Dr. Sergio Alejandro Poveda Cuevas
Alejandro received his bachelor's degree in biology from the Pedagogical and Technological University of Colombia. He continued his academic journey by earning a Master's in Bioinformatics from the University of São Paulo (USP), where he conducted research on cancer-related protein complexes and the refinement of force-field models for coarse-grained systems. He later pursued doctoral studies at USP, focusing his thesis on investigating the NS1 protein of the Zika virus. His research, utilizing molecular simulations, explored critical aspects such as protein oligomerization, membrane binding affinity, epitope estimation, and glycosylation, providing invaluable insights into molecular mechanisms and virulence of Zika virus. Currently, Alejandro is a post-doctoral researcher at the Computational Cell Biology lab, where he studies the biophysical properties of proteins involved in autophagy, with a particular emphasis on selective autophagy receptors. His primary research focuses on understanding the intrinsically disordered region (IDR) of the ER-phagy receptor FAM134B and its role in large-scale membrane remodeling events. His work revealed how the context-dependent, or "Janus-like" ensemble properties of the IDR actively influence membrane properties to both induce and sense positive membrane curvature, as well as facilitate the clustering and sorting of proteins during spontaneous budding processes.