Together with the Cluster of Excellence Macromolecular Complexes, the SFB 1177, and the DKTK Frankfurt, LOEWE Ub-Net is organizing the first Frankfurt Conference on Ubiquitin and Autophagy in July 2016. Both the ubiquitin system and autophagy are essential for maintaining cellular integrity and homeostasis. Defects in the two quality control systems are involved in the pathogenesis of numerous diseases. The conference brings together leading experts in this field.