Sebastian completed a Bachelor’s degree in Biosciences and a Master’s degree in Molecular Medicine at Goethe University, including a one-year research stay at UCLA in Los Angeles as part of the Master’s program. During his Master’s thesis, he gained initial experience with CRISPR screening, which motivated him to pursue a PhD in this field. Sebastian joined the Kaulich lab at the end of 2022, where he is establishing combinatorial CRISPR screens at a genome-wide scale to uncover novel genetic dependencies and mechanisms of cellular gene regulation. His current research centers on understanding how cells orchestrate transcriptional responses to gene perturbations in order to achieve genetic robustness.