Conferences and Workshops
Institute for Organic Chemistry and Chemical Biology
Center for Biomolecular Magnetic Resonance (BMRZ)
Johann Wolfgang Goethe-University Frankfurt
27. Oct 2021 16:00h
Location: UKF, Hörsal 23-3, Haus 23
UKF, Hörsal 23-3, Haus 23
The research in our group is focused on the development and application of nuclear magnetic resonance (NMR) spectroscopy to study biomacromolecules. Our focus is to contribute to a molecular understanding of the fundamental mechanism of biomacromolecules. We investigate proteins - soluble proteins and membrane proteins. We investigate RNAs and RNA-protein complexes and unusual DNA structures.
Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophores. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kinds of experiments.
We also investigate proteins structures to contribute to rational drug discovery and support our mechanistic studies by chemical synthesis.
28. May 2021
we would like to invite you to the virtual workshop on “Mapping the Landscape of Genetic Dependencies in Cancer” to be held on May 28th, 2021.
Knowing the landscape of genetic vulnerabilities across cancer types is important for a deeper understanding of cancer biology, the discovery of new targets for drug development, overcoming treatment resistance and tailoring therapies to specific mutational contexts for precision medicine. The development of comprehensive and tumor-specific maps of genetic dependencies will require international efforts and coordination, not unlike international cancer genome sequencing projects in the past decade. Our workshop “Mapping the Landscape of Genetic Dependencies in Cancer” aims to discuss state-of the art technological, experimental, and computational advances for the large-scale discovery of genetic dependencies in cancer.
We have an exceptional line-up of speakers with Matthew Garnett (Sanger Institute), Jesse Boehm (Broad Institute) and Francisca Vazquez (Broad Institute), Jolanda van Leeuwen (EPFL) and Max Billmann (Univ. of Minnesota) and several early career scientists who will present on recent developments to map genetic dependencies at scale, including advances in genome-editing technologies, the creation of new cancer models and high-throughput functional genomics. The Workshop also will provide ample time for discussions with the invited speakers and among the participants.
The Workshop will be held online via Zoom and is free of charge. To participate, please register at: https://zoom.us/webinar/register/WN_OYWhATxxS8ihFoIXiiVWFw
We very much appreciate it if you could forward the attached announcement to interested colleagues. We very much look forward to welcoming you on May 28th.
Michael Boutros (Heidelberg), Manuel Kaulich (Frankfurt), Roland Rad (Munich)