Ubiquitin Signaling Group
Head: Dr. Koraljka Husnjak
Dynamic and reversible post-translational modifications by multifunctional protein ubiquitin regulate a variety of cellular processes including protein stability, DNA transcription and repair, endocytosis, cell cycle and division, apoptosis, autophagy, antigen processing, inflammation and immune response (1, 2). Research in Husnjak group is centred on the role of ubiquitin and ubiquitin-like proteins in protein degradation and regulation of proliferation, apoptosis and necroptosis. The group is especially interested in identifying novel players in linear ubiquitination, a type of atypical ubiquitination so far implicated in acquired and innate immunity, autoinflammation, lymphocyte development, genotoxic stress response and Parkinson´s disease, by utilizing multidisciplinary approaches ranging from biochemistry, molecular biology, cell culture, mass spectrometry, mouse models and collaboration-based structural studies.