: 10.7554/eLife.25555.PMID: 28617241 Link
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C.Elife. 2017 Feb 14;6:e23063. doi: 10.7554/eLife.23063.PMID: 28195531 Link
Inhibition of MLL1 histone methyltransferase brings the developmental clock back to naïve pluripotency.
Muller S, Nayak A.Stem Cell Investig. 2016 Oct 20;3:58. doi: 10.21037/sci.2016.09.14. eCollection 2016.PMID: 27868040 Link
Publications from PubMed: 63
Zhang L, Wirth M, Patra U, Stroh J, Isaakidis K, Rieger L, Kossatz S, Milanovic M, Zang C, Demel U, Keiten-Schmitz J, Wagner K, Steiger K, Rad R, Bassermann F, Müller S, Keller U, Schick M
Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response.
EMBO Mol Med
2023.
15
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e16431
Link
Demel UM, Wirth M, Yousefian S, Zhang L, Isaakidis K, Dönig J, Böger M, Singh N, Köse H, Haas S, Müller S, Schick M, Keller U
Small-molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy.
Haematologica
2023.
108
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555-567
Link
Tahiri A, Puco K, Naji F, Kristensen VN, Alfsen GC, Farkas L, Nilsen FS, Müller S, Oldenburg J, Geisler J
Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors.
Oncotarget
2022.
13
970-981
Link
Heynen GJJE, Baumgartner F, Heider M, Patra U, Holz M, Braune J, Kaiser M, Schäffer I, Bamopoulos SA, Ramberger E, Murgai A, Ng YLD, Demel UM, Laue D, Liebig S, Krüger J, Janz M, Nogai A, Schick M, Mertins P, Müller S, Bassermann F, Krönke J, Keller U, Wirth M, et al.
SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma.
Blood Adv
2023.
7
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469-481
Link
Demel UM, Böger M, Yousefian S, Grunert C, Zhang L, Hotz PW, Gottschlich A, Köse H, Isaakidis K, Vonficht D, Grünschläger F, Rohleder E, Wagner K, Dönig J, Igl V, Brzezicha B, Baumgartner F, Habringer S, Löber J, Chapuy B, Weidinger C, Kobold S, Haas S, Busse AB, Müller S, et al.
Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
J Clin Invest
2022.
132
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Link
Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, et al.
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Nat Commun
2022.
13
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281
Link
Hotz PW, Müller S, Mendler L
SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease.
Front Mol Biosci
2021.
8
786136
Link
Patra U, Müller S
A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity.
Front Cell Dev Biol
2021.
9
696234
Link
Keiten-Schmitz J, Röder L, Hornstein E, Müller-McNicoll M, Müller S
SUMO: Glue or Solvent for Phase-Separated Ribonucleoprotein Complexes and Molecular Condensates?
Front Mol Biosci
2021.
8
673038
Link
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, et al.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
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17
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1-382
Link
Hotz PW, Wiesnet M, Tascher G, Braun T, Müller S, Mendler L
Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury.
Molecules
2020.
25
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Link
Keiten-Schmitz J, Wagner K, Piller T, Kaulich M, Alberti S, Müller S
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.
Mol Cell
2020.
79
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54-67.e7
Link
Biederstädt A, Hassan Z, Schneeweis C, Schick M, Schneider L, Muckenhuber A, Hong Y, Siegers G, Nilsson L, Wirth M, Dantes Z, Steiger K, Schunck K, Langston S, Lenhof HP, Coluccio A, Orben F, Slawska J, Scherger A, Saur D, Müller S, Rad R, Weichert W, Nilsson J, Reichert M, et al.
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
Gut
2020.
69
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1472-1482
Link
Keiten-Schmitz J, Schunck K, Müller S
SUMO Chains Rule on Chromatin Occupancy.
Front Cell Dev Biol
2019.
7
343
Link
Wagner K, Kunz K, Piller T, Tascher G, Hölper S, Stehmeier P, Keiten-Schmitz J, Schick M, Keller U, Müller S
The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics.
Cell Rep
2019.
29
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480-494.e5
Link
Kunz K, Müller S, Mendler L
Assays of SUMO protease/isopeptidase activity and function in mammalian cells and tissues.
Methods Enzymol
2019.
618
389-410
Link
Gärtner A, Wagner K, Hölper S, Kunz K, Rodriguez MS, Müller S
Acetylation of SUMO2 at lysine 11 favors the formation of non-canonical SUMO chains.
EMBO Rep
2018.
19
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Link
Kunz K, Piller T, Müller S
SUMO-specific proteases and isopeptidases of the SENP family at a glance.
J Cell Sci
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131
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Link
Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov VV, Rodriguez MS, Dötsch V, Müller S, Ernst A
Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.
J Biol Chem
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292
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15340-15351
Link
Nayak A, Reck A, Morsczeck C, Müller S
Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct genes.
Epigenetics Chromatin
2017.
10
15
Link
Raman N, Weir E, Müller S
The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling.
Mol Cell
2016.
64
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607-615
Link
Husnjak K, Keiten-Schmitz J, Müller S
Identification and Characterization of SUMO-SIM Interactions.
Methods Mol Biol
2016.
1475
79-98
Link
Kunz K, Wagner K, Mendler L, Hölper S, Dehne N, Müller S
SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases.
Cell Rep
2016.
16
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3075-3086
Link
Mendler L, Braun T, Müller S
The Ubiquitin-Like SUMO System and Heart Function: From Development to Disease.
Circ Res
2016.
118
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132-44
Link
Nayak A, Müller S
SUMO-specific proteases/isopeptidases: SENPs and beyond.
Genome Biol
2014.
15
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422
Link
Raman N, Nayak A, Muller S
mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3.
Mol Cell Biol
2014.
34
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4474-84
Link
Gärtner A, Muller S
PML, SUMO, and RNF4: guardians of nuclear protein quality.
Mol Cell
2014.
55
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1-3
Link
Nayak A, Viale-Bouroncle S, Morsczeck C, Muller S
The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.
Mol Cell
2014.
55
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47-58
Link
Raman N, Nayak A, Muller S
The SUMO system: a master organizer of nuclear protein assemblies.
Chromosoma
2013.
122
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475-85
Link
Ullmann R, Chien CD, Avantaggiati ML, Muller S
An acetylation switch regulates SUMO-dependent protein interaction networks.
Mol Cell
2012.
46
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759-70
Link
Finkbeiner E, Haindl M, Raman N, Muller S
SUMO routes ribosome maturation.
Nucleus
2011.
2
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527-32
Link
van Wijk SJ, Müller S, Dikic I
Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair.
Genes Dev
2011.
25
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1763-9
Link
Finkbeiner E, Haindl M, Muller S
The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.
EMBO J
2011.
30
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1067-78
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Jentsch S, Müller S
Regulatory Functions of Ubiquitin and SUMO in DNA Repair Pathways.
Subcell Biochem
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54
184-94
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Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.
FASEB J
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23
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3978-89
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Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y
E6AP promotes the degradation of the PML tumor suppressor.
Cell Death Differ
2009.
16
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1156-66
Link
Stehmeier P, Muller S
Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling.
Mol Cell
2009.
33
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400-9
Link
Stehmeier P, Muller S
Regulation of p53 family members by the ubiquitin-like SUMO system.
DNA Repair (Amst)
2009.
8
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491-8
Link
Klein UR, Haindl M, Nigg EA, Muller S
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.
Mol Biol Cell
2009.
20
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410-8
Link
Muller S, Dobner T
The adenovirus E1B-55K oncoprotein induces SUMO modification of p53.
Cell Cycle
2008.
7
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754-8
Link
Haindl M, Harasim T, Eick D, Muller S
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.
EMBO Rep
2008.
9
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273-9
Link
Buschbeck M, Uribesalgo I, Ledl A, Gutierrez A, Minucci S, Muller S, Di Croce L
PML4 induces differentiation by Myc destabilization.
Oncogene
2007.
26
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3415-22
Link
Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkrüger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Müller S, Solimena M
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5.
Nat Cell Biol
2006.
8
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435-45
Link
Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M
Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.
Mol Cell Biol
2005.
25
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6964-79
Link
Ledl A, Schmidt D, Müller S
Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor.
Oncogene
2005.
24
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3810-8
Link
Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch KP, Müller S, Solimena M
Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells.
J Cell Biol
2004.
167
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1063-74
Link
Müller S, Ledl A, Schmidt D
SUMO: a regulator of gene expression and genome integrity.
Oncogene
2004.
23
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1998-2008
Link
Schmidt D, Müller S
PIAS/SUMO: new partners in transcriptional regulation.
Cell Mol Life Sci
2003.
60
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2561-74
Link
García-Estrada C, Reguera RM, Villa H, Requena JM, Müller S, Pérez-Pertejo Y, Balaña-Fouce R, Ordóñez D
Identification of a gene in Leishmania infantum encoding a protein that contains a SP-RING/MIZ zinc finger domain.
Biochim Biophys Acta
2003.
1629
(1-3)
44-52
Link
Netzer C, Bohlander SK, Rieger L, Müller S, Kohlhase J
Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1.
Biochem Biophys Res Commun
2002.
296
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870-6
Link
Kirsh O, Seeler JS, Pichler A, Gast A, Müller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
EMBO J
2002.
21
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2682-91
Link
Schmidt D, Müller S
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.
Proc Natl Acad Sci U S A
2002.
99
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2872-7
Link
Müller S, Hoege C, Pyrowolakis G, Jentsch S
SUMO, ubiquitin's mysterious cousin.
Nat Rev Mol Cell Biol
2001.
2
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202-10
Link
Lehembre F, Müller S, Pandolfi PP, Dejean A
Regulation of Pax3 transcriptional activity by SUMO-1-modified PML.
Oncogene
2001.
20
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1-9
Link
Muller S, Berger M, Lehembre F, Seeler JS, Haupt Y, Dejean A
c-Jun and p53 activity is modulated by SUMO-1 modification.
J Biol Chem
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275
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13321-9
Link
Zhong S, Müller S, Ronchetti S, Freemont PS, Dejean A, Pandolfi PP
Role of SUMO-1-modified PML in nuclear body formation.
Blood
2000.
95
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2748-52
Link
Lehembre F, Badenhorst P, Müller S, Travers A, Schweisguth F, Dejean A
Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies.
Mol Cell Biol
2000.
20
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1072-82
Link
Müller S, Dejean A
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption.
J Virol
1999.
73
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5137-43
Link
Müller S, Miller WH, Dejean A
Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells.
Blood
1998.
92
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4308-16
Link
Müller S, Matunis MJ, Dejean A
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.
EMBO J
1998.
17
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61-70
Link
Dümmler K, Müller S, Seitz HJ
Regulation of adenine nucleotide translocase and glycerol 3-phosphate dehydrogenase expression by thyroid hormones in different rat tissues.
Biochem J
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317 ( Pt 3)
(Pt 3)
913-8
Link
Müller S, Seitz HJ
Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones.
Proc Natl Acad Sci U S A
1994.
91
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10581-5
Link
Watts RA, Winska-Wiloch H, Muller S, Isenberg DA
Analysis of factors affecting human hybridoma production.
Hum Antibodies Hybridomas
1990.
1
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160-5
Link
