Publications from PubMed: 75
Pecorilla C, Altmeyer A, Haapanen O, Lee Y, Zickermann V, Sharma V
Conformational dynamics of a histidine molecular switch in a cation/proton antiporter.
Biochim Biophys Acta Bioenerg
2025.
1866
(4)
149563
Link
Lasham J, Djurabekova A, Kolypetris G, Zickermann V, Vonck J, Sharma V
Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I.
Biochim Biophys Acta Bioenerg
2025.
1866
(1)
149512
Link
Méndez D, Tellería F, Monroy-Cárdenas M, Montecino-Garrido H, Mansilla S, Castro L, Trostchansky A, Muñoz-Córdova F, Zickermann V, Schiller J, Alfaro S, Caballero J, Araya-Maturana R, Fuentes E
Linking triphenylphosphonium cation to a bicyclic hydroquinone improves their antiplatelet effect via the regulation of mitochondrial function.
Redox Biol
2024.
72
103142
Link
Djurabekova A, Lasham J, Zdorevskyi O, Zickermann V, Sharma V
Long-range electron proton coupling in respiratory complex I - insights from molecular simulations of the quinone chamber and antiporter-like subunits.
Biochem J
2024.
481
(7)
499-514
Link
Lasham J, Djurabekova A, Zickermann V, Vonck J, Sharma V
Role of Protonation States in the Stability of Molecular Dynamics Simulations of High-Resolution Membrane Protein Structures.
J Phys Chem B
2024.
128
(10)
2304-2316
Link
Laube E, Schiller J, Zickermann V, Vonck J
Using cryo-EM to understand the assembly pathway of respiratory complex I.
Acta Crystallogr D Struct Biol
2024.
80
(Pt 3)
159-173
Link
Lasham J, Haapanen O, Zickermann V, Sharma V
Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I.
Biochim Biophys Acta Bioenerg
2023.
1864
(2)
148951
Link
Schiller J, Laube E, Wittig I, Kühlbrandt W, Vonck J, Zickermann V
Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling.
Sci Adv
2022.
8
(46)
eadd3855
Link
Lee Y, Haapanen O, Altmeyer A, Kühlbrandt W, Sharma V, Zickermann V
Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations.
Nat Commun
2022.
13
(1)
6091
Link
Schiller J, Zickermann V
Binding of Natural Inhibitors to Respiratory Complex I.
Pharmaceuticals (Basel)
2022.
15
(9)
Link
Djurabekova A, Galemou Yoga E, Nyman A, Pirttikoski A, Zickermann V, Haapanen O, Sharma V
Docking and molecular simulations reveal a quinone-binding site on the surface of respiratory complex I.
FEBS Lett
2022.
596
(9)
1133-1146
Link
Parey K, Lasham J, Mills DJ, Djurabekova A, Haapanen O, Yoga EG, Xie H, Kühlbrandt W, Sharma V, Vonck J, Zickermann V
High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism.
Sci Adv
2021.
7
(46)
eabj3221
Link
Kahlhöfer F, Gansen M, Zickermann V
Accessory Subunits of the Matrix Arm of Mitochondrial Complex I with a Focus on Subunit NDUFS4 and Its Role in Complex I Function and Assembly.
Life (Basel)
2021.
11
(5)
Link
Galemou Yoga E, Schiller J, Zickermann V
Ubiquinone Binding and Reduction by Complex I-Open Questions and Mechanistic Implications.
Front Chem
2021.
9
672851
Link
Galemou Yoga E, Parey K, Djurabekova A, Haapanen O, Siegmund K, Zwicker K, Sharma V, Zickermann V, Angerer H
Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I.
Nat Commun
2020.
11
(1)
6008
Link
Scherr J, Tang Z, Küllmer M, Balser S, Scholz AS, Winter A, Parey K, Rittner A, Grininger M, Zickermann V, Rhinow D, Terfort A, Turchanin A
Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy.
ACS Nano
2020.
14
(8)
9972-9978
Link
Parey K, Wirth C, Vonck J, Zickermann V
Respiratory complex I - structure, mechanism and evolution.
Curr Opin Struct Biol
2020.
63
1-9
Link
Galemou Yoga E, Angerer H, Parey K, Zickermann V
Respiratory complex I - Mechanistic insights and advances in structure determination.
Biochim Biophys Acta Bioenerg
2020.
1861
(3)
148153
Link
Parey K, Haapanen O, Sharma V, Köfeler H, Züllig T, Prinz S, Siegmund K, Wittig I, Mills DJ, Vonck J, Kühlbrandt W, Zickermann V
High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease.
Sci Adv
2019.
5
(12)
eaax9484
Link
Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V
Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.
Biochim Biophys Acta Bioenerg
2019.
1860
(7)
573-581
Link
Scherr J, Neuhaus A, Parey K, Klusch N, Murphy BJ, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D
Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy.
ACS Nano
2019.
13
(6)
7185-7190
Link
Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U
Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.
Nat Commun
2018.
9
(1)
4500
Link
Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kühlbrandt W, Zickermann V
Cryo-EM structure of respiratory complex I at work.
Elife
2018.
7
Link
Angerer H, Schönborn S, Gorka J, Bahr U, Karas M, Wittig I, Heidler J, Hoffmann J, Morgner N, Zickermann V
Acyl modification and binding of mitochondrial ACP to multiprotein complexes.
Biochim Biophys Acta Mol Cell Res
2017.
1864
(10)
1913-1920
Link
Scherr J, Parey K, Klusch N, Murphy BJ, Balser S, Neuhaus A, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D
Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy.
ACS Nano
2017.
11
(6)
6467-6473
Link
Krishnathas R, Bonke E, Dröse S, Zickermann V, Nasiri HR
Identification of 4--[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I.
Medchemcomm
2017.
8
(3)
657-661
Link
Kahlhöfer F, Kmita K, Wittig I, Zwicker K, Zickermann V
Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I.
Biochim Biophys Acta Bioenerg
2017.
1858
(2)
175-181
Link
D'Imprima E, Mills DJ, Parey K, Brandt U, Kühlbrandt W, Zickermann V, Vonck J
Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism.
Biochim Biophys Acta
2016.
1857
(12)
1935-1942
Link
Hahn A, Parey K, Bublitz M, Mills DJ, Zickermann V, Vonck J, Kühlbrandt W, Meier T
Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology.
Mol Cell
2016.
63
(3)
445-56
Link
Brandt UU, Zickermann V
Preface to complex I special issue.
Biochim Biophys Acta
2016.
1857
(7)
861-2
Link
Wirth C, Brandt U, Hunte C, Zickermann V
Structure and function of mitochondrial complex I.
Biochim Biophys Acta
2016.
1857
(7)
902-14
Link
Kmita K, Wirth C, Warnau J, Guerrero-Castillo S, Hunte C, Hummer G, Kaila VR, Zwicker K, Brandt U, Zickermann V
Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.
Proc Natl Acad Sci U S A
2015.
112
(18)
5685-90
Link
Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U
Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I.
Science
2015.
347
(6217)
44-9
Link
Angerer H, Radermacher M, Mańkowska M, Steger M, Zwicker K, Heide H, Wittig I, Brandt U, Zickermann V
The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity.
Proc Natl Acad Sci U S A
2014.
111
(14)
5207-12
Link
Kmita K, Zickermann V
Accessory subunits of mitochondrial complex I.
Biochem Soc Trans
2013.
41
(5)
1272-9
Link
Radermacher M, Ruiz T, Fowler DJ, Yu L, Dröse S, Krack S, Kerscher S, Zickermann V, Brandt U
3D Reconstruction of a Subcomplex of NADH-ubiquinone-oxidoreductase (Complex I) from Yarrowia lipolytica.
Microsc Microanal
2011.
17
(S2)
90-91
Link
Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.
EMBO J
2012.
31
(2)
443-56
Link
Dröse S, Krack S, Sokolova L, Zwicker K, Barth HD, Morgner N, Heide H, Steger M, Nübel E, Zickermann V, Kerscher S, Brutschy B, Radermacher M, Brandt U
Functional dissection of the proton pumping modules of mitochondrial complex I.
PLoS Biol
2011.
9
(8)
e1001128
Link
Davies KM, Strauss M, Daum B, Kief JH, Osiewacz HD, Rycovska A, Zickermann V, Kühlbrandt W
Macromolecular organization of ATP synthase and complex I in whole mitochondria.
Proc Natl Acad Sci U S A
2011.
108
(34)
14121-6
Link
Angerer H, Zwicker K, Wumaier Z, Sokolova L, Heide H, Steger M, Kaiser S, Nübel E, Brutschy B, Radermacher M, Brandt U, Zickermann V
A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I.
Biochem J
2011.
437
(2)
279-88
Link
Ladig R, Sommer MS, Hahn A, Leisegang MS, Papasotiriou DG, Ibrahim M, Elkehal R, Karas M, Zickermann V, Gutensohn M, Brandt U, Klösgen RB, Schleiff E
A high-definition native polyacrylamide gel electrophoresis system for the analysis of membrane complexes.
Plant J
2011.
67
(1)
181-94
Link
Hunte C, Zickermann V, Brandt U
Functional modules and structural basis of conformational coupling in mitochondrial complex I.
Science
2010.
329
(5990)
448-51
Link
Tocilescu MA, Zickermann V, Zwicker K, Brandt U
Quinone binding and reduction by respiratory complex I.
Biochim Biophys Acta
2010.
1797
(12)
1883-90
Link
Zickermann V, Angerer H, Ding MG, Nübel E, Brandt U
Small single transmembrane domain (STMD) proteins organize the hydrophobic subunits of large membrane protein complexes.
FEBS Lett
2010.
584
(12)
2516-25
Link
Zickermann V, Wumaier Z, Wrzesniewska B, Hunte C, Schägger H
Native immunoblotting of blue native gels to identify conformation-specific antibodies.
Proteomics
2010.
10
(1)
159-63
Link
Clason T, Ruiz T, Schägger H, Peng G, Zickermann V, Brandt U, Michel H, Radermacher M
The structure of eukaryotic and prokaryotic complex I.
J Struct Biol
2010.
169
(1)
81-8
Link
Zickermann V, Kerscher S, Zwicker K, Tocilescu MA, Radermacher M, Brandt U
Architecture of complex I and its implications for electron transfer and proton pumping.
Biochim Biophys Acta
2009.
1787
(6)
574-83
Link
Zickermann V, Dröse S, Tocilescu MA, Zwicker K, Kerscher S, Brandt U
Challenges in elucidating structure and mechanism of proton pumping NADH:ubiquinone oxidoreductase (complex I).
J Bioenerg Biomembr
2008.
40
(5)
475-83
Link
Morgner N, Zickermann V, Kerscher S, Wittig I, Abdrakhmanova A, Barth HD, Brutschy B, Brandt U
Subunit mass fingerprinting of mitochondrial complex I.
Biochim Biophys Acta
2008.
1777
(10)
1384-91
Link
Clason T, Zickermann V, Ruiz T, Brandt U, Radermacher M
Direct localization of the 51 and 24 kDa subunits of mitochondrial complex I by three-dimensional difference imaging.
J Struct Biol
2007.
159
(3)
433-42
Link
Kerscher S, Dröse S, Zickermann V, Brandt U
The three families of respiratory NADH dehydrogenases.
Results Probl Cell Differ
2008.
45
185-222
Link
Zickermann V, Zwicker K, Tocilescu MA, Kerscher S, Brandt U
Characterization of a subcomplex of mitochondrial NADH:ubiquinone oxidoreductase (complex I) lacking the flavoprotein part of the N-module.
Biochim Biophys Acta
2007.
1767
(5)
393-400
Link
Abdrakhmanova A, Zwicker K, Kerscher S, Zickermann V, Brandt U
Tight binding of NADPH to the 39-kDa subunit of complex I is not required for catalytic activity but stabilizes the multiprotein complex.
Biochim Biophys Acta
2006.
1757
(12)
1676-82
Link
Marshall D, Fisher N, Grigic L, Zickermann V, Brandt U, Shannon RJ, Hirst J, Lawrence R, Rich PR
ATR-FTIR redox difference spectroscopy of Yarrowia lipolytica and bovine complex I.
Biochemistry
2006.
45
(17)
5458-67
Link
Radermacher M, Ruiz T, Clason T, Benjamin S, Brandt U, Zickermann V
The three-dimensional structure of complex I from Yarrowia lipolytica: a highly dynamic enzyme.
J Struct Biol
2006.
154
(3)
269-79
Link
Maly T, Grgic L, Zwicker K, Zickermann V, Brandt U, Prisner T
Cluster N1 of complex I from Yarrowia lipolytica studied by pulsed EPR spectroscopy.
J Biol Inorg Chem
2006.
11
(3)
343-50
Link
Brandt U, Abdrakhmanova A, Zickermann V, Galkin A, Dröse S, Zwicker K, Kerscher S
Structure-function relationships in mitochondrial complex I of the strictly aerobic yeast Yarrowia lipolytica.
Biochem Soc Trans
2005.
33
(Pt 4)
840-4
Link
Waletko A, Zwicker K, Abdrakhmanova A, Zickermann V, Brandt U, Kerscher S
Histidine 129 in the 75-kDa subunit of mitochondrial complex I from Yarrowia lipolytica is not a ligand for [Fe4S4] cluster N5 but is required for catalytic activity.
J Biol Chem
2005.
280
(7)
5622-5
Link
Abdrakhmanova A, Zickermann V, Bostina M, Radermacher M, Schägger H, Kerscher S, Brandt U
Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica.
Biochim Biophys Acta
2004.
1658
(1-2)
148-56
Link
Brandt U, Kerscher S, Dröse S, Zwicker K, Zickermann V
Proton pumping by NADH:ubiquinone oxidoreductase. A redox driven conformational change mechanism?
FEBS Lett
2003.
545
(1)
9-17
Link
Zickermann V, Bostina M, Hunte C, Ruiz T, Radermacher M, Brandt U
Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase.
J Biol Chem
2003.
278
(31)
29072-8
Link
Peng G, Fritzsch G, Zickermann V, Schägger H, Mentele R, Lottspeich F, Bostina M, Radermacher M, Huber R, Stetter KO, Michel H
Isolation, characterization and electron microscopic single particle analysis of the NADH:ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus.
Biochemistry
2003.
42
(10)
3032-9
Link
Kerscher S, Dröse S, Zwicker K, Zickermann V, Brandt U
Yarrowia lipolytica, a yeast genetic system to study mitochondrial complex I.
Biochim Biophys Acta
2002.
1555
(1-3)
83-91
Link
Kerscher S, Kashani-Poor N, Zwicker K, Zickermann V, Brandt U
Exploring the catalytic core of complex I by Yarrowia lipolytica yeast genetics.
J Bioenerg Biomembr
2001.
33
(3)
187-96
Link
Kashani-Poor N, Kerscher S, Zickermann V, Brandt U
Efficient large scale purification of his-tagged proton translocating NADH:ubiquinone oxidoreductase (complex I) from the strictly aerobic yeast Yarrowia lipolytica.
Biochim Biophys Acta
2001.
1504
(2-3)
363-70
Link
Kurki S, Zickermann V, Kervinen M, Hassinen I, Finel M
Mutagenesis of three conserved Glu residues in a bacterial homologue of the ND1 subunit of complex I affects ubiquinone reduction kinetics but not inhibition by dicyclohexylcarbodiimide.
Biochemistry
2000.
39
(44)
13496-502
Link
Okun JG, Zickermann V, Zwicker K, Schägger H, Brandt U
Binding of detergents and inhibitors to bovine complex I - a novel purification procedure for bovine complex I retaining full inhibitor sensitivity.
Biochim Biophys Acta
2000.
1459
(1)
77-87
Link
Zickermann V, Kurki S, Kervinen M, Hassinen I, Finel M
The NADH oxidation domain of complex I: do bacterial and mitochondrial enzymes catalyze ferricyanide reduction similarly?
Biochim Biophys Acta
2000.
1459
(1)
61-8
Link
Okun JG, Zickermann V, Brandt U
Properties of the common inhibitor-binding domain in mitochondrial NADH-dehydrogenase (complex I).
Biochem Soc Trans
1999.
27
(4)
596-601
Link
Björklöf K, Zickermann V, Finel M
Purification of the 45 kDa, membrane bound NADH dehydrogenase of Escherichia coli (NDH-2) and analysis of its interaction with ubiquinone analogues.
FEBS Lett
2000.
467
(1)
105-10
Link
Malatesta F, Nicoletti F, Zickermann V, Ludwig B, Brunori M
Electron entry in a CuA mutant of cytochrome c oxidase from Paracoccus denitrificans. Conclusive evidence on the initial electron entry metal center.
FEBS Lett
1998.
434
(3)
322-4
Link
Zickermann V, Barquera B, Wikström M, Finel M
Analysis of the pathogenic human mitochondrial mutation ND1/3460, and mutations of strictly conserved residues in its vicinity, using the bacterium Paracoccus denitrificans.
Biochemistry
1998.
37
(34)
11792-6
Link
Zickermann V, Wittershagen A, Kolbesen BO, Ludwig B
Transformation of the CuA redox site in cytochrome c oxidase into a mononuclear copper center.
Biochemistry
1997.
36
(11)
3232-6
Link
Zickermann V, Verkhovsky M, Morgan J, Wikström M, Anemüller S, Bill E, Steffens GC, Ludwig B
Perturbation of the CuA site in cytochrome-c oxidase of Paracoccus denitrificans by replacement of Met227 with isoleucine.
Eur J Biochem
1995.
234
(2)
686-93
Link
Witt H, Zickermann V, Ludwig B
Site-directed mutagenesis of cytochrome c oxidase reveals two acidic residues involved in the binding of cytochrome c.
Biochim Biophys Acta
1995.
1230
(1-2)
74-6
Link
High-resolution cryo-EM structure of complex I from Yarrowia lipolytica
