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Following the unexpected announcement of Novo Nordisk Foundation (NNF) to stop core funding for its Center for Protein Research (CPR) in Copenhagen after 2024, former members of CPR’s Scientific Advisory Board have published an article in EMBO reports to highlight the hidden risks of jointly funded, “mission-driven” projects. The authors – amongst them IBC2 director Ivan Đikić – highlight the importance of protecting funding for basic research to enable pioneering discoveries. They propose to establish standards for funding bodies to ensure transparency and consistency. Ultimately, the goal is to foster a vibrant basic research community for the benefit of society and future generations.

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International research teams from Goethe University Frankfurt and Jena University Hospital find mechanisms involved in regulation of structure and function of endoplasmic reticulum and elucidate a development of hereditary neurodegenerative diseases

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Alexandra Stolz, group leader at the Institute of Biochemistry II of Goethe University Frankfurt, received one of the prestigious Exploration Grants from the Boehringer Ingelheim Foundation. Her project aims to identify small molecules with impact on selective autophagy pathways that can be subsequently developed into potential drugs for the treatment of neurodegenerative diseases. 

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Lysosomes are small membranous organelles which are essential for recycling cellular waste. They are critical to cellular health and lysosomal dysfunction is a predominant feature of several diseases like lysosomal storage disorders, neurodegeneration and nephropathies. The absence of functional lysosomes leads to a build-up of toxic cellular waste which is detrimental to all aspects of cellular metabolism and function. 

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Ivan Đikić, IBC2 Director and Brenda Schulman, Director at the Max Planck Institute of Biochemistry in Martinsried will together be awarded the 2023 Louis-Jeantet Prize for medicine for their outstanding scientific achievements in the ubiquitin field.

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