ER Quality Control

Alexandra Stolz studied Biochemistry in Regensburg, Germany followed by a PhD in yeast genetics and molecular biology in Stuttgart, Germany. After a postdoc (2012-2013) working on ER associated protein degradation (ERAD) – a proteasome dependent pathway, Alexandra joined the groups of Andreas Ernst and Ivan Dikic at IBC2 in Frankfurt, Germany (2013-2016) to work on autophagy. Besides contributing to the characterization of the first autophagy receptor for ER-phagy FAM134B and elaborating the role of the kinase TBK1 in mitophagy, she utilized phage display and protein engineering to develop fluorescent sensors for the central autophagy components LC3/GABARAPs. In January 2017, she joined Genentech in South San Francisco, USA as a visiting scientist where she studied the impact of oncogene-induced secretion during cancer pathogenesis. Since February 2018, Alexandra is heading the phenotypic screening platform at IBC2  and since January 2021 as well the ER quality control group located at the Buchman Institute for Molecular Life Sciences (BMLS) as an indipendent group leader. Alexandra is  associated with EUbOPEN, where her group aims to identify chemical inducers and inhibitors of selective autophagy pathways. 

Hung obtained his Bachelor's degree in Biochemistry in 2009 from the Talented Program of Hanoi University of Science, Vietnam.  After that, he joined Vu Tan Trao lab as a research assistant at the National Institute of Hygiene and Epidemiology in Hanoi, Vietnam. With support from the Swiss Federal Fellowship, he completed his Master's degree in Biochemistry from the Department of Biology in Ari Helenius' lab at ETH Zürich, Switzerland. In 2013, he visited the Michael Veit lab at Free University in Berlin, Germany as a research assistant to work on the mechanism of virus egression from the cells.  Starting 2014, he received the Marie Skłodowska-Curie Fellowship ‘’RNAtrain’’ to pursue his PhD in RNA Biochemistry at Gunter Meister lab at the University of Regensburg, Germany. After finishing his PhD thesis in 2018, he stayed in the lab as a postdoctoral fellow. During his time in Regensburg, he focused on analyzing the coding potential of non-coding RNAs, including circRNAs and lncRNAs, and the utilizing these microproteins’ functions in different cellular contexts. In June 2021, he joined the Stolz lab to study different aspects of autophagy regulation, especially ER-phagy during cellular homeostasis. 

Katharina studied Biological Sciences at the Universität Konstanz (Germany) and obtained a Bachelor’s Degree in 2015 and a Master’s Degree in 2018. Having received a stipend from the MRC (Medical Research Council (UK)), she then moved on to the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee (UK) for her PhD with Prof Dr Ian Ganley. Her PhD focused on elucidating the mechanisms of mitophagy (the degradation of mitochondria via autophagy) and targeted organelle degradation. After a short-term post-doc position in the Ganley lab following her PhD, Katharina joined the Stolz lab in 2024 as a post-doctoral researcher to work on ER-phagy and the role and regulation of different receptors in this process.

Lautaro Natali holds a Biology degree from Universidad Nacional de Córdoba (Argentina), where he graduated with honors in 2020. He conducted his bachelor's thesis at the Laboratory of Epigenetics and Cell Differentiation in the Mercedes and Martin Ferreyra Institute for Medical Research in Córdoba (Argentina), focusing on the role of the transcription factor SLUG in miRNA modulation during smooth muscle cell phenotypic switch. He subsequently obtained a PhD scholarship from the Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET) in 2020 to explore the role of RNA methylation in smooth muscle cell differentiation under the supervision of Dr. Melina Musri. Supported by the SFB1177, Lautaro is currently doing a research stay at the Stolz lab, where he is studying the role of autophagy in this process. 

Lorène obtained her Master degree in Neuroscience in 2017 from the university of Montpellier (France). After receiving a Labex EpigenMed PhD scholarships, she joined Dimitris Xirodimas’ lab in Montpellier. Her PhD focused on the characterization of the nuclear protein quality control in mammals and understanding how the nucleus can eliminate nuclear protein aggregates. Lorène joined the Stolz lab in April 2022 as a post-doctoral researcher in order to broaden her expertise in quality control and investigate processes of selective autophagy in mammals.

Pablo obtained his bachelor’s degree in biotechnology on 2018 at the university of Francisco de Vitoria in Madrid (Spain). He joined Prof. Ivan Dikic’s lab to carry out his bachelor thesis on general autophagy probes and receptors. After obtaining his degree, he enrolled in the Master in Neuroscience of Universidad Autonoma de Madrid (Spain). He started his master thesis in 2019 at the laboratory of Dr. Manuel Valiente at Centro Nacional de Investigaciones Oncologicas (CNIO). He studied the latency experienced by brain metastasis initiating cells. After obtaining his master degree, he wished to dive deeper into molecular signaling and trafficking which led him to enroll, in 2021, in a PhD at the Stolz lab where he will focus on the study of ER quality control and its implications in cell biology.

Palak completed her bachelor's in life sciences at the Sophia College for Women in Mumbai, India, working on the production of biodegradable bioplastic. In 2021 Palak moved to Germany for  pursuing a Master in Physical Biology of Cells and Cell Interactions at the Goethe University Frankfurt. After an internship in the Stolz lab, Palak stayed for completing her master thesis, working in collaboration with Hung Ho-Xuan to further characterize players of a selective autophagy pathway. 

Sara was studying Biotechnology at the University Francisco de Vitoria, Spain and joined the Stolz lab in September 2020 for her Bachelor thesis on the impact of kinase signaling comparing 2D vs. 3D cultured cells. After finishing her Bachelor, Sara stayed in the lab as a research assistant and Lab Manager with a focus on cellular screens.

Sevi completed her Bachelor's and Master's degrees in Biochemistry at Goethe University Frankfurt, Germany. Her Bachelor's thesis, under the supervision of Prof. Dr. Zoltán Ivics, was conducted at the Paul-Ehrlich-Institute, where she applied CRISPR-Cas technology to introduce mutations in the snRNP70 gene in human cells. She completed her Master's thesis under Prof. Dr. Robert Tampé at Goethe University, where she investigated T-cell receptor clustering and T-cell activation on microstructured matrices.

Adrian obtained his master’s degree in Molecular Biology and Neurobiology at TU Kaiserslautern In 2019, working on the impact of impaired mitochondrial protein import in D. melanogaster. Joining the Stolz Lab in 2020 as a PhD student, Adrian shifted his research interest towards the ER as part of a collaboration with the Lemberg lab at Universität zu Köln. There, he is investigating the impact of rhomboid pseudoproteases on membrane protein degradation in S. cerevisiae. Within the project, Adrian subsequently joined the Lemberg lab, to complete his project and PhD at the Universtät zu Köln.

Hassan studied physiology and genetics at National University Ireland Galway (NUIG), graduating with a BSC in Biomedical Science. He later completed his Masters in Biomedical Science with a focus on microbiology and infectious disease at Kingston Unversity London in 2016. His thesis investigated the isolation and determination of anti-microbial sensitivity of presumptive Campylobacter spp. with investigation of biofilm formation and microbial susceptibility to natural products, olive leaf extract and catechin hydrate.
Hassan then worked as a medical lab technician with the specialist children’s care hospital , Great Ormond Street Hospital (2015-2020) in different roles before moving to Frankfurt in 2020. He was part of the Stolz lab as a research assistant where he focused on aiding the PROXIDRUG team (www.proxidrugs.de).

After studying Biology at the Belgrad University, Serbia, Katarina finished her bachelor degree in molecular biology and subsequent master degree in biomedicine at the Johannes Gutenberg University Mainz, Germany. In 2018 Katarina joined the group for 7 months on a qualification scholarship working on the establishment cell based autophagy assays before moving on to an industrial position.

Miles completed his bachelor's degree in biochemistry at the Goethe-University of Frankfurt, Germany, under the supervision of Prof. Pos, working on heavy metal transport systems in bacteria. Due to an increasing interest in cellular biology and autophagy regulation, he joined the Stolz lab where he is investigating the regulation of ER membrane contact sites under ER stress for his master thesis. After leaving the Stolz lab, Miles started a PhD in the lab of Ivan Dikic. 

Pablo joined the Dikic group in 2018 during his last year of his biotechnology degree at Universidad Francisco de Vitoria (Madrid), to develop his bachelor thesis and lab experience. He was co-mentored by Alexandra snd stayed for 7 months working on the establishment of cell-based autophagy assays as well as the characterization of different interactors of autophagy receptors. Pablo later enrolled in the Master of Neuroscience of the Autonoma University of Madrid and made his Master thesis at the Spanish National Cancer Research Center (CNIO).

Paloma obtained both a Biotechnology degree and a diploma of Expert in Methodology & Experimental Innovation during her time at the University of Francisco de Vitoria, Spain. At this time she was also a laboratory assistant under the supervision of Prof. Lourdes Rufa working in the field of Pharmacology and Pharmacognosy. For her Bachelor thesis, Paloma joined the laboratory of Prof. Vicente Rubio and Dr. Pablo Pulido at the National Center for Biotechnology (CNB-CSIC), Spain, where she worked in the area of plant molecular genetics. In September 2022 Paloma joined the Stolz group as a reseache assistant.

Rayene is originally from Constantine, Algeria. She obtained her first Mater’s degree in human genetics with honor from the University Constantine. In Sep. 2017, she moved to France where she obtained a second Masters in Cancer Biology from Montpellier University. In Feb. 2020, Rayene moved to Frankfurt and joined the Stolz group as a Master’s intern. In her project, she focused mainly on the establishment of drug screening assays in lung cancer cell lines cultured in 2D and 3D, respectively. After completing her Master’s thesis, Rayene intended to explore another horizon and proceeded as a PhD student, shifting her focus towards deciphering the molecular mechanism of ER quality control check mechanism around the FAM134 family.

Sandra joined the lab in 2020 for her bachelor thesis, focusing on the impact of selected small molecules on general autophagy and ER-phagy flux, respectively. 

Tristan studies Bioscienes – Applied Biology for Medicine and Pharmacy at the Fresenius University of Applied Sciences. In his 5th semester he joined the Stolz lab for 6 months of wet-lab training. During his stay he is working with Rayene Berkane on the post-translational cues regulating the activity of FAM134 proteins. After working in the lab as as HiWi, Tristan started his Bachelor Thesis in February 2023.