Conferences and Workshops

3rd Frankfurt Conference on Quality Control in Life Processes

The 3rd Frankfurt Conference on Quality Control in Life Processes,
organized by SFB1177 and ENABLE, is taking place October 3-7,2022 at Goethe University Frankfurt.  
The meeting brings scientists on all career stages together to discuss mechanisms of cellular homeostasis
and their impact on pathogenesis of major human diseases.
This year’s Conference features interdisciplinary sessions that cover topics
including immunity and quality control, regulatory events and the interplay between autophagy, ubiquitin and proteostasis.

More information can be found here: www.FCQC.de
 

The research in our group is focused on the development and application of nuclear magnetic resonance (NMR) spectroscopy to study biomacromolecules. Our focus is to contribute to a molecular understanding of the fundamental mechanism of biomacromolecules. We investigate proteins - soluble proteins and membrane proteins. We investigate RNAs and RNA-protein complexes and unusual DNA structures.

Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophores. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kinds of experiments.

We also investigate proteins structures to contribute to rational drug discovery and support our mechanistic studies by chemical synthesis.